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217 related items for PubMed ID: 22652174

  • 1. A new protoapigenone analog RY10-4 induces apoptosis and suppresses invasion through the PI3K/Akt pathway in human breast cancer.
    Yuan Q, Cai S, Zhang X, Liu Z, Li Z, Luo X, Xiong C, Wang J, Hu J, Ruan J.
    Cancer Lett; 2012 Nov 28; 324(2):210-20. PubMed ID: 22652174
    [Abstract] [Full Text] [Related]

  • 2. A novel protoapigenone analog RY10-4 induces breast cancer MCF-7 cell death through autophagy via the Akt/mTOR pathway.
    Zhang X, Wei H, Liu Z, Yuan Q, Wei A, Shi D, Yang X, Ruan J.
    Toxicol Appl Pharmacol; 2013 Jul 15; 270(2):122-8. PubMed ID: 23624174
    [Abstract] [Full Text] [Related]

  • 3. RY10-4, a novel anti-tumor compound, exhibited its anti-angiogenesis activity by down-regulation of the HIF-1α and inhibition phosphorylation of AKT and mTOR.
    Liu Z, Yuan Q, Zhang X, Xiong C, Xue P, Ruan J.
    Cancer Chemother Pharmacol; 2012 Jun 15; 69(6):1633-40. PubMed ID: 22565593
    [Abstract] [Full Text] [Related]

  • 4. KRC-408, a novel c-Met inhibitor, suppresses cell proliferation and angiogenesis of gastric cancer.
    Hong SW, Jung KH, Park BH, Zheng HM, Lee HS, Choi MJ, Yun JI, Kang NS, Lee J, Hong SS.
    Cancer Lett; 2013 May 10; 332(1):74-82. PubMed ID: 23348694
    [Abstract] [Full Text] [Related]

  • 5. Combination therapy of RY10-4 with the γ-secretase inhibitor DAPT shows promise in treating HER2-amplified breast cancer.
    Su F, Zhu S, Ruan J, Muftuoglu Y, Zhang L, Yuan Q.
    Oncotarget; 2016 Jan 26; 7(4):4142-54. PubMed ID: 26716652
    [Abstract] [Full Text] [Related]

  • 6. PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo.
    Ma JG, Huang H, Chen SM, Chen Y, Xin XL, Lin LP, Ding J, Liu H, Meng LH.
    Breast Cancer Res Treat; 2011 Nov 26; 130(1):85-96. PubMed ID: 21181437
    [Abstract] [Full Text] [Related]

  • 7. RY10-4 suppressed metastasis of MDA-MB-231 by stabilizing ECM and E-cadherin.
    Liu Z, Liu Z, Zhang X, Xue P, Zhang H.
    Biomed Pharmacother; 2014 May 26; 68(4):439-45. PubMed ID: 24721328
    [Abstract] [Full Text] [Related]

  • 8. DC120, a novel and potent inhibitor of AKT kinase, induces tumor cell apoptosis and suppresses tumor growth.
    Deng R, Yang F, Chang SH, Tang J, Qin J, Feng GK, Ding K, Zhu XF.
    Mol Pharmacol; 2012 Aug 26; 82(2):189-98. PubMed ID: 22553359
    [Abstract] [Full Text] [Related]

  • 9. Anti-tumor compound RY10-4 suppresses multidrug resistance in MCF-7/ADR cells by inhibiting PI3K/Akt/NF-κB signaling.
    Yang X, Ding Y, Xiao M, Liu X, Ruan J, Xue P.
    Chem Biol Interact; 2017 Dec 25; 278():22-31. PubMed ID: 28987325
    [Abstract] [Full Text] [Related]

  • 10. A novel imidazopyridine analogue as a phosphatidylinositol 3-kinase inhibitor against human breast cancer.
    Lee H, Li GY, Jeong Y, Jung KH, Lee JH, Ham K, Hong S, Hong SS.
    Cancer Lett; 2012 May 01; 318(1):68-75. PubMed ID: 22155744
    [Abstract] [Full Text] [Related]

  • 11. RL71, a second-generation curcumin analog, induces apoptosis and downregulates Akt in ER-negative breast cancer cells.
    Yadav B, Taurin S, Larsen L, Rosengren RJ.
    Int J Oncol; 2012 Sep 01; 41(3):1119-27. PubMed ID: 22710975
    [Abstract] [Full Text] [Related]

  • 12. HS-116, a novel phosphatidylinositol 3-kinase inhibitor induces apoptosis and suppresses angiogenesis of hepatocellular carcinoma through inhibition of the PI3K/AKT/mTOR pathway.
    Jung KH, Choi MJ, Hong S, Lee H, Hong SW, Zheng HM, Lee HS, Hong S, Hong SS.
    Cancer Lett; 2012 Mar 28; 316(2):187-95. PubMed ID: 22182943
    [Abstract] [Full Text] [Related]

  • 13. Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro.
    Fernand VE, Losso JN, Truax RE, Villar EE, Bwambok DK, Fakayode SO, Lowry M, Warner IM.
    Chem Biol Interact; 2011 Jul 15; 192(3):220-32. PubMed ID: 21457705
    [Abstract] [Full Text] [Related]

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  • 15. A novel protoapigenone analog RY10-4 induces apoptosis of breast cancer cells by exacerbating mitochondrial Ca2+ influx through mitochondrial calcium uniporter.
    Xue P, Chen Q, Ren X, Liu D, Yang X.
    Toxicol Appl Pharmacol; 2021 Dec 15; 433():115776. PubMed ID: 34717963
    [Abstract] [Full Text] [Related]

  • 16. A novel herbal formula induces cell cycle arrest and apoptosis in association with suppressing the PI3K/AKT pathway in human lung cancer A549 cells.
    Xiong F, Jiang M, Huang Z, Chen M, Chen K, Zhou J, Yin L, Tang Y, Wang M, Ye L, Zhan Z, Duan J, Fu H, Zhang X.
    Integr Cancer Ther; 2014 Mar 15; 13(2):152-60. PubMed ID: 24105357
    [Abstract] [Full Text] [Related]

  • 17. Apigenin inhibits HGF-promoted invasive growth and metastasis involving blocking PI3K/Akt pathway and beta 4 integrin function in MDA-MB-231 breast cancer cells.
    Lee WJ, Chen WK, Wang CJ, Lin WL, Tseng TH.
    Toxicol Appl Pharmacol; 2008 Jan 15; 226(2):178-91. PubMed ID: 17961621
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of cell survival, cell cycle progression, tumor growth and cyclooxygenase-2 activity in MDA-MB-231 breast cancer cells by camphorataimide B.
    Lin WL, Lee YJ, Wang SM, Huang PY, Tseng TH.
    Eur J Pharmacol; 2012 Apr 05; 680(1-3):8-15. PubMed ID: 22329896
    [Abstract] [Full Text] [Related]

  • 19. Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway.
    Thoennissen NH, O'Kelly J, Lu D, Iwanski GB, La DT, Abbassi S, Leiter A, Karlan B, Mehta R, Koeffler HP.
    Oncogene; 2010 Jan 14; 29(2):285-96. PubMed ID: 19855437
    [Abstract] [Full Text] [Related]

  • 20. Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo.
    Chen J, Zeng J, Xin M, Huang W, Chen X.
    Horm Metab Res; 2011 Sep 14; 43(10):681-6. PubMed ID: 21932171
    [Abstract] [Full Text] [Related]

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