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134 related items for PubMed ID: 22579651

  • 1. Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models.
    Chiacchiera F, Grossi V, Cappellari M, Peserico A, Simonatto M, Germani A, Russo S, Moyer MP, Resta N, Murzilli S, Simone C.
    Cancer Lett; 2012 Nov 01; 324(1):98-108. PubMed ID: 22579651
    [Abstract] [Full Text] [Related]

  • 2. P38 MAP kinase functions as a switch in MS-275-induced reactive oxygen species-dependent autophagy and apoptosis in human colon cancer cells.
    Zhan Y, Gong K, Chen C, Wang H, Li W.
    Free Radic Biol Med; 2012 Aug 01; 53(3):532-43. PubMed ID: 22634147
    [Abstract] [Full Text] [Related]

  • 3. p38alpha blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1alpha- to FoxO-dependent transcription.
    Chiacchiera F, Matrone A, Ferrari E, Ingravallo G, Lo Sasso G, Murzilli S, Petruzzelli M, Salvatore L, Moschetta A, Simone C.
    Cell Death Differ; 2009 Sep 01; 16(9):1203-14. PubMed ID: 19343039
    [Abstract] [Full Text] [Related]

  • 4. Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A.
    Germani A, Matrone A, Grossi V, Peserico A, Sanese P, Liuzzi M, Palermo R, Murzilli S, Campese AF, Ingravallo G, Canettieri G, Tezil T, Simone C.
    Cancer Lett; 2014 Mar 01; 344(1):110-118. PubMed ID: 24215867
    [Abstract] [Full Text] [Related]

  • 5. Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells.
    Warfel NA, Lepper ER, Zhang C, Figg WD, Dennis PA.
    Clin Cancer Res; 2006 Jun 01; 12(11 Pt 1):3502-9. PubMed ID: 16740776
    [Abstract] [Full Text] [Related]

  • 6. p38 MAPK regulates phosphorylation of Bad via PP2A-dependent suppression of the MEK1/2-ERK1/2 survival pathway in TNF-alpha induced endothelial apoptosis.
    Grethe S, Pörn-Ares MI.
    Cell Signal; 2006 Apr 01; 18(4):531-40. PubMed ID: 15972258
    [Abstract] [Full Text] [Related]

  • 7. Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors.
    Sheppard KE, Cullinane C, Hannan KM, Wall M, Chan J, Barber F, Foo J, Cameron D, Neilsen A, Ng P, Ellul J, Kleinschmidt M, Kinross KM, Bowtell DD, Christensen JG, Hicks RJ, Johnstone RW, McArthur GA, Hannan RD, Phillips WA, Pearson RB.
    Eur J Cancer; 2013 Dec 01; 49(18):3936-44. PubMed ID: 24011934
    [Abstract] [Full Text] [Related]

  • 8. Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer.
    Pitts TM, Newton TP, Bradshaw-Pierce EL, Addison R, Arcaroli JJ, Klauck PJ, Bagby SM, Hyatt SL, Purkey A, Tentler JJ, Tan AC, Messersmith WA, Eckhardt SG, Leong S.
    PLoS One; 2014 Dec 01; 9(11):e113037. PubMed ID: 25401499
    [Abstract] [Full Text] [Related]

  • 9. Preclinical analysis of the anti-tumor and anti-metastatic effects of Raf265 on colon cancer cells and CD26(+) cancer stem cells in colorectal carcinoma.
    Chow AK, Cheng NS, Lam CS, Ng L, Wong SK, Wan TM, Man JH, Cheung AH, Yau TC, Poon JT, Law WL, Pang RW.
    Mol Cancer; 2015 Apr 11; 14():80. PubMed ID: 25884645
    [Abstract] [Full Text] [Related]

  • 10. Targeting cap-dependent translation to inhibit Chikungunya virus replication: selectivity of p38 MAPK inhibitors to virus-infected cells due to autophagy-mediated down regulation of phospho-ERK.
    Mudaliar P, Pradeep P, Abraham R, Sreekumar E.
    J Gen Virol; 2021 Jul 11; 102(7):. PubMed ID: 34328830
    [Abstract] [Full Text] [Related]

