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Journal Abstract Search

166 related items for PubMed ID: 22440625

  • 1. Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice.
    Zhang L, Chen J, Ning M, Zou Q, Leng Y, Shen J.
    Bioorg Med Chem Lett; 2012 Apr 15; 22(8):2748-52. PubMed ID: 22440625
    [Abstract] [Full Text] [Related]

  • 2. 4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice.
    Zhang X, Zhou Z, Yang H, Chen J, Feng Y, Du L, Leng Y, Shen J.
    Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4455-8. PubMed ID: 19564108
    [Abstract] [Full Text] [Related]

  • 3. Piperidine amides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
    Flyrén K, Bergquist LO, Castro VM, Fotsch C, Johansson L, St Jean DJ, Sutin L, Williams M.
    Bioorg Med Chem Lett; 2007 Jun 15; 17(12):3421-5. PubMed ID: 17442567
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis and SAR of piperidyl-oxadiazoles as 11β-hydroxysteroid dehydrogenase 1 inhibitors.
    Xia G, You X, Liu L, Liu H, Wang J, Shi Y, Li P, Xiong B, Liu X, Shen J.
    Eur J Med Chem; 2013 Apr 15; 62():1-10. PubMed ID: 23353742
    [Abstract] [Full Text] [Related]

  • 5. Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling.
    Yang H, Dou W, Lou J, Leng Y, Shen J.
    Bioorg Med Chem Lett; 2008 Feb 15; 18(4):1340-5. PubMed ID: 18242087
    [Abstract] [Full Text] [Related]

  • 6. Benzothiazole derivatives as novel inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
    Su X, Vicker N, Ganeshapillai D, Smith A, Purohit A, Reed MJ, Potter BV.
    Mol Cell Endocrinol; 2006 Mar 27; 248(1-2):214-7. PubMed ID: 16325333
    [Abstract] [Full Text] [Related]

  • 7. Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors.
    Gaware R, Khunt R, Czollner L, Stanetty C, Da Cunha T, Kratschmar DV, Odermatt A, Kosma P, Jordis U, Classen-Houben D.
    Bioorg Med Chem; 2011 Mar 15; 19(6):1866-80. PubMed ID: 21376605
    [Abstract] [Full Text] [Related]

  • 8. Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344).
    Park JS, Rhee SD, Kang NS, Jung WH, Kim HY, Kim JH, Kang SK, Cheon HG, Ahn JH, Kim KY.
    Biochem Pharmacol; 2011 Apr 15; 81(8):1028-35. PubMed ID: 21315688
    [Abstract] [Full Text] [Related]

  • 9. Diazepane-acetamide derivatives as selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
    Odermatt A.
    Expert Opin Ther Pat; 2009 Oct 15; 19(10):1477-83. PubMed ID: 19780703
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.
    Yeh VS, Kurukulasuriya R, Madar D, Patel JR, Fung S, Monzon K, Chiou W, Wang J, Jacobson P, Sham HL, Link JT.
    Bioorg Med Chem Lett; 2006 Oct 15; 16(20):5408-13. PubMed ID: 16890427
    [Abstract] [Full Text] [Related]

  • 11. Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1.
    Venier O, Pascal C, Braun A, Namane C, Mougenot P, Crespin O, Pacquet F, Mougenot C, Monseau C, Onofri B, Dadji-Faïhun R, Leger C, Ben-Hassine M, Van-Pham T, Ragot JL, Philippo C, Güssregen S, Engel C, Farjot G, Noah L, Maniani K, Nicolaï E.
    Bioorg Med Chem Lett; 2011 Apr 15; 21(8):2244-51. PubMed ID: 21439819
    [Abstract] [Full Text] [Related]

  • 12. Discovery of novel sulfonamides as potent and selective inhibitors against human and mouse 11β-hydroxysteroid dehydrogenase type 1.
    Xia G, Liu L, Xue M, Liu H, Yu J, Li P, Chen Q, Xiong B, Liu X, Shen J.
    Mol Cell Endocrinol; 2012 Jul 06; 358(1):46-52. PubMed ID: 22410288
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.
    Yeh VS, Patel JR, Yong H, Kurukulasuriya R, Fung S, Monzon K, Chiou W, Wang J, Stolarik D, Imade H, Beno D, Brune M, Jacobson P, Sham H, Link JT.
    Bioorg Med Chem Lett; 2006 Oct 15; 16(20):5414-9. PubMed ID: 16899366
    [Abstract] [Full Text] [Related]

  • 14. Adamantyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
    Olson S, Aster SD, Brown K, Carbin L, Graham DW, Hermanowski-Vosatka A, LeGrand CB, Mundt SS, Robbins MA, Schaeffer JM, Slossberg LH, Szymonifka MJ, Thieringer R, Wright SD, Balkovec JM.
    Bioorg Med Chem Lett; 2005 Oct 01; 15(19):4359-62. PubMed ID: 16039856
    [Abstract] [Full Text] [Related]

  • 15. Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
    Wan ZK, Chenail E, Xiang J, Li HQ, Ipek M, Bard J, Svenson K, Mansour TS, Xu X, Tian X, Suri V, Hahm S, Xing Y, Johnson CE, Li X, Qadri A, Panza D, Perreault M, Tobin JF, Saiah E.
    J Med Chem; 2009 Sep 10; 52(17):5449-61. PubMed ID: 19673466
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
    Xiang J, Ipek M, Suri V, Massefski W, Pan N, Ge Y, Tam M, Xing Y, Tobin JF, Xu X, Tam S.
    Bioorg Med Chem Lett; 2005 Jun 02; 15(11):2865-9. PubMed ID: 15911270
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11β-hydroxysteroid dehydrogenase 1 inhibitors.
    Hofer S, Kratschmar DV, Schernthanner B, Vuorinen A, Schuster D, Odermatt A, Easmon J.
    Bioorg Med Chem Lett; 2013 Oct 01; 23(19):5397-400. PubMed ID: 23981897
    [Abstract] [Full Text] [Related]

  • 18. Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
    Roche D, Carniato D, Leriche C, Lepifre F, Christmann-Franck S, Graedler U, Charon C, Bozec S, Doare L, Schmidlin F, Lecomte M, Valeur E.
    Bioorg Med Chem Lett; 2009 May 15; 19(10):2674-8. PubMed ID: 19395260
    [Abstract] [Full Text] [Related]

  • 19. Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors.
    Shah U, Boyle CD, Chackalamannil S, Baker H, Kowalski T, Lee J, Terracina G, Zhang L.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1551-4. PubMed ID: 20149650
    [Abstract] [Full Text] [Related]

  • 20. Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
    Sun D, Wang Z, Di Y, Jaen JC, Labelle M, Ma J, Miao S, Sudom A, Tang L, Tomooka CS, Tu H, Ursu S, Walker N, Yan X, Ye Q, Powers JP.
    Bioorg Med Chem Lett; 2008 Jun 15; 18(12):3513-6. PubMed ID: 18511278
    [Abstract] [Full Text] [Related]

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