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Journal Abstract Search

375 related items for PubMed ID: 22383527

  • 1. Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase.
    Montalvo-Ortiz BL, Castillo-Pichardo L, Hernández E, Humphries-Bickley T, De la Mota-Peynado A, Cubano LA, Vlaar CP, Dharmawardhane S.
    J Biol Chem; 2012 Apr 13; 287(16):13228-38. PubMed ID: 22383527
    [Abstract] [Full Text] [Related]

  • 2. Development of EHop-016: a small molecule inhibitor of Rac.
    Dharmawardhane S, Hernandez E, Vlaar C.
    Enzymes; 2013 Apr 13; 33 Pt A(Pt A):117-46. PubMed ID: 25033803
    [Abstract] [Full Text] [Related]

  • 3. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.
    Humphries-Bickley T, Castillo-Pichardo L, Hernandez-O'Farrill E, Borrero-Garcia LD, Forestier-Roman I, Gerena Y, Blanco M, Rivera-Robles MJ, Rodriguez-Medina JR, Cubano LA, Vlaar CP, Dharmawardhane S.
    Mol Cancer Ther; 2017 May 13; 16(5):805-818. PubMed ID: 28450422
    [Abstract] [Full Text] [Related]

  • 4. Novel inhibitors of Rac1 in metastatic breast cancer.
    Hernández E, De La Mota-Peynado A, Dharmawardhane S, Vlaar CP.
    P R Health Sci J; 2010 Dec 13; 29(4):348-56. PubMed ID: 21261173
    [Abstract] [Full Text] [Related]

  • 5. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.
    Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y.
    Proc Natl Acad Sci U S A; 2004 May 18; 101(20):7618-23. PubMed ID: 15128949
    [Abstract] [Full Text] [Related]

  • 6. RAC1 GTP-ase signals Wnt-beta-catenin pathway mediated integrin-directed metastasis-associated tumor cell phenotypes in triple negative breast cancers.
    De P, Carlson JH, Jepperson T, Willis S, Leyland-Jones B, Dey N.
    Oncotarget; 2017 Jan 10; 8(2):3072-3103. PubMed ID: 27902969
    [Abstract] [Full Text] [Related]

  • 7. The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.
    Castillo-Pichardo L, Humphries-Bickley T, De La Parra C, Forestier-Roman I, Martinez-Ferrer M, Hernandez E, Vlaar C, Ferrer-Acosta Y, Washington AV, Cubano LA, Rodriguez-Orengo J, Dharmawardhane S.
    Transl Oncol; 2014 Oct 10; 7(5):546-55. PubMed ID: 25389450
    [Abstract] [Full Text] [Related]

  • 8. Rac and Cdc42 inhibitors reduce macrophage function in breast cancer preclinical models.
    Torres-Sanchez A, Rivera-Robles M, Castillo-Pichardo L, Martínez-Ferrer M, Dorta-Estremera SM, Dharmawardhane S.
    Front Oncol; 2023 Oct 10; 13():1152458. PubMed ID: 37397366
    [Abstract] [Full Text] [Related]

  • 9. Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells.
    Baugher PJ, Krishnamoorthy L, Price JE, Dharmawardhane SF.
    Breast Cancer Res; 2005 Oct 10; 7(6):R965-74. PubMed ID: 16280046
    [Abstract] [Full Text] [Related]

  • 10. Characterization of Novel Derivatives of MBQ-167, an inhibitor of the GTP-binding proteins Rac/Cdc42.
    Medina JI, Cruz-Collazo A, Del Mar Maldonado M, Gascot TM, Borrero-Garcia LD, Cooke M, Kazanietz MG, O'Farril EH, Vlaar CP, Dharmawardhane S.
    Cancer Res Commun; 2022 Dec 10; 2(12):1711-1726. PubMed ID: 36861094
    [Abstract] [Full Text] [Related]

  • 11. Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer.
    Rosenblatt AE, Garcia MI, Lyons L, Xie Y, Maiorino C, Désiré L, Slingerland J, Burnstein KL.
    Endocr Relat Cancer; 2011 Apr 10; 18(2):207-19. PubMed ID: 21118977
    [Abstract] [Full Text] [Related]

  • 12. Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
    Martin H, Mali RS, Ma P, Chatterjee A, Ramdas B, Sims E, Munugalavadla V, Ghosh J, Mattingly RR, Visconte V, Tiu RV, Vlaar CP, Dharmawardhane S, Kapur R.
    J Clin Invest; 2013 Oct 10; 123(10):4449-63. PubMed ID: 24091327
    [Abstract] [Full Text] [Related]

  • 13. Rational design and applications of a Rac GTPase-specific small molecule inhibitor.
    Akbar H, Cancelas J, Williams DA, Zheng J, Zheng Y.
    Methods Enzymol; 2006 Oct 10; 406():554-65. PubMed ID: 16472687
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis and biological evaluation of new carbazole derivatives as anti-cancer and anti-migratory agents.
    Vlaar CP, Castillo-Pichardo L, Medina JI, Marrero-Serra CM, Vélez E, Ramos Z, Hernández E.
    Bioorg Med Chem; 2018 Feb 15; 26(4):884-890. PubMed ID: 29358027
    [Abstract] [Full Text] [Related]

  • 15. Enhanced intrinsic migration of aggressive breast cancer cells by inhibition of Rac1 GTPase.
    Zuo Y, Shields SK, Chakraborty C.
    Biochem Biophys Res Commun; 2006 Dec 15; 351(2):361-7. PubMed ID: 17064663
    [Abstract] [Full Text] [Related]

  • 16. Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.
    Morrison Joly M, Williams MM, Hicks DJ, Jones B, Sanchez V, Young CD, Sarbassov DD, Muller WJ, Brantley-Sieders D, Cook RS.
    Breast Cancer Res; 2017 Jun 30; 19(1):74. PubMed ID: 28666462
    [Abstract] [Full Text] [Related]

  • 17. Blockade of Rac1 activity induces G1 cell cycle arrest or apoptosis in breast cancer cells through downregulation of cyclin D1, survivin, and X-linked inhibitor of apoptosis protein.
    Yoshida T, Zhang Y, Rivera Rosado LA, Chen J, Khan T, Moon SY, Zhang B.
    Mol Cancer Ther; 2010 Jun 30; 9(6):1657-68. PubMed ID: 20515940
    [Abstract] [Full Text] [Related]

  • 18. Activation of Dbl restores migration in polyamine-depleted intestinal epithelial cells via Rho-GTPases.
    Ray RM, Bavaria MN, Bhattacharya S, Johnson LR.
    Am J Physiol Gastrointest Liver Physiol; 2011 Jun 30; 300(6):G988-97. PubMed ID: 21372162
    [Abstract] [Full Text] [Related]

  • 19. Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.
    Debreceni B, Gao Y, Guo F, Zhu K, Jia B, Zheng Y.
    J Biol Chem; 2004 Jan 30; 279(5):3777-86. PubMed ID: 14597635
    [Abstract] [Full Text] [Related]

  • 20. Structure-function based design of small molecule inhibitors targeting Rho family GTPases.
    Nassar N, Cancelas J, Zheng J, Williams DA, Zheng Y.
    Curr Top Med Chem; 2006 Jan 30; 6(11):1109-16. PubMed ID: 16842149
    [Abstract] [Full Text] [Related]

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