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1308 related items for PubMed ID: 22593441

  • 1. Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro.
    Liu H, Scholz C, Zang C, Schefe JH, Habbel P, Regierer AC, Schulz CO, Possinger K, Eucker J.
    Anticancer Res; 2012 May; 32(5):1627-37. PubMed ID: 22593441
    [Abstract] [Full Text] [Related]

  • 2. The mTOR inhibitor RAD001 sensitizes tumor cells to the cytotoxic effect of carboplatin in breast cancer in vitro.
    Liu H, Zang C, Schefe JH, Schwarzlose-Schwarck S, Regierer AC, Elstner E, Schulz CO, Scholz C, Possinger K, Eucker J.
    Anticancer Res; 2011 Sep; 31(9):2713-22. PubMed ID: 21868512
    [Abstract] [Full Text] [Related]

  • 3. Akt and p53 are potential mediators of reduced mammary tumor growth by cloroquine and the mTOR inhibitor RAD001.
    Loehberg CR, Strissel PL, Dittrich R, Strick R, Dittmer J, Dittmer A, Fabry B, Kalender WA, Koch T, Wachter DL, Groh N, Polier A, Brandt I, Lotz L, Hoffmann I, Koppitz F, Oeser S, Mueller A, Fasching PA, Lux MP, Beckmann MW, Schrauder MG.
    Biochem Pharmacol; 2012 Feb 15; 83(4):480-8. PubMed ID: 22142888
    [Abstract] [Full Text] [Related]

  • 4. Effects of a combined treatment with mTOR inhibitor RAD001 and tamoxifen in vitro on growth and apoptosis of human cancer cells.
    Treeck O, Wackwitz B, Haus U, Ortmann O.
    Gynecol Oncol; 2006 Aug 15; 102(2):292-9. PubMed ID: 16443261
    [Abstract] [Full Text] [Related]

  • 5. Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer.
    Boulay A, Rudloff J, Ye J, Zumstein-Mecker S, O'Reilly T, Evans DB, Chen S, Lane HA.
    Clin Cancer Res; 2005 Jul 15; 11(14):5319-28. PubMed ID: 16033851
    [Abstract] [Full Text] [Related]

  • 6. mTOR inhibitor RAD001 (everolimus) induces apoptotic, not autophagic cell death, in human nasopharyngeal carcinoma cells.
    Cai Y, Xia Q, Su Q, Luo R, Sun Y, Shi Y, Jiang W.
    Int J Mol Med; 2013 Apr 15; 31(4):904-12. PubMed ID: 23426850
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.
    deGraffenried LA, Friedrichs WE, Russell DH, Donzis EJ, Middleton AK, Silva JM, Roth RA, Hidalgo M.
    Clin Cancer Res; 2004 Dec 01; 10(23):8059-67. PubMed ID: 15585641
    [Abstract] [Full Text] [Related]

  • 8. Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells.
    Zakikhani M, Blouin MJ, Piura E, Pollak MN.
    Breast Cancer Res Treat; 2010 Aug 01; 123(1):271-9. PubMed ID: 20135346
    [Abstract] [Full Text] [Related]

  • 9. Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.
    Rocha GZ, Dias MM, Ropelle ER, Osório-Costa F, Rossato FA, Vercesi AE, Saad MJ, Carvalheira JB.
    Clin Cancer Res; 2011 Jun 15; 17(12):3993-4005. PubMed ID: 21543517
    [Abstract] [Full Text] [Related]

  • 10. The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway.
    Ji D, Zhang Z, Cheng L, Chang J, Wang S, Zheng B, Zheng R, Sun Z, Wang C, Zhang Z, Liu R, Zhang X, Liu X, Wang X, Li J.
    PLoS One; 2014 Jun 15; 9(1):e85116. PubMed ID: 24416349
    [Abstract] [Full Text] [Related]

  • 11. Synergistic anti-tumor effects of RAD001 with MEK inhibitors in neuroendocrine tumors: a potential mechanism of therapeutic limitation of mTOR inhibitor.
    Iida S, Miki Y, Ono K, Akahira J, Nakamura Y, Suzuki T, Sasano H.
    Mol Cell Endocrinol; 2012 Mar 05; 350(1):99-106. PubMed ID: 22178087
    [Abstract] [Full Text] [Related]

  • 12. Counteracting autophagy overcomes resistance to everolimus in mantle cell lymphoma.
    Rosich L, Xargay-Torrent S, López-Guerra M, Campo E, Colomer D, Roué G.
    Clin Cancer Res; 2012 Oct 01; 18(19):5278-89. PubMed ID: 22879389
    [Abstract] [Full Text] [Related]

  • 13. Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB.
    Menendez JA, Mehmi I, Atlas E, Colomer R, Lupu R.
    Int J Oncol; 2004 Mar 01; 24(3):591-608. PubMed ID: 14767544
    [Abstract] [Full Text] [Related]

  • 14. The mammalian target of rapamycin inhibitor everolimus (RAD001) in early breast cancer: results of a pre-operative study.
    Macaskill EJ, Bartlett JM, Sabine VS, Faratian D, Renshaw L, White S, Campbell FM, Young O, Williams L, Thomas JS, Barber MD, Dixon JM.
    Breast Cancer Res Treat; 2011 Aug 01; 128(3):725-34. PubMed ID: 20941539
    [Abstract] [Full Text] [Related]

  • 15. Inhibition of induced autophagy increases apoptosis of Nara-H cells.
    Nakamura O, Hitora T, Akisue T, Kawamoto T, Yamagami Y, Yamamoto T.
    Int J Oncol; 2011 Dec 01; 39(6):1545-52. PubMed ID: 21805033
    [Abstract] [Full Text] [Related]

  • 16. Limitations in small intestinal neuroendocrine tumor therapy by mTor kinase inhibition reflect growth factor-mediated PI3K feedback loop activation via ERK1/2 and AKT.
    Svejda B, Kidd M, Kazberouk A, Lawrence B, Pfragner R, Modlin IM.
    Cancer; 2011 Sep 15; 117(18):4141-54. PubMed ID: 21387274
    [Abstract] [Full Text] [Related]

  • 17. The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models.
    Zhao H, Cui K, Nie F, Wang L, Brandl MB, Jin G, Li F, Mao Y, Xue Z, Rodriguez A, Chang J, Wong ST.
    Breast Cancer Res Treat; 2012 Jan 15; 131(2):425-36. PubMed ID: 21394501
    [Abstract] [Full Text] [Related]

  • 18. Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma.
    Yazbeck VY, Buglio D, Georgakis GV, Li Y, Iwado E, Romaguera JE, Kondo S, Younes A.
    Exp Hematol; 2008 Apr 15; 36(4):443-50. PubMed ID: 18343280
    [Abstract] [Full Text] [Related]

  • 19. Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt.
    Janjetovic K, Vucicevic L, Misirkic M, Vilimanovich U, Tovilovic G, Zogovic N, Nikolic Z, Jovanovic S, Bumbasirevic V, Trajkovic V, Harhaji-Trajkovic L.
    Eur J Pharmacol; 2011 Jan 25; 651(1-3):41-50. PubMed ID: 21114978
    [Abstract] [Full Text] [Related]

  • 20. Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification.
    Tomioka H, Mukohara T, Kataoka Y, Ekyalongo RC, Funakoshi Y, Imai Y, Kiyota N, Fujiwara Y, Minami H.
    Int J Oncol; 2012 Aug 25; 41(2):551-8. PubMed ID: 22614071
    [Abstract] [Full Text] [Related]

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