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Journal Abstract Search

218 related items for PubMed ID: 22341573

  • 1. Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors α/γ dual agonists.
    Fracchiolla G, Laghezza A, Piemontese L, Parente M, Lavecchia A, Pochetti G, Montanari R, Di Giovanni C, Carbonara G, Tortorella P, Novellino E, Loiodice F.
    Bioorg Med Chem; 2012 Mar 15; 20(6):2141-51. PubMed ID: 22341573
    [Abstract] [Full Text] [Related]

  • 2. Synthesis, biological evaluation, and molecular modeling investigation of chiral phenoxyacetic acid analogues with PPARalpha and PPARgamma agonist activity.
    Fracchiolla G, Laghezza A, Piemontese L, Carbonara G, Lavecchia A, Tortorella P, Crestani M, Novellino E, Loiodice F.
    ChemMedChem; 2007 May 15; 2(5):641-54. PubMed ID: 17357171
    [Abstract] [Full Text] [Related]

  • 3. Synthesis, biological evaluation, and molecular modeling investigation of new chiral fibrates with PPARalpha and PPARgamma agonist activity.
    Pinelli A, Godio C, Laghezza A, Mitro N, Fracchiolla G, Tortorella V, Lavecchia A, Novellino E, Fruchart JC, Staels B, Crestani M, Loiodice F.
    J Med Chem; 2005 Aug 25; 48(17):5509-19. PubMed ID: 16107150
    [Abstract] [Full Text] [Related]

  • 4. Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors α/γ agonists.
    Carrieri A, Giudici M, Parente M, De Rosas M, Piemontese L, Fracchiolla G, Laghezza A, Tortorella P, Carbonara G, Lavecchia A, Gilardi F, Crestani M, Loiodice F.
    Eur J Med Chem; 2013 May 25; 63():321-32. PubMed ID: 23502212
    [Abstract] [Full Text] [Related]

  • 5. Are fish oil omega-3 long-chain fatty acids and their derivatives peroxisome proliferator-activated receptor agonists?
    Gani OA.
    Cardiovasc Diabetol; 2008 Mar 20; 7():6. PubMed ID: 18355413
    [Abstract] [Full Text] [Related]

  • 6. New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function.
    Fracchiolla G, Laghezza A, Piemontese L, Tortorella P, Mazza F, Montanari R, Pochetti G, Lavecchia A, Novellino E, Pierno S, Conte Camerino D, Loiodice F.
    J Med Chem; 2009 Oct 22; 52(20):6382-93. PubMed ID: 19775169
    [Abstract] [Full Text] [Related]

  • 7. Design, synthesis, and structure-activity relationships of piperidine and dehydropiperidine carboxylic acids as novel, potent dual PPARalpha/gamma agonists.
    Ye XY, Li YX, Farrelly D, Flynn N, Gu L, Locke KT, Lippy J, O'Malley K, Twamley C, Zhang L, Ryono DE, Zahler R, Hariharan N, Cheng PT.
    Bioorg Med Chem Lett; 2008 Jun 15; 18(12):3545-50. PubMed ID: 18511276
    [Abstract] [Full Text] [Related]

  • 8. Design and synthesis of benzoxazole containing indole analogs as peroxisome proliferator-activated receptor-γ/δ dual agonists.
    Gim HJ, Cheon YJ, Ryu JH, Jeon R.
    Bioorg Med Chem Lett; 2011 May 15; 21(10):3057-61. PubMed ID: 21482466
    [Abstract] [Full Text] [Related]

  • 9. Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARalpha and PPARgamma agonist activity.
    Fracchiolla G, Lavecchia A, Laghezza A, Piemontese L, Trisolini R, Carbonara G, Tortorella P, Novellino E, Loiodice F.
    Bioorg Med Chem; 2008 Nov 01; 16(21):9498-510. PubMed ID: 18835719
    [Abstract] [Full Text] [Related]

