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Journal Abstract Search

142 related items for PubMed ID: 2242019

  • 1. Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.
    Bai RL, Pettit GR, Hamel E.
    Biochem Pharmacol; 1990 Oct 15; 40(8):1859-64. PubMed ID: 2242019
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  • 2. Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity.
    Bai R, Roach MC, Jayaram SK, Barkoczy J, Pettit GR, Ludueña RF, Hamel E.
    Biochem Pharmacol; 1993 Apr 06; 45(7):1503-15. PubMed ID: 8471072
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  • 3. Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.
    Bai R, Friedman SJ, Pettit GR, Hamel E.
    Biochem Pharmacol; 1992 Jun 23; 43(12):2637-45. PubMed ID: 1632820
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  • 4. Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.
    Bai R, Pettit GR, Hamel E.
    Biochem Pharmacol; 1990 Jun 15; 39(12):1941-9. PubMed ID: 2353935
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  • 5. The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.
    Bai R, Taylor GF, Cichacz ZA, Herald CL, Kepler JA, Pettit GR, Hamel E.
    Biochemistry; 1995 Aug 01; 34(30):9714-21. PubMed ID: 7626642
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  • 8. Antineoplastic agents 365. Dolastatin 10 SAR probes.
    Pettit GR, Srirangam JK, Barkoczy J, Williams MD, Boyd MR, Hamel E, Pettit RK, Hogan F, Bai R, Chapuis JC, McAllister SC, Schmidt JM.
    Anticancer Drug Des; 1998 Jun 01; 13(4):243-77. PubMed ID: 9627667
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  • 9. Growth inhibition of human lymphoma cell lines by the marine products, dolastatins 10 and 15.
    Beckwith M, Urba WJ, Longo DL.
    J Natl Cancer Inst; 1993 Mar 17; 85(6):483-8. PubMed ID: 8445676
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  • 10. Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.
    Bai R, Cichacz ZA, Herald CL, Pettit GR, Hamel E.
    Mol Pharmacol; 1993 Oct 17; 44(4):757-66. PubMed ID: 8232226
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  • 11. Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity.
    Verdier-Pinard P, Kepler JA, Pettit GR, Hamel E.
    Mol Pharmacol; 2000 Jan 17; 57(1):180-7. PubMed ID: 10617693
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  • 12. Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay.
    Aherne GW, Hardcastle A, Valenti M, Bryant A, Rogers P, Pettit GR, Srirangam JK, Kelland LR.
    Cancer Chemother Pharmacol; 1996 Jan 17; 38(3):225-32. PubMed ID: 8646796
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  • 13. Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1.
    Bai R, Durso NA, Sackett DL, Hamel E.
    Biochemistry; 1999 Oct 26; 38(43):14302-10. PubMed ID: 10572005
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  • 14. Antineoplastic agents 360. Synthesis and cancer cell growth inhibitory studies of dolastatin 15 structural modifications.
    Pettit GR, Flahive EJ, Boyd MR, Bai R, Hamel E, Pettit RK, Schmidt JM.
    Anticancer Drug Des; 1998 Jan 26; 13(1):47-66. PubMed ID: 9474242
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  • 17. Treatment of human prostate cancer cells with dolastatin 10, a peptide isolated from a marine shell-less mollusc.
    Turner T, Jackson WH, Pettit GR, Wells A, Kraft AS.
    Prostate; 1998 Feb 15; 34(3):175-81. PubMed ID: 9492845
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  • 18. Interaction of marine toxin dolastatin 10 with porcine brain tubulin: competitive inhibition of rhizoxin and phomopsin A binding.
    Li Y, Kobayashi H, Hashimoto Y, Shirai R, Hirata A, Hayashi K, Hamada Y, Shioiri T, Iwasaki S.
    Chem Biol Interact; 1994 Dec 15; 93(3):175-83. PubMed ID: 7923438
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  • 19. Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.
    Cruz-Monserrate Z, Vervoort HC, Bai R, Newman DJ, Howell SB, Los G, Mullaney JT, Williams MD, Pettit GR, Fenical W, Hamel E.
    Mol Pharmacol; 2003 Jun 15; 63(6):1273-80. PubMed ID: 12761336
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