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Journal Abstract Search

175 related items for PubMed ID: 22588261

  • 1. Ring substituents on substituted benzamide ligands indirectly mediate interactions with position 7.39 of transmembrane helix 7 of the D4 dopamine receptor.
    Ericksen SS, Cummings DF, Teer ME, Amdani S, Schetz JA.
    J Pharmacol Exp Ther; 2012 Aug; 342(2):472-85. PubMed ID: 22588261
    [Abstract] [Full Text] [Related]

  • 2. Transmembrane segment five serines of the D4 dopamine receptor uniquely influence the interactions of dopamine, norepinephrine, and Ro10-4548.
    Cummings DF, Ericksen SS, Goetz A, Schetz JA.
    J Pharmacol Exp Ther; 2010 Jun; 333(3):682-95. PubMed ID: 20215412
    [Abstract] [Full Text] [Related]

  • 3. Dopamine D4/D2 receptor selectivity is determined by A divergent aromatic microdomain contained within the second, third, and seventh membrane-spanning segments.
    Simpson MM, Ballesteros JA, Chiappa V, Chen J, Suehiro M, Hartman DS, Godel T, Snyder LA, Sakmar TP, Javitch JA.
    Mol Pharmacol; 1999 Dec; 56(6):1116-26. PubMed ID: 10570038
    [Abstract] [Full Text] [Related]

  • 4. Three amino acids in the D2 dopamine receptor regulate selective ligand function and affinity.
    Cummings DF, Ericksen SS, Schetz JA.
    J Neurochem; 2009 Jul; 110(1):45-57. PubMed ID: 19486266
    [Abstract] [Full Text] [Related]

  • 5. In vitro pharmacological profile of YM-43611, a novel D2-like receptor antagonist with high affinity and selectivity for dopamine D3 and D4 receptors.
    Hidaka K, Tada S, Matsumoto M, Ohmori J, Tasaki Y, Nomura T, Usuda S, Yamaguchi T.
    Br J Pharmacol; 1996 Apr; 117(8):1625-32. PubMed ID: 8732269
    [Abstract] [Full Text] [Related]

  • 6. Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands.
    Peng X, Wang Q, Mishra Y, Xu J, Reichert DE, Malik M, Taylor M, Luedtke RR, Mach RH.
    Bioorg Med Chem Lett; 2015 Feb 01; 25(3):519-23. PubMed ID: 25556097
    [Abstract] [Full Text] [Related]

  • 7. Molecular modeling of the dopamine D2 and serotonin 5-HT1A receptor binding modes of the enantiomers of 5-OMe-BPAT.
    Homan EJ, Wikström HV, Grol CJ.
    Bioorg Med Chem; 1999 Sep 01; 7(9):1805-20. PubMed ID: 10530928
    [Abstract] [Full Text] [Related]

  • 8. Analogues of Arylamide Phenylpiperazine Ligands To Investigate the Factors Influencing D3 Dopamine Receptor Bitropic Binding and Receptor Subtype Selectivity.
    Hayatshahi HS, Xu K, Griffin SA, Taylor M, Mach RH, Liu J, Luedtke RR.
    ACS Chem Neurosci; 2018 Dec 19; 9(12):2972-2983. PubMed ID: 30010318
    [Abstract] [Full Text] [Related]

  • 9. Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.
    Ehrlich K, Götz A, Bollinger S, Tschammer N, Bettinetti L, Härterich S, Hübner H, Lanig H, Gmeiner P.
    J Med Chem; 2009 Aug 13; 52(15):4923-35. PubMed ID: 19606869
    [Abstract] [Full Text] [Related]

  • 10. Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain.
    Kortagere S, Gmeiner P, Weinstein H, Schetz JA.
    Mol Pharmacol; 2004 Dec 13; 66(6):1491-9. PubMed ID: 15448188
    [Abstract] [Full Text] [Related]

  • 11. Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes.
    Boeckler F, Lanig H, Gmeiner P.
    J Med Chem; 2005 Feb 10; 48(3):694-709. PubMed ID: 15689154
    [Abstract] [Full Text] [Related]

  • 12. Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors.
    Michino M, Free RB, Doyle TB, Sibley DR, Shi L.
    Chem Commun (Camb); 2015 May 21; 51(41):8618-21. PubMed ID: 25896577
    [Abstract] [Full Text] [Related]

  • 13. Bivalent molecular probes for dopamine D2-like receptors.
    Huber D, Löber S, Hübner H, Gmeiner P.
    Bioorg Med Chem; 2012 Jan 01; 20(1):455-66. PubMed ID: 22100258
    [Abstract] [Full Text] [Related]

  • 14. Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.
    Ohmori J, Maeno K, Hidaka K, Nakato K, Matsumoto M, Tada S, Hattori H, Sakamoto S, Tsukamoto S, Usuda S, Mase T.
    J Med Chem; 1996 Jul 05; 39(14):2764-72. PubMed ID: 8709107
    [Abstract] [Full Text] [Related]

  • 15. N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand.
    Perrone R, Berardi F, Colabufo NA, Leopoldo M, Tortorella V.
    J Med Chem; 1998 Nov 19; 41(24):4903-9. PubMed ID: 9822559
    [Abstract] [Full Text] [Related]

  • 16. The development of dopamine D2-receptor selective antagonists.
    Högberg T.
    Drug Des Discov; 1993 Nov 19; 9(3-4):333-50. PubMed ID: 8400011
    [Abstract] [Full Text] [Related]

  • 17. Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors.
    Lacivita E, De Giorgio P, Colabufo NA, Berardi F, Perrone R, Niso M, Leopoldo M.
    Chem Biodivers; 2014 Feb 19; 11(2):299-310. PubMed ID: 24591318
    [Abstract] [Full Text] [Related]

  • 18. A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus.
    Mammoli V, Bonifazi A, Dal Ben D, Giannella M, Giorgioni G, Piergentili A, Pigini M, Quaglia W, Thomas A, Newman AH, Ferré S, Sanchez-Soto M, Keck TM, Del Bello F.
    ChemMedChem; 2016 Aug 19; 11(16):1819-28. PubMed ID: 26990230
    [Abstract] [Full Text] [Related]

  • 19. 2-aminotetralin-derived substituted benzamides with mixed dopamine D2, D3, and serotonin 5-HT1A receptor binding properties: a novel class of potential atypical antipsychotic agents.
    Homan EJ, Copinga S, Elfström L, van der Veen T, Hallema JP, Mohell N, Unelius L, Johansson R, Wikström HV, Grol CJ.
    Bioorg Med Chem; 1998 Nov 19; 6(11):2111-26. PubMed ID: 9881101
    [Abstract] [Full Text] [Related]

  • 20. Contributions of conserved serine residues to the interactions of ligands with dopamine D2 receptors.
    Cox BA, Henningsen RA, Spanoyannis A, Neve RL, Neve KA.
    J Neurochem; 1992 Aug 19; 59(2):627-35. PubMed ID: 1321233
    [Abstract] [Full Text] [Related]

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