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Journal Abstract Search

434 related items for PubMed ID: 22508546

  • 1. Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect.
    Quach P, Gutierrez E, Basha MT, Kalinowski DS, Sharpe PC, Lovejoy DB, Bernhardt PV, Jansson PJ, Richardson DR.
    Mol Pharmacol; 2012 Jul; 82(1):105-14. PubMed ID: 22508546
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  • 3. Kinetico-mechanistic studies on methemoglobin generation by biologically active thiosemicarbazone iron(III) complexes.
    Basha MT, Bordini J, Richardson DR, Martinez M, Bernhardt PV.
    J Inorg Biochem; 2016 Sep; 162():326-333. PubMed ID: 27079328
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  • 8. The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.
    Gutierrez E, Richardson DR, Jansson PJ.
    J Biol Chem; 2014 Nov 28; 289(48):33568-89. PubMed ID: 25301941
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  • 9. Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents.
    Sestak V, Stariat J, Cermanova J, Potuckova E, Chladek J, Roh J, Bures J, Jansova H, Prusa P, Sterba M, Micuda S, Simunek T, Kalinowski DS, Richardson DR, Kovarikova P.
    Oncotarget; 2015 Dec 15; 6(40):42411-28. PubMed ID: 26623727
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  • 10. Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: cellular iron chelation mediating cytotoxic activity.
    Opletalová V, Kalinowski DS, Vejsová M, Kunes J, Pour M, Jampílek J, Buchta V, Richardson DR.
    Chem Res Toxicol; 2008 Sep 15; 21(9):1878-89. PubMed ID: 18698850
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  • 11. Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (STAT3) pathway: inhibition of constitutive and interleukin 6-induced activation by iron depletion.
    Lui GY, Kovacevic Z, V Menezes S, Kalinowski DS, Merlot AM, Sahni S, Richardson DR.
    Mol Pharmacol; 2015 Sep 15; 87(3):543-60. PubMed ID: 25561562
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  • 16. Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.
    Lovejoy DB, Sharp DM, Seebacher N, Obeidy P, Prichard T, Stefani C, Basha MT, Sharpe PC, Jansson PJ, Kalinowski DS, Bernhardt PV, Richardson DR.
    J Med Chem; 2012 Aug 23; 55(16):7230-44. PubMed ID: 22861499
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  • 17. Synthesis and biological evaluation of 2-benzoylpyridine thiosemicarbazones in a dimeric system: structure-activity relationship studies on their anti-proliferative and iron chelation efficacy.
    Lukmantara AY, Kalinowski DS, Kumar N, Richardson DR.
    J Inorg Biochem; 2014 Dec 23; 141():43-54. PubMed ID: 25217717
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  • 18. Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.
    Ishiguro K, Lin ZP, Penketh PG, Shyam K, Zhu R, Baumann RP, Zhu YL, Sartorelli AC, Rutherford TJ, Ratner ES.
    Biochem Pharmacol; 2014 Oct 01; 91(3):312-22. PubMed ID: 25130544
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  • 19. Trypanotoxic activity of thiosemicarbazone iron chelators.
    Ellis S, Sexton DW, Steverding D.
    Exp Parasitol; 2015 Mar 01; 150():7-12. PubMed ID: 25595343
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  • 20. Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).
    Gutierrez EM, Seebacher NA, Arzuman L, Kovacevic Z, Lane DJ, Richardson V, Merlot AM, Lok H, Kalinowski DS, Sahni S, Jansson PJ, Richardson DR.
    Biochim Biophys Acta; 2016 Jul 01; 1863(7 Pt A):1665-81. PubMed ID: 27102538
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