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176 related items for PubMed ID: 22336385

  • 1. 1,3,4-Thiadiazole derivatives as selective inhibitors of iNOS versus nNOS: Synthesis and structure-activity dependence.
    López-Cara LC, Carrión MD, Entrena A, Gallo MA, Espinosa A, López A, Escames G, Acuña-Castroviejo D, Camacho ME.
    Eur J Med Chem; 2012 Apr; 50():129-39. PubMed ID: 22336385
    [Abstract] [Full Text] [Related]

  • 2. Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors.
    López Cara LC, Camacho ME, Carrión MD, Tapias V, Gallo MA, Escames G, Acuña-Castroviejo D, Espinosa A, Entrena A.
    Eur J Med Chem; 2009 Jun; 44(6):2655-66. PubMed ID: 19117642
    [Abstract] [Full Text] [Related]

  • 3. Pyrazoles and pyrazolines as neural and inducible nitric oxide synthase (nNOS and iNOS) potential inhibitors (III).
    Carrión MD, López Cara LC, Camacho ME, Tapias V, Escames G, Acuña-Castroviejo D, Espinosa A, Gallo MA, Entrena A.
    Eur J Med Chem; 2008 Nov; 43(11):2579-91. PubMed ID: 18325637
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  • 4. Synthesis and biological evaluation of 4,5-dihydro-1H-pyrazole derivatives as potential nNOS/iNOS selective inhibitors. Part 2: Influence of diverse substituents in both the phenyl moiety and the acyl group.
    Carrión MD, Chayah M, Entrena A, López A, Gallo MA, Acuña-Castroviejo D, Camacho ME.
    Bioorg Med Chem; 2013 Jul 15; 21(14):4132-42. PubMed ID: 23735830
    [Abstract] [Full Text] [Related]

  • 5. Design, synthesis, and evaluation of potential inhibitors of nitric oxide synthase.
    Castaño T, Encinas A, Pérez C, Castro A, Campillo NE, Gil C.
    Bioorg Med Chem; 2008 Jun 01; 16(11):6193-206. PubMed ID: 18477512
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and biological evaluation of indazole derivatives.
    Claramunt RM, López C, López A, Pérez-Medina C, Pérez-Torralba M, Alkorta I, Elguero J, Escames G, Acuña-Castroviejo D.
    Eur J Med Chem; 2011 Apr 01; 46(4):1439-47. PubMed ID: 21334118
    [Abstract] [Full Text] [Related]

  • 7. 1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors.
    Renton P, Speed J, Maddaford S, Annedi SC, Ramnauth J, Rakhit S, Andrews J.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5301-4. PubMed ID: 21813276
    [Abstract] [Full Text] [Related]

  • 8. Development of urea and thiourea kynurenamine derivatives: synthesis, molecular modeling, and biological evaluation as nitric oxide synthase inhibitors.
    Chayah M, Carrión MD, Gallo MA, Jiménez R, Duarte J, Camacho ME.
    ChemMedChem; 2015 May 15; 10(5):874-82. PubMed ID: 25801086
    [Abstract] [Full Text] [Related]

  • 9. Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.
    Payne JE, Bonnefous C, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.
    J Med Chem; 2010 Nov 11; 53(21):7739-55. PubMed ID: 20931971
    [Abstract] [Full Text] [Related]

  • 10. Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.
    Hah JM, Martásek P, Roman LJ, Silverman RB.
    J Med Chem; 2003 Apr 24; 46(9):1661-9. PubMed ID: 12699384
    [Abstract] [Full Text] [Related]

  • 11. Discovery of a series of aminopiperidines as novel iNOS inhibitors.
    Le Bourdonnec B, Leister LK, Ajello CA, Cassel JA, Seida PR, O'Hare H, Gu M, Chu GH, Tuthill PA, DeHaven RN, Dolle RE.
    Bioorg Med Chem Lett; 2008 Jan 01; 18(1):336-43. PubMed ID: 18024030
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  • 15. Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase; the identification of (2R)-2-pyrrolidinecarboxamidine as a potent and selective haem-co-ordinating inhibitor.
    Young RJ, Alderton W, Angell AD, Beswick PJ, Brown D, Chambers CL, Crowe MC, Dawson J, Hamlett CC, Hodgson ST, Kleanthous S, Knowles RG, Russell LJ, Stocker R, Woolven JM.
    Bioorg Med Chem Lett; 2011 May 15; 21(10):3037-40. PubMed ID: 21482467
    [Abstract] [Full Text] [Related]

  • 16. Quinazolinones, Quinazolinthiones, and Quinazolinimines as Nitric Oxide Synthase Inhibitors: Synthetic Study and Biological Evaluation.
    Camacho ME, Chayah M, García ME, Fernández-Sáez N, Arias F, Gallo MA, Carrión MD.
    Arch Pharm (Weinheim); 2016 Aug 15; 349(8):638-50. PubMed ID: 27328401
    [Abstract] [Full Text] [Related]

  • 17. Synthesis, bioevaluation and docking studies of new imidamide derivatives as nitric oxide synthase inhibitors.
    Arias F, Franco-Montalban F, Romero M, Carrión MD, Camacho ME.
    Bioorg Med Chem; 2021 Aug 15; 44():116294. PubMed ID: 34218000
    [Abstract] [Full Text] [Related]

  • 18. Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS).
    Annedi SC, Ramnauth J, Cossette M, Maddaford SP, Dove P, Rakhit S, Andrews JS, Porreca F.
    Bioorg Med Chem Lett; 2012 Apr 01; 22(7):2510-3. PubMed ID: 22370270
    [Abstract] [Full Text] [Related]

  • 19. Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation.
    Claramunt RM, López C, Pérez-Medina C, Pérez-Torralba M, Elguero J, Escames G, Acuña-Castroviejo D.
    Bioorg Med Chem; 2009 Sep 01; 17(17):6180-7. PubMed ID: 19679481
    [Abstract] [Full Text] [Related]

  • 20. Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.
    Symons KT, Nguyen PM, Massari ME, Anzola JV, Staszewski LM, Wang L, Yazdani N, Dorow S, Muhammad J, Sablad M, Rozenkrants N, Bonefous C, Payne JE, Rix PJ, Shiau AK, Noble SA, Smith ND, Hassig CA, Zhang Y, Rao TS.
    J Pharmacol Exp Ther; 2011 Feb 01; 336(2):468-78. PubMed ID: 21036913
    [Abstract] [Full Text] [Related]

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