  • 11. Inhibition of TRAIL-induced apoptosis by IL-8 is mediated by the p38-MAPK pathway in OVCAR3 cells.
    Abdollahi T, Robertson NM, Abdollahi A, Litwack G.
    Apoptosis; 2005 Dec 11; 10(6):1383-93. PubMed ID: 16215677
    [Abstract] [Full Text] [Related]

  • 12. Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.
    van Houdt WJ, de Bruijn MT, Emmink BL, Raats D, Hoogwater FJ, Borel Rinkes IH, Kranenburg O.
    Cell Oncol; 2010 Jan 01; 32(4):245-57. PubMed ID: 20413844
    [Abstract] [Full Text] [Related]

  • 13. Involvement of histone H3 phosphorylation through p38 MAPK pathway activation in casticin-induced cytocidal effects against the human promyelocytic cell line HL-60.
    Kikuchi H, Yuan B, Yuhara E, Takagi N, Toyoda H.
    Int J Oncol; 2013 Dec 01; 43(6):2046-56. PubMed ID: 24064676
    [Abstract] [Full Text] [Related]

  • 14. Inhibition of mitogen-activated protein kinase kinase enhances apoptosis induced by arsenic trioxide in human breast cancer MCF-7 cells.
    Ye J, Li A, Liu Q, Wang X, Zhou J.
    Clin Exp Pharmacol Physiol; 2005 Dec 01; 32(12):1042-8. PubMed ID: 16445569
    [Abstract] [Full Text] [Related]

  • 15. Oncogenic KRAS-associated gene signature defines co-targeting of CDK4/6 and MEK as a viable therapeutic strategy in colorectal cancer.
    Pek M, Yatim SMJM, Chen Y, Li J, Gong M, Jiang X, Zhang F, Zheng J, Wu X, Yu Q.
    Oncogene; 2017 Aug 31; 36(35):4975-4986. PubMed ID: 28459468
    [Abstract] [Full Text] [Related]

  • 16. p38 and ERK MAP kinase mediates iron chelator-induced apoptosis and -suppressed differentiation of immortalized and malignant human oral keratinocytes.
    Lee SK, Jang HJ, Lee HJ, Lee J, Jeon BH, Jun CD, Lee SK, Kim EC.
    Life Sci; 2006 Sep 05; 79(15):1419-27. PubMed ID: 16697418
    [Abstract] [Full Text] [Related]

  • 17. Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models.
    Lee MS, Helms TL, Feng N, Gay J, Chang QE, Tian F, Wu JY, Toniatti C, Heffernan TP, Powis G, Kwong LN, Kopetz S.
    Oncotarget; 2016 Jun 28; 7(26):39595-39608. PubMed ID: 27167191
    [Abstract] [Full Text] [Related]

  • 18. Knockdown of linc-UFC1 suppresses proliferation and induces apoptosis of colorectal cancer.
    Yu T, Shan TD, Li JY, Huang CZ, Wang SY, Ouyang H, Lu XJ, Xu JH, Zhong W, Chen QK.
    Cell Death Dis; 2016 May 19; 7(5):e2228. PubMed ID: 27195675
    [Abstract] [Full Text] [Related]

  • 19. BRAF V600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells.
    Sueda T, Sakai D, Kawamoto K, Konno M, Nishida N, Koseki J, Colvin H, Takahashi H, Haraguchi N, Nishimura J, Hata T, Takemasa I, Mizushima T, Yamamoto H, Satoh T, Doki Y, Mori M, Ishii H.
    Sci Rep; 2016 Jan 11; 6():18949. PubMed ID: 26750638
    [Abstract] [Full Text] [Related]

  • 20. MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1.
    Azijli K, Yuvaraj S, van Roosmalen I, Flach K, Giovannetti E, Peters GJ, de Jong S, Kruyt FA.
    Apoptosis; 2013 Jul 11; 18(7):851-60. PubMed ID: 23456625
    [Abstract] [Full Text] [Related]

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