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Journal Abstract Search

1134 related items for PubMed ID: 22461615

  • 1. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
    Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA.
    Science; 2012 Mar 30; 335(6076):1638-43. PubMed ID: 22461615
    [Abstract] [Full Text] [Related]

  • 2. Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.
    Tang Y, Wallace M, Sanchez-Gurmaches J, Hsiao WY, Li H, Lee PL, Vernia S, Metallo CM, Guertin DA.
    Nat Commun; 2016 Apr 21; 7():11365. PubMed ID: 27098609
    [Abstract] [Full Text] [Related]

  • 3. mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells.
    Le Bacquer O, Queniat G, Gmyr V, Kerr-Conte J, Lefebvre B, Pattou F.
    J Endocrinol; 2013 Jan 21; 216(1):21-9. PubMed ID: 23092880
    [Abstract] [Full Text] [Related]

  • 4. Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan.
    Lamming DW, Mihaylova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM.
    Aging Cell; 2014 Oct 21; 13(5):911-7. PubMed ID: 25059582
    [Abstract] [Full Text] [Related]

  • 5. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.
    Kim SJ, DeStefano MA, Oh WJ, Wu CC, Vega-Cotto NM, Finlan M, Liu D, Su B, Jacinto E.
    Mol Cell; 2012 Dec 28; 48(6):875-87. PubMed ID: 23142081
    [Abstract] [Full Text] [Related]

  • 6. Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin.
    Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA.
    Mol Cell Biol; 2009 Mar 28; 29(6):1411-20. PubMed ID: 19114562
    [Abstract] [Full Text] [Related]

  • 7. Leucine facilitates the insulin-stimulated glucose uptake and insulin signaling in skeletal muscle cells: involving mTORC1 and mTORC2.
    Liu H, Liu R, Xiong Y, Li X, Wang X, Ma Y, Guo H, Hao L, Yao P, Liu L, Wang D, Yang X.
    Amino Acids; 2014 Aug 28; 46(8):1971-9. PubMed ID: 24806638
    [Abstract] [Full Text] [Related]

  • 8. Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice.
    Shum M, Bellmann K, St-Pierre P, Marette A.
    Diabetologia; 2016 Mar 28; 59(3):592-603. PubMed ID: 26733005
    [Abstract] [Full Text] [Related]

  • 9. The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts.
    Shu L, Houghton PJ.
    Mol Cell Biol; 2009 Sep 28; 29(17):4691-700. PubMed ID: 19564418
    [Abstract] [Full Text] [Related]

  • 10. Hypoxia Increases IGFBP-1 Phosphorylation Mediated by mTOR Inhibition.
    Damerill I, Biggar KK, Abu Shehab M, Li SS, Jansson T, Gupta MB.
    Mol Endocrinol; 2016 Feb 28; 30(2):201-16. PubMed ID: 26714229
    [Abstract] [Full Text] [Related]

  • 11. Enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by rapamycin-sensitive mTOR complex 1 inhibition.
    Kido K, Sase K, Yokokawa T, Fujita S.
    Sci Rep; 2020 May 22; 10(1):8509. PubMed ID: 32444657
    [Abstract] [Full Text] [Related]

  • 12. AMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle.
    Tandelilin AA, Hirase T, Hudoyo AW, Cheng J, Toyama K, Morisaki H, Morisaki T.
    BMC Endocr Disord; 2015 Mar 27; 15():11. PubMed ID: 25887856
    [Abstract] [Full Text] [Related]

  • 13. Down regulation of Peroxiredoxin-3 in 3T3-L1 adipocytes leads to oxidation of Rictor in the mammalian-target of rapamycin complex 2 (mTORC2).
    Olson DH, Burrill JS, Kuzmicic J, Hahn WS, Park JM, Kim DH, Bernlohr DA.
    Biochem Biophys Res Commun; 2017 Nov 25; 493(3):1311-1317. PubMed ID: 28986255
    [Abstract] [Full Text] [Related]

  • 14. CD40-induced signaling in human endothelial cells results in mTORC2- and Akt-dependent expression of vascular endothelial growth factor in vitro and in vivo.
    Dormond O, Contreras AG, Meijer E, Datta D, Flynn E, Pal S, Briscoe DM.
    J Immunol; 2008 Dec 01; 181(11):8088-95. PubMed ID: 19018001
    [Abstract] [Full Text] [Related]

  • 15. Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.
    Gulati N, Karsy M, Albert L, Murali R, Jhanwar-Uniyal M.
    Int J Oncol; 2009 Oct 01; 35(4):731-40. PubMed ID: 19724909
    [Abstract] [Full Text] [Related]

  • 16. mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.
    Julien LA, Carriere A, Moreau J, Roux PP.
    Mol Cell Biol; 2010 Feb 01; 30(4):908-21. PubMed ID: 19995915
    [Abstract] [Full Text] [Related]

  • 17. Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival.
    Wang Y, Mikhailova M, Bose S, Pan CX, deVere White RW, Ghosh PM.
    Oncogene; 2008 Nov 27; 27(56):7106-17. PubMed ID: 18776922
    [Abstract] [Full Text] [Related]

  • 18. Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage.
    Völkers M, Konstandin MH, Doroudgar S, Toko H, Quijada P, Din S, Joyo A, Ornelas L, Samse K, Thuerauf DJ, Gude N, Glembotski CC, Sussman MA.
    Circulation; 2013 Nov 05; 128(19):2132-44. PubMed ID: 24008870
    [Abstract] [Full Text] [Related]

  • 19. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.
    Wang RH, Kim HS, Xiao C, Xu X, Gavrilova O, Deng CX.
    J Clin Invest; 2011 Nov 05; 121(11):4477-90. PubMed ID: 21965330
    [Abstract] [Full Text] [Related]

  • 20. Effects of rapamycin on growth hormone receptor knockout mice.
    Fang Y, Hill CM, Darcy J, Reyes-Ordoñez A, Arauz E, McFadden S, Zhang C, Osland J, Gao J, Zhang T, Frank SJ, Javors MA, Yuan R, Kopchick JJ, Sun LY, Chen J, Bartke A.
    Proc Natl Acad Sci U S A; 2018 Feb 13; 115(7):E1495-E1503. PubMed ID: 29378959
    [Abstract] [Full Text] [Related]

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