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548 related items for PubMed ID: 22561361

  • 1. Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.
    Said TH, Wilson LD, Jeyaraj D, Fossa AA, Rosenbaum DS.
    J Cardiovasc Pharmacol; 2012 Aug; 60(2):165-71. PubMed ID: 22561361
    [Abstract] [Full Text] [Related]

  • 2. Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil.
    Aiba T, Shimizu W, Inagaki M, Noda T, Miyoshi S, Ding WG, Zankov DP, Toyoda F, Matsuura H, Horie M, Sunagawa K.
    J Am Coll Cardiol; 2005 Jan 18; 45(2):300-7. PubMed ID: 15653031
    [Abstract] [Full Text] [Related]

  • 3. Cisapride-induced transmural dispersion of repolarization and torsade de pointes in the canine left ventricular wedge preparation during epicardial stimulation.
    Di Diego JM, Belardinelli L, Antzelevitch C.
    Circulation; 2003 Aug 26; 108(8):1027-33. PubMed ID: 12912819
    [Abstract] [Full Text] [Related]

  • 4. Nonclinical proarrhythmia models: predicting Torsades de Pointes.
    Lawrence CL, Pollard CE, Hammond TG, Valentin JP.
    J Pharmacol Toxicol Methods; 2005 Aug 26; 52(1):46-59. PubMed ID: 15975832
    [Abstract] [Full Text] [Related]

  • 5. Epicardial activation of left ventricular wall prolongs QT interval and transmural dispersion of repolarization: implications for biventricular pacing.
    Fish JM, Di Diego JM, Nesterenko V, Antzelevitch C.
    Circulation; 2004 May 04; 109(17):2136-42. PubMed ID: 15078801
    [Abstract] [Full Text] [Related]

  • 6. Cellular and ionic mechanisms underlying erythromycin-induced long QT intervals and torsade de pointes.
    Antzelevitch C, Sun ZQ, Zhang ZQ, Yan GX.
    J Am Coll Cardiol; 1996 Dec 04; 28(7):1836-48. PubMed ID: 8962574
    [Abstract] [Full Text] [Related]

  • 7. Proarrhythmia as a class effect of quinolones: increased dispersion of repolarization and triangulation of action potential predict torsades de pointes.
    Milberg P, Hilker E, Ramtin S, Cakir Y, Stypmann J, Engelen MA, Mönnig G, Osada N, Breithardt G, Haverkamp W, Eckardt L.
    J Cardiovasc Electrophysiol; 2007 Jun 04; 18(6):647-54. PubMed ID: 17388913
    [Abstract] [Full Text] [Related]

  • 8. Drug-induced QT prolongation and proarrhythmia: an inevitable link?
    Ahmad K, Dorian P.
    Europace; 2007 Sep 04; 9 Suppl 4():iv16-22. PubMed ID: 17766320
    [Abstract] [Full Text] [Related]

  • 9. A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs).
    Lu HR, Yan GX, Gallacher DJ.
    J Pharmacol Toxicol Methods; 2013 Sep 04; 68(2):250-259. PubMed ID: 23337247
    [Abstract] [Full Text] [Related]

  • 10. Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome: effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes.
    Shimizu W, Antzelevitch C.
    Circulation; 1998 Nov 24; 98(21):2314-22. PubMed ID: 9826320
    [Abstract] [Full Text] [Related]

  • 11. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit.
    Jacobson I, Carlsson L, Duker G.
    J Pharmacol Toxicol Methods; 2011 Nov 24; 63(1):40-6. PubMed ID: 20451633
    [Abstract] [Full Text] [Related]

  • 12. Sodium pentobarbital reduces transmural dispersion of repolarization and prevents torsades de Pointes in models of acquired and congenital long QT syndrome.
    Shimizu W, McMahon B, Antzelevitch C.
    J Cardiovasc Electrophysiol; 1999 Feb 24; 10(2):154-64. PubMed ID: 10090218
    [Abstract] [Full Text] [Related]

  • 13. Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice.
    Farkas AS, Nattel S.
    Drugs; 2010 Mar 26; 70(5):573-603. PubMed ID: 20329805
    [Abstract] [Full Text] [Related]

  • 14. Drug-induced QT-interval prolongation and proarrhythmic risk in the treatment of atrial arrhythmias.
    Shantsila E, Watson T, Lip GY.
    Europace; 2007 Sep 26; 9 Suppl 4():iv37-44. PubMed ID: 17766322
    [Abstract] [Full Text] [Related]

  • 15. Availability of human induced pluripotent stem cell-derived cardiomyocytes in assessment of drug potential for QT prolongation.
    Nozaki Y, Honda Y, Tsujimoto S, Watanabe H, Kunimatsu T, Funabashi H.
    Toxicol Appl Pharmacol; 2014 Jul 01; 278(1):72-7. PubMed ID: 24742750
    [Abstract] [Full Text] [Related]

  • 16. In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation.
    Lu HR, Vlaminckx E, Van de Water A, Rohrbacher J, Hermans A, Gallacher DJ.
    Eur J Pharmacol; 2006 Dec 28; 553(1-3):229-39. PubMed ID: 17054943
    [Abstract] [Full Text] [Related]

  • 17. TRIad: foundation for proarrhythmia (triangulation, reverse use dependence and instability).
    Hondeghem LM.
    Novartis Found Symp; 2005 Dec 28; 266():235-44; discussion 244-50. PubMed ID: 16050272
    [Abstract] [Full Text] [Related]

  • 18. Divergent proarrhythmic potential of macrolide antibiotics despite similar QT prolongation: fast phase 3 repolarization prevents early afterdepolarizations and torsade de pointes.
    Milberg P, Eckardt L, Bruns HJ, Biertz J, Ramtin S, Reinsch N, Fleischer D, Kirchhof P, Fabritz L, Breithardt G, Haverkamp W.
    J Pharmacol Exp Ther; 2002 Oct 28; 303(1):218-25. PubMed ID: 12235254
    [Abstract] [Full Text] [Related]

  • 19. Utility of hERG assays as surrogate markers of delayed cardiac repolarization and QT safety.
    Gintant GA, Su Z, Martin RL, Cox BF.
    Toxicol Pathol; 2006 Oct 28; 34(1):81-90. PubMed ID: 16507548
    [Abstract] [Full Text] [Related]

  • 20. Thorough QT/QTc not so thorough: removes torsadogenic predictors from the T-wave, incriminates safe drugs, and misses profibrillatory drugs.
    Hondeghem LM.
    J Cardiovasc Electrophysiol; 2006 Mar 28; 17(3):337-40. PubMed ID: 16643415
    [Abstract] [Full Text] [Related]

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