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Journal Abstract Search

151 related items for PubMed ID: 2254317

  • 1. The mechanism of cysteine conjugate cytotoxicity in renal epithelial cells. Covalent binding leads to thiol depletion and lipid peroxidation.
    Chen Q, Jones TW, Brown PC, Stevens JL.
    J Biol Chem; 1990 Dec 15; 265(35):21603-11. PubMed ID: 2254317
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of iodoacetamide and t-butylhydroperoxide toxicity in LLC-PK1 cells by antioxidants: a role for lipid peroxidation in alkylation induced cytotoxicity.
    Chen Q, Stevens JL.
    Arch Biochem Biophys; 1991 Feb 01; 284(2):422-30. PubMed ID: 1989526
    [Abstract] [Full Text] [Related]

  • 3. Role of lipid peroxidation in renal proximal tubule cell death induced by haloalkene cysteine conjugates.
    Groves CE, Lock EA, Schnellmann RG.
    Toxicol Appl Pharmacol; 1991 Jan 01; 107(1):54-62. PubMed ID: 1987660
    [Abstract] [Full Text] [Related]

  • 4. Early cellular events couple covalent binding of reactive metabolites to cell killing by nephrotoxic cysteine conjugates.
    Chen Q, Jones TW, Stevens JL.
    J Cell Physiol; 1994 Nov 01; 161(2):293-302. PubMed ID: 7525611
    [Abstract] [Full Text] [Related]

  • 5. Inhibition of S-(1,2-dichlorovinyl)-L-cysteine-induced lipid peroxidation by antioxidants in rabbit renal cortical slices: dissociation of lipid peroxidation and toxicity.
    Davis JW, Petry TW.
    J Biochem Toxicol; 1994 Jun 01; 9(3):121-30. PubMed ID: 7983677
    [Abstract] [Full Text] [Related]

  • 6. Activation of the growth arrest and DNA damage-inducible gene gadd 153 by nephrotoxic cysteine conjugates and dithiothreitol.
    Chen Q, Yu K, Holbrook NJ, Stevens JL.
    J Biol Chem; 1992 Apr 25; 267(12):8207-12. PubMed ID: 1569075
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of succinate:ubiquinone reductase and decrease of ubiquinol in nephrotoxic cysteine S-conjugate-induced oxidative cell injury.
    van de Water B, Zoeteweij JP, de Bont HJ, Nagelkerke JF.
    Mol Pharmacol; 1995 Nov 25; 48(5):928-37. PubMed ID: 7476924
    [Abstract] [Full Text] [Related]

  • 8. Renal cysteine conjugate beta-lyase-mediated toxicity studied with primary cultures of human proximal tubular cells.
    Chen JC, Stevens JL, Trifillis AL, Jones TW.
    Toxicol Appl Pharmacol; 1990 May 25; 103(3):463-73. PubMed ID: 2339419
    [Abstract] [Full Text] [Related]

  • 9. Roles of cysteine conjugate beta-lyase and S-oxidase in nephrotoxicity: studies with S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine sulfoxide.
    Lash LH, Sausen PJ, Duescher RJ, Cooley AJ, Elfarra AA.
    J Pharmacol Exp Ther; 1994 Apr 25; 269(1):374-83. PubMed ID: 8169843
    [Abstract] [Full Text] [Related]

  • 10. Quantitation of multiple pathways for the metabolism of nephrotoxic cysteine conjugates using selective inhibitors of L-alpha-hydroxy acid oxidase (L-amino acid oxidase) and cysteine conjugate beta-lyase.
    Stevens JL, Hatzinger PB, Hayden PJ.
    Drug Metab Dispos; 1989 Apr 25; 17(3):297-303. PubMed ID: 2568912
    [Abstract] [Full Text] [Related]

  • 11. Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine.
    van de Water B, Zoeteweij JP, de Bont HJ, Mulder GJ, Nagelkerke JF.
    J Biol Chem; 1994 May 20; 269(20):14546-52. PubMed ID: 8182062
    [Abstract] [Full Text] [Related]

  • 12. Alkylation-induced oxidative cell injury of renal proximal tubular cells: involvement of glutathione redox-cycle inhibition.
    van de Water B, Zoeteweij JP, Nagelkerke JF.
    Arch Biochem Biophys; 1996 Mar 01; 327(1):71-80. PubMed ID: 8615698
    [Abstract] [Full Text] [Related]

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  • 14. Regulation of the cellular stress response by reactive electrophiles. The role of covalent binding and cellular thiols in transcriptional activation of the 70-kilodalton heat shock protein gene by nephrotoxic cysteine conjugates.
    Chen Q, Yu K, Stevens JL.
    J Biol Chem; 1992 Dec 05; 267(34):24322-7. PubMed ID: 1447182
    [Abstract] [Full Text] [Related]

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  • 16. Differential cellular effects in the toxicity of haloalkene and haloalkane cysteine conjugates to rabbit renal proximal tubules.
    Groves CE, Hayden PJ, Lock EA, Schnellmann RG.
    J Biochem Toxicol; 1993 Mar 05; 8(1):49-56. PubMed ID: 8492303
    [Abstract] [Full Text] [Related]

  • 17. The role of glutathione conjugate metabolism and cysteine conjugate beta-lyase in the mechanism of S-cysteine conjugate toxicity in LLC-PK1 cells.
    Stevens J, Hayden P, Taylor G.
    J Biol Chem; 1986 Mar 05; 261(7):3325-32. PubMed ID: 3753976
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  • 19. Cellular injury induced by oxidative stress is mediated through lysosomal damage.
    Ollinger K, Brunk UT.
    Free Radic Biol Med; 1995 Nov 05; 19(5):565-74. PubMed ID: 8529915
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