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Journal Abstract Search

105 related items for PubMed ID: 22424974

  • 1. Discovery of new piperidine amide triazolobenzodiazepinones as intestinal-selective CCK1 receptor agonists.
    Cameron KO, Beretta EE, Chen Y, Chu-Moyer M, Fernando D, Gao H, Kohrt J, Lavergne S, Jardine Pda S, Guzman-Perez A, Hoth C, Perry DA, Hadcock JR, Gautreau D, Makowski M, Perez S, Polivkova J, Rogers L, Scott DO, Swick AG, Thiede L, Trebino CE, Trilles RV, Wilmowski J, Zhang Y.
    Bioorg Med Chem Lett; 2012 Apr 15; 22(8):2943-7. PubMed ID: 22424974
    [Abstract] [Full Text] [Related]

  • 2. Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.
    Wang L, Hubert JA, Lee SJ, Pan J, Qian S, Reitman ML, Strack AM, Weingarth DT, MacNeil DJ, Weber AE, Edmondson SD.
    Bioorg Med Chem Lett; 2011 May 15; 21(10):2911-5. PubMed ID: 21493064
    [Abstract] [Full Text] [Related]

  • 3. Discovery of imidazole carboxamides as potent and selective CCK1R agonists.
    Zhu C, Hansen AR, Bateman T, Chen Z, Holt TG, Hubert JA, Karanam BV, Lee SJ, Pan J, Qian S, Reddy VB, Reitman ML, Strack AM, Tong V, Weingarth DT, Wolff MS, MacNeil DJ, Weber AE, Duffy JL, Edmondson SD.
    Bioorg Med Chem Lett; 2008 Aug 01; 18(15):4393-6. PubMed ID: 18614364
    [Abstract] [Full Text] [Related]

  • 4. Discovery of piperidine carboxamide TRPV1 antagonists.
    Cheung WS, Calvo RR, Tounge BA, Zhang SP, Stone DR, Brandt MR, Hutchinson T, Flores CM, Player MR.
    Bioorg Med Chem Lett; 2008 Aug 15; 18(16):4569-72. PubMed ID: 18662879
    [Abstract] [Full Text] [Related]

  • 5. Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.
    Thalji RK, McAtee JJ, Belyanskaya S, Brandt M, Brown GD, Costell MH, Ding Y, Dodson JW, Eisennagel SH, Fries RE, Gross JW, Harpel MR, Holt DA, Israel DI, Jolivette LJ, Krosky D, Li H, Lu Q, Mandichak T, Roethke T, Schnackenberg CG, Schwartz B, Shewchuk LM, Xie W, Behm DJ, Douglas SA, Shaw AL, Marino JP.
    Bioorg Med Chem Lett; 2013 Jun 15; 23(12):3584-8. PubMed ID: 23664879
    [Abstract] [Full Text] [Related]

  • 6. Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents.
    Fong TM, Guan XM, Marsh DJ, Shen CP, Stribling DS, Rosko KM, Lao J, Yu H, Feng Y, Xiao JC, Van der Ploeg LH, Goulet MT, Hagmann WK, Lin LS, Lanza TJ, Jewell JP, Liu P, Shah SK, Qi H, Tong X, Wang J, Xu SS, Francis B, Strack AM, MacIntyre DE, Shearman LP.
    J Pharmacol Exp Ther; 2007 Jun 15; 321(3):1013-22. PubMed ID: 17327489
    [Abstract] [Full Text] [Related]

  • 7. The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: antagonists versus agonists.
    Ting PC, Umland SP, Aslanian R, Cao J, Garlisi CG, Huang Y, Jakway J, Liu Z, Shah H, Tian F, Wan Y, Shih NY.
    Bioorg Med Chem Lett; 2005 Jun 15; 15(12):3020-3. PubMed ID: 15908209
    [Abstract] [Full Text] [Related]

  • 8. Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands.
    Li G, Zhou H, Jiang Y, Keim H, Topiol SW, Poda SB, Ren Y, Chandrasena G, Doller D.
    Bioorg Med Chem Lett; 2011 Feb 15; 21(4):1236-42. PubMed ID: 21237644
    [Abstract] [Full Text] [Related]

  • 9. Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists.
    Yang L, Butora G, Jiao RX, Pasternak A, Zhou C, Parsons WH, Mills SG, Vicario PP, Ayala JM, Cascieri MA, MacCoss M.
    J Med Chem; 2007 May 31; 50(11):2609-11. PubMed ID: 17461566
    [Abstract] [Full Text] [Related]

  • 10. Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists I: discovery of CCKR1 selectivity in a previously CCKR2-selective lead series.
    Pippel M, Allison BD, Phuong VK, Li L, Morton MF, Prendergast C, Wu X, Shankley NP, Rabinowitz MH.
    Bioorg Med Chem Lett; 2009 Nov 15; 19(22):6373-5. PubMed ID: 19811913
    [Abstract] [Full Text] [Related]

