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Journal Abstract Search

230 related items for PubMed ID: 22522748

  • 1.
    ; . PubMed ID:
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  • 2. Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes.
    Hutzler JM, Yang YS, Albaugh D, Fullenwider CL, Schmenk J, Fisher MB.
    Drug Metab Dispos; 2012 Feb; 40(2):267-75. PubMed ID: 22031625
    [Abstract] [Full Text] [Related]

  • 3. Evaluation of Cytochrome P450 Selectivity for Hydralazine as an Aldehyde Oxidase Inhibitor for Reaction Phenotyping.
    Yang X, Johnson N, Di L.
    J Pharm Sci; 2019 Apr; 108(4):1627-1630. PubMed ID: 30448524
    [Abstract] [Full Text] [Related]

  • 4. Evaluation of Icotinib as a Potent and Selective Inhibitor of Aldehyde Oxidase for Reaction Phenotyping in Human Hepatocytes.
    Tang LWT, DaSilva E, Lapham K, Obach RS.
    Drug Metab Dispos; 2024 May 16; 52(6):565-573. PubMed ID: 38565303
    [Abstract] [Full Text] [Related]

  • 5. A quantitative approach to hepatic clearance prediction of metabolism by aldehyde oxidase using custom pooled hepatocytes.
    Akabane T, Gerst N, Masters JN, Tamura K.
    Xenobiotica; 2012 Sep 16; 42(9):863-71. PubMed ID: 22448773
    [Abstract] [Full Text] [Related]

  • 6. Aldehyde oxidase activity and inhibition in hepatocytes and cytosolic fractions from mouse, rat, monkey and human.
    Sahi J, Khan KK, Black CB.
    Drug Metab Lett; 2008 Aug 16; 2(3):176-83. PubMed ID: 19356090
    [Abstract] [Full Text] [Related]

  • 7. Case Study 11: Considerations for Enzyme Mapping Experiments-Interaction Between the Aldehyde Oxidase Inhibitor Hydralazine and Glutathione.
    Crouch RD, Beers JL, Jackson KD.
    Methods Mol Biol; 2021 Aug 16; 2342():809-823. PubMed ID: 34272718
    [Abstract] [Full Text] [Related]

  • 8. Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase.
    Lake BG, Ball SE, Kao J, Renwick AB, Price RJ, Scatina JA.
    Xenobiotica; 2002 Oct 16; 32(10):835-47. PubMed ID: 12419014
    [Abstract] [Full Text] [Related]

  • 9. Refinement of In Vitro Methods for Identification of Aldehyde Oxidase Substrates Reveals Metabolites of Kinase Inhibitors.
    Dick RA.
    Drug Metab Dispos; 2018 Jun 16; 46(6):846-859. PubMed ID: 29615437
    [Abstract] [Full Text] [Related]

  • 10. Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes.
    Tanoue C, Sugihara K, Uramaru N, Tayama Y, Watanabe Y, Horie T, Ohta S, Kitamura S.
    Xenobiotica; 2013 Nov 16; 43(11):956-62. PubMed ID: 23651075
    [Abstract] [Full Text] [Related]

  • 11. In Vitro Metabolism of 2-Methoxy-N-[3-[4-[3-methyl-4-[(6-methyl- 3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide (CP-724,714) by Aldehyde Oxidase and Predicting Its Percent Contribution Relative to CYP-Mediated Metabolism.
    Inoue K, Kikuchi K, Takahashi K, Hitaoka S, Kusano K, Komori T.
    Drug Metab Dispos; 2023 Aug 16; 51(8):962-969. PubMed ID: 37188528
    [Abstract] [Full Text] [Related]

  • 12. Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions.
    Nirogi R, Kandikere V, Palacharla RC, Bhyrapuneni G, Kanamarlapudi VB, Ponnamaneni RK, Manoharan AK.
    Xenobiotica; 2014 Mar 16; 44(3):197-204. PubMed ID: 24156774
    [Abstract] [Full Text] [Related]

  • 13. A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry.
    Crouch RD, Hutzler JM, Daniels JS.
    Xenobiotica; 2018 Mar 16; 48(3):219-231. PubMed ID: 28281401
    [Abstract] [Full Text] [Related]

  • 14. In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401.
    Zhang JW, Deng HB, Zhang CY, Dai JQ, Li Q, Zheng QG, Wan HX, Yu HP, He F, Xu YC, Zhao S, Zhang JYJ.
    Eur J Drug Metab Pharmacokinet; 2019 Oct 16; 44(5):669-680. PubMed ID: 31030415
    [Abstract] [Full Text] [Related]

  • 15. Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.
    Crouch RD, Morrison RD, Byers FW, Lindsley CW, Emmitte KA, Daniels JS.
    Drug Metab Dispos; 2016 Aug 16; 44(8):1296-303. PubMed ID: 26936972
    [Abstract] [Full Text] [Related]

  • 16. Aldehyde oxidase activity in donor-matched fresh and cryopreserved human hepatocytes and assessment of variability in 75 donors.
    Hutzler JM, Yang YS, Brown C, Heyward S, Moeller T.
    Drug Metab Dispos; 2014 Jun 16; 42(6):1090-7. PubMed ID: 24713130
    [Abstract] [Full Text] [Related]

  • 17. Challenges and Opportunities for In Vitro-In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation.
    Izat N, Bolleddula J, Abbasi A, Cheruzel L, Jones RS, Moss D, Ortega-Muro F, Parmentier Y, Peterkin VC, Tian DD, Venkatakrishnan K, Zientek MA, Barber J, Houston JB, Galetin A, Scotcher D.
    Drug Metab Dispos; 2023 Dec 16; 51(12):1591-1606. PubMed ID: 37751998
    [Abstract] [Full Text] [Related]

  • 18. Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes.
    Sanoh S, Nozaki K, Murai H, Terashita S, Teramura T, Ohta S.
    Drug Metab Dispos; 2012 Jan 16; 40(1):76-82. PubMed ID: 21984595
    [Abstract] [Full Text] [Related]

  • 19. Monoamine oxidase B oxidizes a novel multikinase inhibitor KW-2449 to its iminium ion and aldehyde oxidase further converts it to the oxo-piperazine form in human.
    Hosogi J, Ohashi R, Maeda H, Tashiro S, Fuse E, Yamamoto Y, Kuwabara T.
    Drug Metab Pharmacokinet; 2017 Oct 16; 32(5):255-264. PubMed ID: 28751116
    [Abstract] [Full Text] [Related]

  • 20. Cynomolgus monkey as a surrogate for human aldehyde oxidase metabolism of the EGFR inhibitor BIBX1382.
    Hutzler JM, Cerny MA, Yang YS, Asher C, Wong D, Frederick K, Gilpin K.
    Drug Metab Dispos; 2014 Oct 16; 42(10):1751-60. PubMed ID: 25035284
    [Abstract] [Full Text] [Related]

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