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Journal Abstract Search

209 related items for PubMed ID: 22581779

  • 1. Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.
    Ferguson CJ, Lenk GM, Jones JM, Grant AE, Winters JJ, Dowling JJ, Giger RJ, Meisler MH.
    Hum Mol Genet; 2012 Aug 15; 21(16):3525-34. PubMed ID: 22581779
    [Abstract] [Full Text] [Related]

  • 2. Congenital CNS hypomyelination in the Fig4 null mouse is rescued by neuronal expression of the PI(3,5)P(2) phosphatase Fig4.
    Winters JJ, Ferguson CJ, Lenk GM, Giger-Mateeva VI, Shrager P, Meisler MH, Giger RJ.
    J Neurosci; 2011 Nov 30; 31(48):17736-51. PubMed ID: 22131434
    [Abstract] [Full Text] [Related]

  • 3. Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene.
    Lenk GM, Frei CM, Miller AC, Wallen RC, Mironova YA, Giger RJ, Meisler MH.
    Hum Mol Genet; 2016 Jan 15; 25(2):340-7. PubMed ID: 26604144
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  • 4. Protective role of the lipid phosphatase Fig4 in the adult nervous system.
    Mironova YA, Lin JP, Kalinski AL, Huffman LD, Lenk GM, Havton LA, Meisler MH, Giger RJ.
    Hum Mol Genet; 2018 Jul 15; 27(14):2443-2453. PubMed ID: 29688489
    [Abstract] [Full Text] [Related]

  • 5. Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies.
    Vaccari I, Dina G, Tronchère H, Kaufman E, Chicanne G, Cerri F, Wrabetz L, Payrastre B, Quattrini A, Weisman LS, Meisler MH, Bolino A.
    PLoS Genet; 2011 Oct 15; 7(10):e1002319. PubMed ID: 22028665
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  • 6. Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J.
    Lenk GM, Ferguson CJ, Chow CY, Jin N, Jones JM, Grant AE, Zolov SN, Winters JJ, Giger RJ, Dowling JJ, Weisman LS, Meisler MH.
    PLoS Genet; 2011 Jun 15; 7(6):e1002104. PubMed ID: 21655088
    [Abstract] [Full Text] [Related]

  • 7. Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy.
    Vaccari I, Carbone A, Previtali SC, Mironova YA, Alberizzi V, Noseda R, Rivellini C, Bianchi F, Del Carro U, D'Antonio M, Lenk GM, Wrabetz L, Giger RJ, Meisler MH, Bolino A.
    Hum Mol Genet; 2015 Jan 15; 24(2):383-96. PubMed ID: 25187576
    [Abstract] [Full Text] [Related]

  • 8. The chloride antiporter CLCN7 is a modifier of lysosome dysfunction in FIG4 and VAC14 mutants.
    Cao X, Lenk GM, Mikusevic V, Mindell JA, Meisler MH.
    PLoS Genet; 2023 Jun 15; 19(6):e1010800. PubMed ID: 37363915
    [Abstract] [Full Text] [Related]

  • 9. FIG4 regulates lysosome membrane homeostasis independent of phosphatase function.
    Bharadwaj R, Cunningham KM, Zhang K, Lloyd TE.
    Hum Mol Genet; 2016 Feb 15; 25(4):681-92. PubMed ID: 26662798
    [Abstract] [Full Text] [Related]

  • 10. Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J.
    Chow CY, Zhang Y, Dowling JJ, Jin N, Adamska M, Shiga K, Szigeti K, Shy ME, Li J, Zhang X, Lupski JR, Weisman LS, Meisler MH.
    Nature; 2007 Jul 05; 448(7149):68-72. PubMed ID: 17572665
    [Abstract] [Full Text] [Related]

  • 11. Mouse models of PI(3,5)P2 deficiency with impaired lysosome function.
    Lenk GM, Meisler MH.
    Methods Enzymol; 2014 Jul 05; 534():245-60. PubMed ID: 24359958
    [Abstract] [Full Text] [Related]

  • 12. Chloroquine corrects enlarged lysosomes in FIG4 null cells and reduces neurodegeneration in Fig4 null mice.
    Lenk GM, Meisler MH.
    Mol Genet Metab; 2022 Dec 05; 137(4):382-387. PubMed ID: 36434903
    [Abstract] [Full Text] [Related]

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  • 15. Myelin abnormality in Charcot-Marie-Tooth type 4J recapitulates features of acquired demyelination.
    Hu B, McCollum M, Ravi V, Arpag S, Moiseev D, Castoro R, Mobley B, Burnette B, Siskind C, Day J, Yawn R, Feely S, Li Y, Yan Q, Shy M, Li J.
    Ann Neurol; 2018 Apr 05; 83(4):756-770. PubMed ID: 29518270
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  • 18. Altered phenotypes due to genetic interaction between the mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c.
    Cao X, Lenk GM, Meisler MH.
    G3 (Bethesda); 2023 Aug 09; 13(8):. PubMed ID: 36691351
    [Abstract] [Full Text] [Related]

  • 19. Reactivation of Lysosomal Ca2+ Efflux Rescues Abnormal Lysosomal Storage in FIG4-Deficient Cells.
    Zou J, Hu B, Arpag S, Yan Q, Hamilton A, Zeng YS, Vanoye CG, Li J.
    J Neurosci; 2015 Apr 29; 35(17):6801-12. PubMed ID: 25926456
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