  • 11. Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
    Guo L, Ye Z, Liu J, He S, Bakshi RK, Sebhat IK, Dobbelaar PH, Hong Q, Jian T, Dellureficio JP, Tsou NN, Ball RG, Weinberg DH, MacNeil T, Tang R, Tamvakopoulos C, Peng Q, Chen HY, Chen AS, Martin WJ, MacIntyre DE, Strack AM, Fong TM, Wyvratt MJ, Nargund RP.
    Bioorg Med Chem Lett; 2010 Aug 15; 20(16):4895-900. PubMed ID: 20621473
    [Abstract] [Full Text] [Related]

  • 12. Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists.
    Li FN, Kim NJ, Paek SM, Kwon DY, Min KH, Jeong YS, Kim SY, Park YH, Kim HD, Park HG, Suh YG.
    Bioorg Med Chem; 2009 May 15; 17(10):3557-67. PubMed ID: 19398205
    [Abstract] [Full Text] [Related]

  • 13. Design and synthesis of pyridin-2-ylmethylaminopiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication.
    Skerlj R, Bridger G, Zhou Y, Bourque E, McEachern E, Langille J, Harwig C, Veale D, Yang W, Li T, Zhu Y, Bey M, Baird I, Sartori M, Metz M, Mosi R, Nelson K, Bodart V, Wong R, Fricker S, Mac Farland R, Huskens D, Schols D.
    Bioorg Med Chem Lett; 2011 Dec 01; 21(23):6950-4. PubMed ID: 22033460
    [Abstract] [Full Text] [Related]

  • 14. Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
    Yang ZQ, Barrow JC, Shipe WD, Schlegel KA, Shu Y, Yang FV, Lindsley CW, Rittle KE, Bock MG, Hartman GD, Uebele VN, Nuss CE, Fox SV, Kraus RL, Doran SM, Connolly TM, Tang C, Ballard JE, Kuo Y, Adarayan ED, Prueksaritanont T, Zrada MM, Marino MJ, Graufelds VK, DiLella AG, Reynolds IJ, Vargas HM, Bunting PB, Woltmann RF, Magee MM, Koblan KS, Renger JJ.
    J Med Chem; 2008 Oct 23; 51(20):6471-7. PubMed ID: 18817368
    [Abstract] [Full Text] [Related]

  • 15. SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. II. In vivo pharmacological characterization.
    Bignon E, Alonso R, Arnone M, Boigegrain R, Brodin R, Gueudet C, Héaulme M, Keane P, Landi M, Molimard JC, Olliero D, Poncelet M, Seban E, Simiand J, Soubrié P, Pascal M, Maffrand JP, Le Fur G.
    J Pharmacol Exp Ther; 1999 May 23; 289(2):752-61. PubMed ID: 10215649
    [Abstract] [Full Text] [Related]

  • 16. Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.
    Suzuki T, Moriya M, Sakamoto T, Suga T, Kishino H, Takahashi H, Ishikawa M, Nagai K, Imai Y, Sekino E, Ito M, Iwaasa H, Ishihara A, Tokita S, Kanatani A, Sato N, Fukami T.
    Bioorg Med Chem Lett; 2009 Jun 01; 19(11):3072-7. PubMed ID: 19403308
    [Abstract] [Full Text] [Related]

  • 17. 2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.
    Berger R, Zhu C, Hansen AR, Harper B, Chen Z, Holt TG, Hubert J, Lee SJ, Pan J, Qian S, Reitman ML, Strack AM, Weingarth DT, Wolff M, Macneil DJ, Weber AE, Edmondson SD.
    Bioorg Med Chem Lett; 2008 Sep 01; 18(17):4833-7. PubMed ID: 18684621
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamides as TRPM8 antagonists.
    Chaudhari SS, Kadam AB, Khairatkar-Joshi N, Mukhopadhyay I, Karnik PV, Raghuram A, Rao SS, Vaiyapuri TS, Wale DP, Bhosale VM, Gudi GS, Sangana RR, Thomas A.
    Bioorg Med Chem; 2013 Nov 01; 21(21):6542-53. PubMed ID: 24055075
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice.
    Zhang L, Chen J, Ning M, Zou Q, Leng Y, Shen J.
    Bioorg Med Chem Lett; 2012 Apr 15; 22(8):2748-52. PubMed ID: 22440625
    [Abstract] [Full Text] [Related]

  • 20. Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.
    He S, Ye Z, Dobbelaar PH, Sebhat IK, Guo L, Liu J, Jian T, Lai Y, Franklin CL, Bakshi RK, Dellureficio JP, Hong Q, Weinberg DH, Macneil T, Tang R, Strack AM, Tamvakopoulos C, Peng Q, Miller RR, Stearns RA, Chen HY, Chen AS, Fong TM, Wyvratt MJ, Nargund RP.
    Bioorg Med Chem Lett; 2010 Aug 01; 20(15):4399-405. PubMed ID: 20598882
    [Abstract] [Full Text] [Related]

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