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271 related items for PubMed ID: 2231606

  • 21. Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents(,).
    Bavetsias V, Marriott JH, Melin C, Kimbell R, Matusiak ZS, Boyle FT, Jackman AL.
    J Med Chem; 2000 May 18; 43(10):1910-26. PubMed ID: 10821704
    [Abstract] [Full Text] [Related]

  • 22. Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.
    Piper JR, Malik ND, Rhee MS, Galivan J, Sirotnak FM.
    J Med Chem; 1992 Jan 24; 35(2):332-7. PubMed ID: 1732551
    [Abstract] [Full Text] [Related]

  • 23. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
    Jackman AL, Taylor GA, Gibson W, Kimbell R, Brown M, Calvert AH, Judson IR, Hughes LR.
    Cancer Res; 1991 Oct 15; 51(20):5579-86. PubMed ID: 1913676
    [Abstract] [Full Text] [Related]

  • 24. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
    Rosowsky A, Galivan J, Beardsley GP, Bader H, O'Connor BM, Russello O, Moroson BA, DeYarman MT, Kerwar SS, Freisheim JH.
    Cancer Res; 1992 Apr 15; 52(8):2148-55. PubMed ID: 1313737
    [Abstract] [Full Text] [Related]

  • 25. Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.
    Gangjee A, Devraj R, McGuire JJ, Kisliuk RL.
    J Med Chem; 1995 Sep 15; 38(19):3798-805. PubMed ID: 7562910
    [Abstract] [Full Text] [Related]

  • 26. 5-Arylthio-substituted 2-amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine antifolates as thymidylate synthase inhibitors and antitumor agents.
    Gangjee A, Devraj R, McGuire JJ, Kisliuk RL.
    J Med Chem; 1995 Oct 27; 38(22):4495-502. PubMed ID: 7473577
    [Abstract] [Full Text] [Related]

  • 27. Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
    Gangjee A, Lin X, Kisliuk RL, McGuire JJ.
    J Med Chem; 2005 Nov 17; 48(23):7215-22. PubMed ID: 16279780
    [Abstract] [Full Text] [Related]

  • 28. Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).
    Nair MG, Nanavati NT, Nair IG, Kisliuk RL, Gaumont Y, Hsiao MC, Kalman TI.
    J Med Chem; 1986 Sep 17; 29(9):1754-60. PubMed ID: 3091832
    [Abstract] [Full Text] [Related]

  • 29. Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates.
    Bisset GM, Pawelczak K, Jackman AL, Calvert AH, Hughes LR.
    J Med Chem; 1992 Mar 06; 35(5):859-66. PubMed ID: 1372358
    [Abstract] [Full Text] [Related]

  • 30. Prodrugs of thymidylate synthase inhibitors: potential for antibody directed enzyme prodrug therapy (ADEPT).
    Springer CJ, Bavetsias V, Jackman AL, Boyle FT, Marshall D, Pedley RB, Bisset GM.
    Anticancer Drug Des; 1996 Dec 06; 11(8):625-36. PubMed ID: 9022750
    [Abstract] [Full Text] [Related]

  • 31. Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds.
    Nair MG, Dhawan R, Ghazala M, Kalman TI, Ferone R, Gaumont Y, Kisliuk RL.
    J Med Chem; 1987 Jul 06; 30(7):1256-61. PubMed ID: 3599032
    [Abstract] [Full Text] [Related]

  • 32. Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.
    Gangjee A, Devraj R, McGuire JJ, Kisliuk RL, Queener SF, Barrows LR.
    J Med Chem; 1994 Apr 15; 37(8):1169-76. PubMed ID: 8164259
    [Abstract] [Full Text] [Related]

  • 33. Quinazoline antifolates inhibiting thymidylate synthase: computer modelling of the N10 substituent.
    Jones TR, Betteridge RF, Neidle S, Jackman AL, Calvert AH.
    Anticancer Drug Des; 1989 Mar 15; 3(4):243-8. PubMed ID: 2930626
    [Abstract] [Full Text] [Related]

  • 34. 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase.
    Gangjee A, Mavandadi F, Kisliuk RL, McGuire JJ, Queener SF.
    J Med Chem; 1996 Nov 08; 39(23):4563-8. PubMed ID: 8917644
    [Abstract] [Full Text] [Related]

  • 35. Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
    Bavetsias V, Jackman AL, Marriott JH, Kimbell R, Gibson W, Boyle FT, Bisset GM.
    J Med Chem; 1997 May 09; 40(10):1495-510. PubMed ID: 9154971
    [Abstract] [Full Text] [Related]

  • 36. Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murine (L1210) and human (W1L2) systems in vitro and in L1210 in vivo.
    Jackman AL, Taylor GA, O'Connor BM, Bishop JA, Moran RG, Calvert AH.
    Cancer Res; 1990 Sep 01; 50(17):5212-8. PubMed ID: 2386929
    [Abstract] [Full Text] [Related]

  • 37. Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.
    Jones TR, Webber SE, Varney MD, Reddy MR, Lewis KK, Kathardekar V, Mazdiyasni H, Deal J, Nguyen D, Welsh KM, Webber S, Johnston A, Matthews DA, Smith WW, Janson CA, Bacquet RJ, Howland EF, Booth CL, Herrmann SM, Ward RW, White J, Bartlett CA, Morse CA.
    J Med Chem; 1997 Feb 28; 40(5):677-83. PubMed ID: 9057854
    [Abstract] [Full Text] [Related]

  • 38. Substituted-2-desamino-2-methyl-quinazolinones. A series of novel antitumour agents.
    Boyle FT, Matusiak ZS, Hughes LR, Slater AM, Stephens TC, Smith MN, Brown M, Kimbell R, Jackman AL.
    Adv Exp Med Biol; 1993 Feb 28; 338():585-8. PubMed ID: 8304185
    [No Abstract] [Full Text] [Related]

  • 39. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent.
    Gangjee A, Yu J, McGuire JJ, Cody V, Galitsky N, Kisliuk RL, Queener SF.
    J Med Chem; 2000 Oct 19; 43(21):3837-51. PubMed ID: 11052789
    [Abstract] [Full Text] [Related]

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