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271 related items for PubMed ID: 2231606

  • 1. Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.
    Hughes LR, Jackman AL, Oldfield J, Smith RC, Burrows KD, Marsham PR, Bishop JA, Jones TR, O'Connor BM, Calvert AH.
    J Med Chem; 1990 Nov; 33(11):3060-7. PubMed ID: 2231606
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  • 6. Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents.
    Warner P, Barker AJ, Jackman AL, Burrows KD, Roberts N, Bishop JA, O'Connor BM, Hughes LR.
    J Med Chem; 1992 Jul 24; 35(15):2761-8. PubMed ID: 1495009
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  • 7. Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues.
    Thornton TJ, Jones TR, Jackman AL, Flinn A, O'Connor BM, Warner P, Calvert AH.
    J Med Chem; 1991 Mar 24; 34(3):978-84. PubMed ID: 2002476
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  • 8. Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues.
    Thornton TJ, Jackman AL, Marsham PR, O'Connor BM, Bishop JA, Calvert AH.
    J Med Chem; 1992 Jun 12; 35(12):2321-7. PubMed ID: 1613755
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  • 9. Quinazoline antifolates thymidylate synthase inhibitors: lipophilic analogues with modification to the C2-methyl substituent.
    Hennequin LF, Boyle FT, Wardleworth JM, Marsham PR, Kimbell R, Jackman AL.
    J Med Chem; 1996 Feb 02; 39(3):695-704. PubMed ID: 8576912
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  • 10. Quinazoline antifolates inhibiting thymidylate synthase: benzoyl ring modifications.
    Jones TR, Smithers MJ, Taylor MA, Jackman AL, Calvert AH, Harland SJ, Harrap KR.
    J Med Chem; 1986 Apr 02; 29(4):468-72. PubMed ID: 3754284
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  • 11. Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency.
    Jones TR, Thornton TJ, Flinn A, Jackman AL, Newell DR, Calvert AH.
    J Med Chem; 1989 Apr 02; 32(4):847-52. PubMed ID: 2704030
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  • 12. Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
    Bavetsias V, Jackman AL, Kimbell R, Gibson W, Boyle FT, Bisset GM.
    J Med Chem; 1996 Jan 05; 39(1):73-85. PubMed ID: 8568829
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  • 13. Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.
    Jones TR, Varney MD, Webber SE, Lewis KK, Marzoni GP, Palmer CL, Kathardekar V, Welsh KM, Webber S, Matthews DA, Appelt K, Smith WW, Janson CA, Villafranca JE, Bacquet RJ, Howland EF, Booth CL, Herrmann SM, Ward RW, White J, Moomaw EW, Bartlett CA, Morse CA.
    J Med Chem; 1996 Feb 16; 39(4):904-17. PubMed ID: 8632414
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  • 14. Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.
    Marsham PR, Wardleworth JM, Boyle FT, Hennequin LF, Kimbell R, Brown M, Jackman AL.
    J Med Chem; 1999 Sep 23; 42(19):3809-20. PubMed ID: 10508430
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  • 15. Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines.
    McNamara DJ, Berman EM, Fry DW, Werbel LM.
    J Med Chem; 1990 Jul 23; 33(7):2045-51. PubMed ID: 2362285
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  • 16. Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series.
    Marsham PR, Jackman AL, Hayter AJ, Daw MR, Snowden JL, O'Connor BM, Bishop JA, Calvert AH, Hughes LR.
    J Med Chem; 1991 Jul 23; 34(7):2209-18. PubMed ID: 2066994
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  • 17. Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent.
    Jones TR, Calvert AH, Jackman AL, Eakin MA, Smithers MJ, Betteridge RF, Newell DR, Hayter AJ, Stocker A, Harland SJ.
    J Med Chem; 1985 Oct 23; 28(10):1468-76. PubMed ID: 4045922
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  • 18. Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications.
    Marsham PR, Hughes LR, Jackman AL, Hayter AJ, Oldfield J, Wardleworth JM, Bishop JA, O'Connor BM, Calvert AH.
    J Med Chem; 1991 May 23; 34(5):1594-605. PubMed ID: 2033585
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  • 19. Quinazoline antifolates inhibiting thymidylate synthase: variation of the amino acid.
    Jones TR, Smithers MJ, Betteridge RF, Taylor MA, Jackman AL, Calvert AH, Davies LC, Harrap KR.
    J Med Chem; 1986 Jun 23; 29(6):1114-8. PubMed ID: 3712376
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  • 20. Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583).
    Bavetsias V, Jackman AL, Thornton TJ, Pawelczak K, Boyle FT, Bisset GM.
    Adv Exp Med Biol; 1993 Jun 23; 338():593-6. PubMed ID: 8304188
    [No Abstract] [Full Text] [Related]

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