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Journal Abstract Search

271 related items for PubMed ID: 22607268

  • 1. Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca²⁺ leak that is impaired by FAD mutations.
    Das HK, Tchedre K, Mueller B.
    J Neurochem; 2012 Aug; 122(3):487-500. PubMed ID: 22607268
    [Abstract] [Full Text] [Related]

  • 2. Thapsigargin affects presenilin-2 but not presenilin-1 regulation in SK-N-BE cells.
    Rivabene R, Visentin S, Piscopo P, De Nuccio C, Crestini A, Svetoni F, Rosa P, Confaloni A.
    Exp Biol Med (Maywood); 2014 Feb; 239(2):213-24. PubMed ID: 24363250
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of basal activity of c-jun-NH2-terminal kinase (JNK) represses the expression of presenilin-1 by a p53-dependent mechanism.
    Lee S, Das HK.
    Brain Res; 2008 May 01; 1207():19-31. PubMed ID: 18374905
    [Abstract] [Full Text] [Related]

  • 4. Membrane topology of human presenilin-1 in SK-N-SH cells determined by fluorescence correlation spectroscopy and fluorescent energy transfer.
    Midde K, Rich R, Saxena A, Gryczynski I, Borejdo J, Das HK.
    Cell Biochem Biophys; 2014 Nov 01; 70(2):923-32. PubMed ID: 24839116
    [Abstract] [Full Text] [Related]

  • 5. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.
    Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L, De Strooper B, Yu G, Bezprozvanny I.
    Cell; 2006 Sep 08; 126(5):981-93. PubMed ID: 16959576
    [Abstract] [Full Text] [Related]

  • 6. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
    Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH.
    Mol Neurobiol; 2015 Dec 08; 52(3):1835-1849. PubMed ID: 25394380
    [Abstract] [Full Text] [Related]

  • 7. Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.
    Nelson O, Tu H, Lei T, Bentahir M, de Strooper B, Bezprozvanny I.
    J Clin Invest; 2007 May 08; 117(5):1230-9. PubMed ID: 17431506
    [Abstract] [Full Text] [Related]

  • 8. Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.
    Zatti G, Burgo A, Giacomello M, Barbiero L, Ghidoni R, Sinigaglia G, Florean C, Bagnoli S, Binetti G, Sorbi S, Pizzo P, Fasolato C.
    Cell Calcium; 2006 Jun 08; 39(6):539-50. PubMed ID: 16620965
    [Abstract] [Full Text] [Related]

  • 9. Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry.
    Tong BC, Lee CS, Cheng WH, Lai KO, Foskett JK, Cheung KH.
    Sci Signal; 2016 Sep 06; 9(444):ra89. PubMed ID: 27601731
    [Abstract] [Full Text] [Related]

  • 10. Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis.
    Rahman M, Zhang Z, Mody AA, Su DM, Das HK.
    Brain Res; 2012 Apr 11; 1448():117-28. PubMed ID: 22353755
    [Abstract] [Full Text] [Related]

  • 11. Transcriptional regulation of the presenilin-1 gene controls gamma-secretase activity.
    Lee S, Das HK.
    Front Biosci (Elite Ed); 2010 Jan 01; 2(1):22-35. PubMed ID: 20036849
    [Abstract] [Full Text] [Related]

  • 12. Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction.
    Popescu BO, Cedazo-Minguez A, Benedikz E, Nishimura T, Winblad B, Ankarcrona M, Cowburn RF.
    J Biol Chem; 2004 Feb 20; 279(8):6455-64. PubMed ID: 14625299
    [Abstract] [Full Text] [Related]

  • 13. Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes.
    Nelson O, Supnet C, Liu H, Bezprozvanny I.
    J Alzheimers Dis; 2010 Feb 20; 21(3):781-93. PubMed ID: 20634584
    [Abstract] [Full Text] [Related]

  • 14. Attenuated presenilin-1 endoproteolysis enhances store-operated calcium currents in neuronal cells.
    Ryazantseva M, Skobeleva K, Glushankova L, Kaznacheyeva E.
    J Neurochem; 2016 Mar 20; 136(5):1085-95. PubMed ID: 26678016
    [Abstract] [Full Text] [Related]

  • 15. Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors.
    Ma L, Ohyagi Y, Miyoshi K, Sakae N, Motomura K, Taniwaki T, Furuya H, Takeda K, Tabira T, Kira J.
    J Alzheimers Dis; 2009 Mar 20; 16(3):565-75. PubMed ID: 19276551
    [Abstract] [Full Text] [Related]

  • 16. Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.
    Honarnejad K, Jung CK, Lammich S, Arzberger T, Kretzschmar H, Herms J.
    J Cell Mol Med; 2013 Feb 20; 17(2):293-302. PubMed ID: 23379308
    [Abstract] [Full Text] [Related]

  • 17. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.
    Biochemistry; 1998 Nov 24; 37(47):16465-71. PubMed ID: 9843412
    [Abstract] [Full Text] [Related]

  • 18. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.
    Katayama T, Imaizumi K, Sato N, Miyoshi K, Kudo T, Hitomi J, Morihara T, Yoneda T, Gomi F, Mori Y, Nakano Y, Takeda J, Tsuda T, Itoyama Y, Murayama O, Takashima A, St George-Hyslop P, Takeda M, Tohyama M.
    Nat Cell Biol; 1999 Dec 24; 1(8):479-85. PubMed ID: 10587643
    [Abstract] [Full Text] [Related]

  • 19. Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM.
    Pastorcic M, Das HK.
    Brain Res; 2007 Jan 12; 1128(1):21-32. PubMed ID: 17126306
    [Abstract] [Full Text] [Related]

  • 20. Up-regulation of inositol 1,4,5-trisphosphate receptor type 1 is responsible for a decreased endoplasmic-reticulum Ca2+ content in presenilin double knock-out cells.
    Kasri NN, Kocks SL, Verbert L, Hébert SS, Callewaert G, Parys JB, Missiaen L, De Smedt H.
    Cell Calcium; 2006 Jul 12; 40(1):41-51. PubMed ID: 16675011
    [Abstract] [Full Text] [Related]

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