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Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

96 related items for PubMed ID: 22444683

  • 21. Discovery and characterization of a novel potent, selective and orally active inhibitor for mammalian ELOVL6.
    Shimamura K, Nagumo A, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S.
    Eur J Pharmacol; 2010 Mar 25; 630(1-3):34-41. PubMed ID: 20045404
    [Abstract] [Full Text] [Related]

  • 22. Discovery of a new class of glucosylceramide synthase inhibitors.
    Koltun E, Richards S, Chan V, Nachtigall J, Du H, Noson K, Galan A, Aay N, Hanel A, Harrison A, Zhang J, Won KA, Tam D, Qian F, Wang T, Finn P, Ogilvie K, Rosen J, Mohan R, Larson C, Lamb P, Nuss J, Kearney P.
    Bioorg Med Chem Lett; 2011 Nov 15; 21(22):6773-7. PubMed ID: 21974949
    [Abstract] [Full Text] [Related]

  • 23. Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors.
    Patel D, Jain M, Shah SR, Bahekar R, Jadav P, Joharapurkar A, Dhanesha N, Shaikh M, Sairam KV, Kapadnis P.
    Bioorg Med Chem Lett; 2012 Jan 15; 22(2):1111-7. PubMed ID: 22189136
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  • 24. Pyrazoloquinolines as PDE10A inhibitors: discovery of a tool compound.
    McElroy WT, Tan Z, Basu K, Yang SW, Smotryski J, Ho GD, Tulshian D, Greenlee WJ, Mullins D, Guzzi M, Zhang X, Bleickardt C, Hodgson R.
    Bioorg Med Chem Lett; 2012 Feb 01; 22(3):1335-9. PubMed ID: 22227212
    [Abstract] [Full Text] [Related]

  • 25. Discovery of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as glutamine fructose-6-phosphate amidotransferase (GFAT) inhibitors.
    Qian Y, Ahmad M, Chen S, Gillespie P, Le N, Mennona F, Mischke S, So SS, Wang H, Burghardt C, Tannu S, Conde-Knape K, Kochan J, Bolin D.
    Bioorg Med Chem Lett; 2011 Nov 01; 21(21):6264-9. PubMed ID: 21958546
    [Abstract] [Full Text] [Related]

  • 26. Synthesis and biological evaluation of new derivatives of 2-substituted 4-hydroxybutanamides as GABA uptake inhibitors.
    Kulig K, Więckowski K, Więckowska A, Gajda J, Pochwat B, Höfner GC, Wanner KT, Malawska B.
    Eur J Med Chem; 2011 Jan 01; 46(1):183-90. PubMed ID: 21111516
    [Abstract] [Full Text] [Related]

  • 27. Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD).
    Moffett K, Konteatis Z, Nguyen D, Shetty R, Ludington J, Fujimoto T, Lee KJ, Chai X, Namboodiri H, Karpusas M, Dorsey B, Guarnieri F, Bukhtiyarova M, Springman E, Michelotti E.
    Bioorg Med Chem Lett; 2011 Dec 01; 21(23):7155-65. PubMed ID: 22014550
    [Abstract] [Full Text] [Related]

  • 28. Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.
    Bannwart LM, Carter DS, Cai HY, Choy JC, Greenhouse R, Jaime-Figueroa S, Iyer PS, Lin CJ, Lee EK, Lucas MC, Lynch SM, Madera AM, Moore A, Ozboya K, Raptova L, Roetz R, Schoenfeld RC, Stein KA, Steiner S, Villa M, Weikert RJ, Zhai Y.
    Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6062-6. PubMed ID: 18954985
    [Abstract] [Full Text] [Related]

  • 29. Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).
    Chowdhury S, Sessions EH, Pocas JR, Grant W, Schröter T, Lin L, Ruiz C, Cameron MD, Schürer S, LoGrasso P, Bannister TD, Feng Y.
    Bioorg Med Chem Lett; 2011 Dec 01; 21(23):7107-12. PubMed ID: 22004718
    [Abstract] [Full Text] [Related]

  • 30. Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model.
    Yue EW, Douty B, Wayland B, Bower M, Liu X, Leffet L, Wang Q, Bowman KJ, Hansbury MJ, Liu C, Wei M, Li Y, Wynn R, Burn TC, Koblish HK, Fridman JS, Metcalf B, Scherle PA, Combs AP.
    J Med Chem; 2009 Dec 10; 52(23):7364-7. PubMed ID: 19507862
    [Abstract] [Full Text] [Related]