  • 10. Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.
    Kuwabara N, Oyama T, Tomioka D, Ohashi M, Yanagisawa J, Shimizu T, Miyachi H.
    J Med Chem; 2012 Jan 26; 55(2):893-902. PubMed ID: 22185225
    [Abstract] [Full Text] [Related]

  • 11. Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications.
    Touyz RM, Schiffrin EL.
    Vascul Pharmacol; 2006 Jul 26; 45(1):19-28. PubMed ID: 16782410
    [Abstract] [Full Text] [Related]

  • 12. Different binding and recognition modes of GL479, a dual agonist of Peroxisome Proliferator-Activated Receptor α/γ.
    dos Santos JC, Bernardes A, Giampietro L, Ammazzalorso A, De Filippis B, Amoroso R, Polikarpov I.
    J Struct Biol; 2015 Sep 26; 191(3):332-40. PubMed ID: 26185032
    [Abstract] [Full Text] [Related]

  • 13. A rapid, homogeneous, fluorescence polarization binding assay for peroxisome proliferator-activated receptors alpha and gamma using a fluorescein-tagged dual PPARalpha/gamma activator.
    Seethala R, Golla R, Ma Z, Zhang H, O'Malley K, Lippy J, Cheng L, Mookhtiar K, Farrelly D, Zhang L, Hariharan N, Cheng PT.
    Anal Biochem; 2007 Apr 15; 363(2):263-74. PubMed ID: 17335769
    [Abstract] [Full Text] [Related]

  • 14. Development of a new class of benzoylpyrrole-based PPARα/γ activators.
    Ushiroda K, Maruta K, Kitoh M, Iwai K, Nagamine J, Tsuchida A, Taiji M, Nagata R.
    Bioorg Med Chem Lett; 2011 Jan 01; 21(1):220-4. PubMed ID: 21130649
    [Abstract] [Full Text] [Related]

  • 15. Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.
    Suh YG, Kim NJ, Koo BW, Lee KO, Moon SH, Shin DH, Jung JW, Paek SM, Chang DJ, Li F, Kang HJ, Le TV, Chae YN, Shin CY, Kim MK, Lim JI, Ryu JS, Park HJ.
    J Med Chem; 2008 Oct 23; 51(20):6318-33. PubMed ID: 18826205
    [Abstract] [Full Text] [Related]

  • 16. Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach.
    D'Aniello E, Fellous T, Iannotti FA, Gentile A, Allarà M, Balestrieri F, Gray R, Amodeo P, Vitale RM, Di Marzo V.
    Biochim Biophys Acta Gen Subj; 2019 Mar 23; 1863(3):586-597. PubMed ID: 30611848
    [Abstract] [Full Text] [Related]

  • 17. Design and synthesis of novel oxazole containing 1,3-dioxane-2-carboxylic acid derivatives as PPAR alpha/gamma dual agonists.
    Pingali H, Jain M, Shah S, Makadia P, Zaware P, Goel A, Patel M, Giri S, Patel H, Patel P.
    Bioorg Med Chem; 2008 Aug 01; 16(15):7117-27. PubMed ID: 18625559
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and evaluation of 2,3-dinorprostaglandins: Dinor-PGD1 and 13-epi-dinor-PGD1 are peroxisome proliferator-activated receptor α/γ dual agonists.
    Sato A, Dodo K, Makishima M, Hashimoto Y, Sodeoka M.
    Bioorg Med Chem Lett; 2013 May 15; 23(10):3013-7. PubMed ID: 23566516
    [Abstract] [Full Text] [Related]

  • 19. Alpha-alkyl substituted pirinixic acid derivatives as potent dual agonists of the peroxisome proliferator activated receptor alpha and gamma.
    Rau O, Syha Y, Zettl H, Kock M, Bock A, Schubert-Zsilavecz M.
    Arch Pharm (Weinheim); 2008 Mar 15; 341(3):191-5. PubMed ID: 18275039
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1).
    Shibata Y, Kagechika K, Yamaguchi M, Kubo H, Usui H.
    Bioorg Med Chem Lett; 2012 Dec 01; 22(23):7075-9. PubMed ID: 23084275
    [Abstract] [Full Text] [Related]

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