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136 related items for PubMed ID: 22530946

  • 1. Intramolecular free-radical cyclization reactions on pentose sugars for the synthesis of carba-LNA and carba-ENA and the application of their modified oligonucleotides as potential RNA targeted therapeutics.
    Zhou C, Chattopadhyaya J.
    Chem Rev; 2012 Jul 11; 112(7):3808-32. PubMed ID: 22530946
    [No Abstract] [Full Text] [Related]

  • 2. Free-radical ring closure to conformationally locked α-L-carba-LNAs and synthesis of their oligos: nuclease stability, target RNA specificity, and elicitation of RNase H.
    Li Q, Yuan F, Zhou C, Plashkevych O, Chattopadhyaya J.
    J Org Chem; 2010 Sep 17; 75(18):6122-40. PubMed ID: 20738147
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  • 3. Carba-LNA-5MeC/A/G/T modified oligos show nucleobase-specific modulation of 3'-exonuclease activity, thermodynamic stability, RNA selectivity, and RNase H elicitation: synthesis and biochemistry.
    Upadhayaya R, Deshpande SG, Li Q, Kardile RA, Sayyed AY, Kshirsagar EK, Salunke RV, Dixit SS, Zhou C, Földesi A, Chattopadhyaya J.
    J Org Chem; 2011 Jun 03; 76(11):4408-31. PubMed ID: 21500818
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  • 4. Synthesis of conformationally locked Carba-LNAs through intramolecular free-radical addition to C=N. Electrostatic and steric implication of the carba-LNA substituents in the modified oligos for nuclease and thermodynamic stabilities.
    Xu J, Liu Y, Dupouy C, Chattopadhyaya J.
    J Org Chem; 2009 Sep 04; 74(17):6534-54. PubMed ID: 19670835
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  • 9. Carbocyclic C-C Bond Formation: Intramolecular Radical Ring Closure to Yield Diastereomerically Pure (7'S-Me- or 7'R-Me-) Carba-LNA Nucleotide Analogs.
    Plashkevych O, Upadhayaya RS, Chattopadhyaya J.
    Curr Protoc Nucleic Acid Chem; 2017 Jun 19; 69():4.74.1-4.74.42. PubMed ID: 28628208
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  • 11. Why Carba-LNA-modified oligonucleotides show considerably improved 3'-exonuclease stability compared to that of the LNA modified or the native counterparts: A Michaelis-Menten kinetic analysis.
    Zhou C, Chattopadhyaya J.
    J Org Chem; 2010 Apr 02; 75(7):2341-9. PubMed ID: 20225808
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  • 16. Taming the free radical shrew - learning to control homolytic reactions at higher heteroatoms.
    Schiesser CH.
    Chem Commun (Camb); 2006 Oct 21; (39):4055-65. PubMed ID: 17024249
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  • 18. Synthesis and evaluation of alpha-LNA.
    Christensen NK, Dalskov JK, Nielsen P.
    Nucleosides Nucleotides Nucleic Acids; 2001 Oct 21; 20(4-7):825-8. PubMed ID: 11563124
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  • 19. Hybrid lipid oligonucleotide conjugates: synthesis, self-assemblies and biomedical applications.
    Patwa A, Gissot A, Bestel I, Barthélémy P.
    Chem Soc Rev; 2011 Dec 21; 40(12):5844-54. PubMed ID: 21611637
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  • 20. Molecular structure of the core-modified siRNA duplexes containing diastereomeric pair of [C6'(R)-OH]- versus [C6'(S)-OH]-carba-LNAs suggests a model for RNAi action.
    Plashkevych O, Chattopadhyaya J.
    Nucleosides Nucleotides Nucleic Acids; 2011 Nov 21; 30(11):815-25. PubMed ID: 22060548
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