  • 31. Structure-based virtual screening approach to the discovery of phosphoinositide 3-kinase alpha inhibitors.
    Park H, Choi H, Hong S, Kim D, Oh DS, Hong S.
    Bioorg Med Chem Lett; 2011 Apr 01; 21(7):2021-4. PubMed ID: 21354792
    [Abstract] [Full Text] [Related]

  • 32. Discovery of novel SCD1 inhibitors: 5-alkyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] analogs.
    Uto Y, Ueno Y, Kiyotsuka Y, Miyazawa Y, Kurata H, Ogata T, Takagi T, Wakimoto S, Ohsumi J.
    Eur J Med Chem; 2011 May 01; 46(5):1892-6. PubMed ID: 21356569
    [Abstract] [Full Text] [Related]

  • 33. Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation.
    Park JH, Jung Y, Kim TY, Kim SG, Jong HS, Lee JW, Kim DK, Lee JS, Kim NK, Kim TY, Bang YJ.
    Clin Cancer Res; 2004 Aug 01; 10(15):5271-81. PubMed ID: 15297431
    [Abstract] [Full Text] [Related]

  • 34. Discovery of 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles as potent firefly luciferase inhibitors.
    Poutiainen PK, Palvimo JJ, Hinkkanen AE, Valkonen A, Väisänen TK, Laatikainen R, Pulkkinen JT.
    J Med Chem; 2013 Feb 14; 56(3):1064-73. PubMed ID: 23286196
    [Abstract] [Full Text] [Related]

  • 35. New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis.
    Andrzejak V, Muccioli GG, Body-Malapel M, El Bakali J, Djouina M, Renault N, Chavatte P, Desreumaux P, Lambert DM, Millet R.
    Bioorg Med Chem; 2011 Jun 15; 19(12):3777-86. PubMed ID: 21612933
    [Abstract] [Full Text] [Related]

  • 36. Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
    Erlanson DA, Arndt JW, Cancilla MT, Cao K, Elling RA, English N, Friedman J, Hansen SK, Hession C, Joseph I, Kumaravel G, Lee WC, Lind KE, McDowell RS, Miatkowski K, Nguyen C, Nguyen TB, Park S, Pathan N, Penny DM, Romanowski MJ, Scott D, Silvian L, Simmons RL, Tangonan BT, Yang W, Sun L.
    Bioorg Med Chem Lett; 2011 May 15; 21(10):3078-83. PubMed ID: 21459573
    [Abstract] [Full Text] [Related]

  • 37. Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
    Wan ZK, Chenail E, Xiang J, Li HQ, Ipek M, Bard J, Svenson K, Mansour TS, Xu X, Tian X, Suri V, Hahm S, Xing Y, Johnson CE, Li X, Qadri A, Panza D, Perreault M, Tobin JF, Saiah E.
    J Med Chem; 2009 Sep 10; 52(17):5449-61. PubMed ID: 19673466
    [Abstract] [Full Text] [Related]

  • 38. Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
    Bonnefous C, Payne JE, Roppe J, Zhuang H, Chen X, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Severance D, Walsh JP, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.
    J Med Chem; 2009 May 14; 52(9):3047-62. PubMed ID: 19374401
    [Abstract] [Full Text] [Related]

  • 39. Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.
    Tsai TY, Hsu T, Chen CT, Cheng JH, Chiou MC, Huang CH, Tseng YJ, Yeh TK, Huang CY, Yeh KC, Huang YW, Wu SH, Wang MH, Chen X, Chao YS, Jiaang WT.
    Bioorg Med Chem Lett; 2009 Apr 01; 19(7):1908-12. PubMed ID: 19269819
    [Abstract] [Full Text] [Related]

  • 40. Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1.
    Venier O, Pascal C, Braun A, Namane C, Mougenot P, Crespin O, Pacquet F, Mougenot C, Monseau C, Onofri B, Dadji-Faïhun R, Leger C, Ben-Hassine M, Van-Pham T, Ragot JL, Philippo C, Güssregen S, Engel C, Farjot G, Noah L, Maniani K, Nicolaï E.
    Bioorg Med Chem Lett; 2011 Apr 15; 21(8):2244-51. PubMed ID: 21439819
    [Abstract] [Full Text] [Related]

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