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296 related items for PubMed ID: 22448038

  • 1. Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression.
    Kaspar JW, Niture SK, Jaiswal AK.
    J Cell Sci; 2012 Feb 15; 125(Pt 4):1027-38. PubMed ID: 22448038
    [Abstract] [Full Text] [Related]

  • 2. Prothymosin-alpha mediates nuclear import of the INrf2/Cul3 Rbx1 complex to degrade nuclear Nrf2.
    Niture SK, Jaiswal AK.
    J Biol Chem; 2009 May 15; 284(20):13856-13868. PubMed ID: 19279002
    [Abstract] [Full Text] [Related]

  • 3. Nrf2 signaling and cell survival.
    Niture SK, Kaspar JW, Shen J, Jaiswal AK.
    Toxicol Appl Pharmacol; 2010 Apr 01; 244(1):37-42. PubMed ID: 19538984
    [Abstract] [Full Text] [Related]

  • 4. An autoregulatory loop between Nrf2 and Cul3-Rbx1 controls their cellular abundance.
    Kaspar JW, Jaiswal AK.
    J Biol Chem; 2010 Jul 09; 285(28):21349-58. PubMed ID: 20452971
    [Abstract] [Full Text] [Related]

  • 5. Hsp90 interaction with INrf2(Keap1) mediates stress-induced Nrf2 activation.
    Niture SK, Jaiswal AK.
    J Biol Chem; 2010 Nov 19; 285(47):36865-75. PubMed ID: 20864537
    [Abstract] [Full Text] [Related]

  • 6. Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis.
    Niture SK, Jaiswal AK.
    J Biol Chem; 2011 Dec 30; 286(52):44542-56. PubMed ID: 22072718
    [Abstract] [Full Text] [Related]

  • 7. Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression.
    Kaspar JW, Jaiswal AK.
    FASEB J; 2011 Mar 30; 25(3):1076-87. PubMed ID: 21097520
    [Abstract] [Full Text] [Related]

  • 8. Regulation of Nrf2-an update.
    Niture SK, Khatri R, Jaiswal AK.
    Free Radic Biol Med; 2014 Jan 30; 66():36-44. PubMed ID: 23434765
    [Abstract] [Full Text] [Related]

  • 9. INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis.
    Niture SK, Jaiswal AK.
    Cell Death Differ; 2011 Mar 30; 18(3):439-51. PubMed ID: 20865015
    [Abstract] [Full Text] [Related]

  • 10. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.
    Sun Z, Zhang S, Chan JY, Zhang DD.
    Mol Cell Biol; 2007 Sep 30; 27(18):6334-49. PubMed ID: 17636022
    [Abstract] [Full Text] [Related]

  • 11. Oncogene PKCε controls INrf2-Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2.
    Niture SK, Gnatt A, Jaiswal AK.
    J Cell Sci; 2013 Dec 15; 126(Pt 24):5657-69. PubMed ID: 24127568
    [Abstract] [Full Text] [Related]

  • 12. Antioxidant-induced modification of INrf2 cysteine 151 and PKC-delta-mediated phosphorylation of Nrf2 serine 40 are both required for stabilization and nuclear translocation of Nrf2 and increased drug resistance.
    Niture SK, Jain AK, Jaiswal AK.
    J Cell Sci; 2009 Dec 15; 122(Pt 24):4452-64. PubMed ID: 19920073
    [Abstract] [Full Text] [Related]

  • 13. An auto-regulatory loop between stress sensors INrf2 and Nrf2 controls their cellular abundance.
    Lee OH, Jain AK, Papusha V, Jaiswal AK.
    J Biol Chem; 2007 Dec 14; 282(50):36412-20. PubMed ID: 17925401
    [Abstract] [Full Text] [Related]

  • 14. Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.
    He X, Chen MG, Lin GX, Ma Q.
    J Biol Chem; 2006 Aug 18; 281(33):23620-31. PubMed ID: 16785233
    [Abstract] [Full Text] [Related]

  • 15. Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of Bach1 that allows Nrf2 to bind to the antioxidant response element and activate defensive gene expression.
    Kaspar JW, Jaiswal AK.
    J Biol Chem; 2010 Jan 01; 285(1):153-62. PubMed ID: 19897490
    [Abstract] [Full Text] [Related]

  • 16. Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer.
    Martinez VD, Vucic EA, Thu KL, Pikor LA, Hubaux R, Lam WL.
    Biomed Res Int; 2014 Jan 01; 2014():159459. PubMed ID: 25114896
    [Abstract] [Full Text] [Related]

  • 17. Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.
    Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT.
    Antioxid Redox Signal; 2010 Dec 01; 13(11):1713-48. PubMed ID: 20446772
    [Abstract] [Full Text] [Related]

  • 18. Prothymosin-α mediates nuclear import of the INrf2/Cul3·Rbx1 complex to degrade nuclear Nrf2.
    Niture SK, Jaiswal AK.
    J Biol Chem; 2016 Jan 15; 291(3):1199. PubMed ID: 26773126
    [No Abstract] [Full Text] [Related]

  • 19. Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.
    Eggler AL, Small E, Hannink M, Mesecar AD.
    Biochem J; 2009 Jul 29; 422(1):171-80. PubMed ID: 19489739
    [Abstract] [Full Text] [Related]

  • 20. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
    Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M.
    Mol Cell Biol; 2004 Dec 29; 24(24):10941-53. PubMed ID: 15572695
    [Abstract] [Full Text] [Related]

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