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Journal Abstract Search

297 related items for PubMed ID: 22429491

  • 1. Insulin-like growth factor 1 attenuates antiestrogen- and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim.
    Periyasamy-Thandavan S, Takhar S, Singer A, Dohn MR, Jackson WH, Welborn AE, LeRoith D, Marrero M, Thangaraju M, Huang S, Schoenlein PV.
    Breast Cancer Res; 2012 Mar 19; 14(2):R52. PubMed ID: 22429491
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  • 3. Downregulation of retinoblastoma protein is involved in the enhanced cytotoxicity of 4-hydroxytamoxifen plus mifepristone combination therapy versus antiestrogen monotherapy of human breast cancer.
    Schoenlein PV, Hou M, Samaddar JS, Gaddy VT, Thangaraju M, Lewis J, Johnson M, Ganapathy V, Kallab A, Barrett JT.
    Int J Oncol; 2007 Sep 19; 31(3):643-55. PubMed ID: 17671693
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  • 4. MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism.
    Pei XY, Dai Y, Tenorio S, Lu J, Harada H, Dent P, Grant S.
    Blood; 2007 Sep 15; 110(6):2092-101. PubMed ID: 17540843
    [Abstract] [Full Text] [Related]

  • 5. Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism.
    Roberts CG, Gurisik E, Biden TJ, Sutherland RL, Butt AJ.
    Mol Cancer Ther; 2007 Oct 15; 6(10):2777-85. PubMed ID: 17913853
    [Abstract] [Full Text] [Related]

  • 6. Induction of antiproliferation and apoptosis in estrogen receptor negative MDA-231 human breast cancer cells by mifepristone and 4-hydroxytamoxifen combination therapy: a role for TGFbeta1.
    Liang Y, Hou M, Kallab AM, Barrett JT, El Etreby F, Schoenlein PV.
    Int J Oncol; 2003 Aug 15; 23(2):369-80. PubMed ID: 12851686
    [Abstract] [Full Text] [Related]

  • 7. Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation.
    Fox EM, Kuba MG, Miller TW, Davies BR, Arteaga CL.
    Breast Cancer Res; 2013 Aug 15; 15(4):R55. PubMed ID: 23844554
    [Abstract] [Full Text] [Related]

  • 8. Additive effect of mifepristone and tamoxifen on apoptotic pathways in MCF-7 human breast cancer cells.
    El Etreby MF, Liang Y, Wrenn RW, Schoenlein PV.
    Breast Cancer Res Treat; 1998 Sep 15; 51(2):149-68. PubMed ID: 9879777
    [Abstract] [Full Text] [Related]

  • 9. PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.
    Park SH, Ito K, Olcott W, Katsyv I, Halstead-Nussloch G, Irie HY.
    Breast Cancer Res; 2015 Jun 19; 17(1):86. PubMed ID: 26084280
    [Abstract] [Full Text] [Related]

  • 10. G1P3, an interferon- and estrogen-induced survival protein contributes to hyperplasia, tamoxifen resistance and poor outcomes in breast cancer.
    Cheriyath V, Kuhns MA, Jacobs BS, Evangelista P, Elson P, Downs-Kelly E, Tubbs R, Borden EC.
    Oncogene; 2012 Apr 26; 31(17):2222-36. PubMed ID: 21996729
    [Abstract] [Full Text] [Related]

  • 11. Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes.
    Zhang Y, Moerkens M, Ramaiahgari S, de Bont H, Price L, Meerman J, van de Water B.
    Breast Cancer Res; 2011 May 19; 13(3):R52. PubMed ID: 21595894
    [Abstract] [Full Text] [Related]

  • 12. Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation.
    Lewis JS, Meeke K, Osipo C, Ross EA, Kidawi N, Li T, Bell E, Chandel NS, Jordan VC.
    J Natl Cancer Inst; 2005 Dec 07; 97(23):1746-59. PubMed ID: 16333030
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  • 14. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.
    Campbell RA, Bhat-Nakshatri P, Patel NM, Constantinidou D, Ali S, Nakshatri H.
    J Biol Chem; 2001 Mar 30; 276(13):9817-24. PubMed ID: 11139588
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  • 16. Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim.
    Meng J, Fang B, Liao Y, Chresta CM, Smith PD, Roth JA.
    PLoS One; 2010 Sep 27; 5(9):e13026. PubMed ID: 20885957
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  • 17. MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM.
    Rambal AA, Panaguiton ZL, Kramer L, Grant S, Harada H.
    Leukemia; 2009 Oct 27; 23(10):1744-54. PubMed ID: 19404317
    [Abstract] [Full Text] [Related]

  • 18. ON-III inhibits erbB-2 tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast cancer cells.
    Li DD, Wu XQ, Tang J, Wei XY, Zhu XF.
    Cancer Biol Ther; 2009 Apr 27; 8(8):739-43. PubMed ID: 19242112
    [Abstract] [Full Text] [Related]

  • 19. A kinase inhibitor screen reveals MEK1/2 as a novel therapeutic target to antagonize IGF1R-mediated antiestrogen resistance in ERα-positive luminal breast cancer.
    Wester L, Venneker S, Hazenoot M, Pont C, Koedoot E, Timmermans AM, Martens JWM, Jansen MPHM, Kockx CEM, van IJcken WFJ, Meerman JHN, Zhang Y, van de Water B.
    Biochem Pharmacol; 2022 Oct 27; 204():115233. PubMed ID: 36041543
    [Abstract] [Full Text] [Related]

  • 20. Identification of PUMA as an estrogen target gene that mediates the apoptotic response to tamoxifen in human breast cancer cells and predicts patient outcome and tamoxifen responsiveness in breast cancer.
    Roberts CG, Millar EK, O'Toole SA, McNeil CM, Lehrbach GM, Pinese M, Tobelmann P, McCloy RA, Musgrove EA, Sutherland RL, Butt AJ.
    Oncogene; 2011 Jul 14; 30(28):3186-97. PubMed ID: 21383694
    [Abstract] [Full Text] [Related]

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