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Journal Abstract Search

166 related items for PubMed ID: 22659146

  • 1. Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): implications for protection against UV radiation during thiopurine therapy.
    Kalra S, Knatko EV, Zhang Y, Honda T, Yamamoto M, Dinkova-Kostova AT.
    Cancer Prev Res (Phila); 2012 Jul; 5(7):973-81. PubMed ID: 22659146
    [Abstract] [Full Text] [Related]

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  • 3. Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans.
    Knatko EV, Ibbotson SH, Zhang Y, Higgins M, Fahey JW, Talalay P, Dawe RS, Ferguson J, Huang JT, Clarke R, Zheng S, Saito A, Kalra S, Benedict AL, Honda T, Proby CM, Dinkova-Kostova AT.
    Cancer Prev Res (Phila); 2015 Jun; 8(6):475-86. PubMed ID: 25804610
    [Abstract] [Full Text] [Related]

  • 4. The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress.
    Benedict AL, Knatko EV, Dinkova-Kostova AT.
    Carcinogenesis; 2012 Dec; 33(12):2457-66. PubMed ID: 22983983
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  • 5. Ultraviolet A irradiation induces NF-E2-related factor 2 activation in dermal fibroblasts: protective role in UVA-induced apoptosis.
    Hirota A, Kawachi Y, Itoh K, Nakamura Y, Xu X, Banno T, Takahashi T, Yamamoto M, Otsuka F.
    J Invest Dermatol; 2005 Apr; 124(4):825-32. PubMed ID: 15816842
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  • 7. Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species.
    Reisman SA, Yeager RL, Yamamoto M, Klaassen CD.
    Toxicol Sci; 2009 Mar; 108(1):35-47. PubMed ID: 19129213
    [Abstract] [Full Text] [Related]

  • 8. An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1.
    Dinkova-Kostova AT, Talalay P, Sharkey J, Zhang Y, Holtzclaw WD, Wang XJ, David E, Schiavoni KH, Finlayson S, Mierke DF, Honda T.
    J Biol Chem; 2010 Oct 29; 285(44):33747-55. PubMed ID: 20801881
    [Abstract] [Full Text] [Related]

  • 9. Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.
    Kostov RV, Knatko EV, McLaughlin LA, Henderson CJ, Zheng S, Huang JT, Honda T, Dinkova-Kostova AT.
    Biochem Biophys Res Commun; 2015 Sep 25; 465(3):402-7. PubMed ID: 26265043
    [Abstract] [Full Text] [Related]

  • 10. KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants.
    Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW.
    J Hepatol; 2013 Dec 25; 59(6):1200-7. PubMed ID: 23867319
    [Abstract] [Full Text] [Related]

  • 11. Resveratrol protects human keratinocytes HaCaT cells from UVA-induced oxidative stress damage by downregulating Keap1 expression.
    Liu Y, Chan F, Sun H, Yan J, Fan D, Zhao D, An J, Zhou D.
    Eur J Pharmacol; 2011 Jan 10; 650(1):130-7. PubMed ID: 20951123
    [Abstract] [Full Text] [Related]

  • 12. C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape.
    Dayalan Naidu S, Muramatsu A, Saito R, Asami S, Honda T, Hosoya T, Itoh K, Yamamoto M, Suzuki T, Dinkova-Kostova AT.
    Sci Rep; 2018 May 23; 8(1):8037. PubMed ID: 29795117
    [Abstract] [Full Text] [Related]

  • 13. Caffeic acid derivatives isolated from Galinsoga parviflora herb protected human dermal fibroblasts from UVA-radiation.
    Parzonko A, Kiss AK.
    Phytomedicine; 2019 Apr 23; 57():215-222. PubMed ID: 30785017
    [Abstract] [Full Text] [Related]

  • 14. Obacunone protects retinal pigment epithelium cells from ultra-violet radiation-induced oxidative injury.
    Huang DR, Dai CM, Li SY, Li XF.
    Aging (Albany NY); 2021 Feb 01; 13(8):11010-11025. PubMed ID: 33535179
    [Abstract] [Full Text] [Related]

  • 15. Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity.
    Williamson TP, Johnson DA, Johnson JA.
    Neurotoxicology; 2012 Jun 01; 33(3):272-9. PubMed ID: 22342405
    [Abstract] [Full Text] [Related]

  • 16. Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2.
    Tao S, Park SL, Rojo de la Vega M, Zhang DD, Wondrak GT.
    Free Radic Biol Med; 2015 Dec 01; 89():690-700. PubMed ID: 26456052
    [Abstract] [Full Text] [Related]

  • 17. Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.
    Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB.
    Cancer Res; 2013 Apr 01; 73(7):2199-210. PubMed ID: 23382044
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  • 19. Activation of Nrf2 in defense against cadmium-induced oxidative stress.
    He X, Chen MG, Ma Q.
    Chem Res Toxicol; 2008 Jul 01; 21(7):1375-83. PubMed ID: 18512965
    [Abstract] [Full Text] [Related]

  • 20. Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesis.
    Ohkoshi A, Suzuki T, Ono M, Kobayashi T, Yamamoto M.
    Cancer Prev Res (Phila); 2013 Feb 01; 6(2):149-59. PubMed ID: 23250896
    [Abstract] [Full Text] [Related]

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