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Journal Abstract Search

138 related items for PubMed ID: 22521736

  • 1. Supporting role of lysine 13 and glutamate 16 in the acid-base mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
    Kumar VP, West AH, Cook PF.
    Arch Biochem Biophys; 2012 Jun 01; 522(1):57-61. PubMed ID: 22521736
    [Abstract] [Full Text] [Related]

  • 2. Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae.
    Kumar VP, Thomas LM, Bobyk KD, Andi B, Cook PF, West AH.
    Biochemistry; 2012 Jan 31; 51(4):857-66. PubMed ID: 22243403
    [Abstract] [Full Text] [Related]

  • 3. The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH.
    Bobyk KD, Kim SG, Kumar VP, Kim SK, West AH, Cook PF.
    Arch Biochem Biophys; 2011 Sep 15; 513(2):71-80. PubMed ID: 21798231
    [Abstract] [Full Text] [Related]

  • 4. A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae.
    Xu H, Alguindigue SS, West AH, Cook PF.
    Biochemistry; 2007 Jan 23; 46(3):871-82. PubMed ID: 17223709
    [Abstract] [Full Text] [Related]

  • 5. Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae.
    Xu H, West AH, Cook PF.
    Biochemistry; 2006 Oct 03; 45(39):12156-66. PubMed ID: 17002315
    [Abstract] [Full Text] [Related]

  • 6. Glutamates 78 and 122 in the active site of saccharopine dehydrogenase contribute to reactant binding and modulate the basicity of the acid-base catalysts.
    Ekanayake DK, Andi B, Bobyk KD, West AH, Cook PF.
    J Biol Chem; 2010 Jul 02; 285(27):20756-68. PubMed ID: 20427272
    [Abstract] [Full Text] [Related]

  • 7. Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae.
    Vashishtha AK, West AH, Cook PF.
    Biochemistry; 2009 Jun 30; 48(25):5899-907. PubMed ID: 19449898
    [Abstract] [Full Text] [Related]

  • 8.
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  • 9. Crystal structures of ligand-bound saccharopine dehydrogenase from Saccharomyces cerevisiae.
    Andi B, Xu H, Cook PF, West AH.
    Biochemistry; 2007 Nov 06; 46(44):12512-21. PubMed ID: 17939687
    [Abstract] [Full Text] [Related]

  • 10. Structural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiae.
    Burk DL, Hwang J, Kwok E, Marrone L, Goodfellow V, Dmitrienko GI, Berghuis AM.
    J Mol Biol; 2007 Oct 26; 373(3):745-54. PubMed ID: 17854830
    [Abstract] [Full Text] [Related]

  • 11. Probing the chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae using site-directed mutagenesis.
    Vashishtha AK, West AH, Cook PF.
    Arch Biochem Biophys; 2015 Oct 15; 584():98-106. PubMed ID: 26342457
    [Abstract] [Full Text] [Related]

  • 12. Overall kinetic mechanism of saccharopine dehydrogenase (L-glutamate forming) from Saccharomyces cerevisiae.
    Vashishtha AK, West AH, Cook PF.
    Biochemistry; 2008 May 13; 47(19):5417-23. PubMed ID: 18416559
    [Abstract] [Full Text] [Related]

  • 13.
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  • 14. Evidence for a catalytic dyad in the active site of homocitrate synthase from Saccharomyces cerevisiae.
    Qian J, Khandogin J, West AH, Cook PF.
    Biochemistry; 2008 Jul 01; 47(26):6851-8. PubMed ID: 18533686
    [Abstract] [Full Text] [Related]

  • 15. Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae.
    Lin Y, West AH, Cook PF.
    Biochemistry; 2009 Aug 04; 48(30):7305-12. PubMed ID: 19530703
    [Abstract] [Full Text] [Related]

  • 16. Acid-base chemical mechanism of homocitrate synthase from Saccharomyces cerevisiae.
    Qian J, West AH, Cook PF.
    Biochemistry; 2006 Oct 03; 45(39):12136-43. PubMed ID: 17002313
    [Abstract] [Full Text] [Related]

  • 17. Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae.
    Xu H, West AH, Cook PF.
    Biochemistry; 2007 Jun 26; 46(25):7625-36. PubMed ID: 17542618
    [Abstract] [Full Text] [Related]

  • 18. Importance of the gamma-carboxyl group of glutamate-462 of the large alpha-subunit for the catalytic function and the stability of the multienzyme complex of fatty acid oxidation from Escherichia coli.
    He XY, Deng H, Yang SY.
    Biochemistry; 1997 Jan 07; 36(1):261-8. PubMed ID: 8993342
    [Abstract] [Full Text] [Related]

  • 19. Theoretical study on the proton shuttle mechanism of saccharopine dehydrogenase.
    Sheng X, Gao J, Liu Y, Liu C.
    J Mol Graph Model; 2013 Jul 07; 44():17-25. PubMed ID: 23732302
    [Abstract] [Full Text] [Related]

  • 20. Catalytic mechanism of scytalone dehydratase: site-directed mutagenisis, kinetic isotope effects, and alternate substrates.
    Basarab GS, Steffens JJ, Wawrzak Z, Schwartz RS, Lundqvist T, Jordan DB.
    Biochemistry; 1999 May 11; 38(19):6012-24. PubMed ID: 10320327
    [Abstract] [Full Text] [Related]

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