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Journal Abstract Search

156 related items for PubMed ID: 22664127

  • 1. Antagonists of 5-HT₆ receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines-Synthesis and 'structure-activity' relationship.
    Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Vorobiev AA, Okun I.
    Bioorg Med Chem Lett; 2012 Jul 01; 22(13):4273-80. PubMed ID: 22664127
    [Abstract] [Full Text] [Related]

  • 2. Synthesis of cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines and their evaluation as 5-HT6 receptor antagonists.
    Ivachtchenko AV, Dmitriev DE, Golovina ES, Dubrovskaya ES, Kadieva MG, Koryakova AG, Kysil VM, Mitkin OD, Tkachenko SE, Okun IM, Vorobiov AA.
    Bioorg Med Chem Lett; 2010 Apr 01; 20(7):2133-6. PubMed ID: 20207539
    [Abstract] [Full Text] [Related]

  • 3. (3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: potent and selective antagonists of the serotonin 5-HT6 receptor.
    Ivachtchenko AV, Dmitriev DE, Golovina ES, Kadieva MG, Koryakova AG, Kysil VM, Mitkin OD, Okun IM, Tkachenko SE, Vorobiev AA.
    J Med Chem; 2010 Jul 22; 53(14):5186-96. PubMed ID: 20560595
    [Abstract] [Full Text] [Related]

  • 4. 2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: new series of highly potent and specific serotonin 5-HT6 receptor antagonists.
    Ivachtchenko AV, Golovina ES, Kadieva MG, Koryakova AG, Mitkin OD, Tkachenko SE, Kysil VM, Okun I.
    Eur J Med Chem; 2011 Apr 22; 46(4):1189-97. PubMed ID: 21333408
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.
    Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Tkachenko SE, Okun IM.
    J Med Chem; 2011 Dec 08; 54(23):8161-73. PubMed ID: 22029285
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists.
    Ivachtchenko AV, Golovina ES, Kadieva MG, Kysil VM, Mitkin OD, Tkachenko SE, Okun I.
    Bioorg Med Chem; 2011 Feb 15; 19(4):1482-91. PubMed ID: 21277782
    [Abstract] [Full Text] [Related]

  • 7. Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.
    Baraldi PG, Fruttarolo F, Tabrizi MA, Preti D, Romagnoli R, El-Kashef H, Moorman A, Varani K, Gessi S, Merighi S, Borea PA.
    J Med Chem; 2003 Mar 27; 46(7):1229-41. PubMed ID: 12646033
    [Abstract] [Full Text] [Related]

  • 8. Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.
    Wu YJ, He H, Hu S, Huang Y, Scola PM, Grant-Young K, Bertekap RL, Wu D, Gao Q, Li Y, Klakouski C, Westphal RS.
    J Med Chem; 2003 Nov 06; 46(23):4834-7. PubMed ID: 14584934
    [Abstract] [Full Text] [Related]

  • 9. A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787.
    Andaloussi M, Lim HD, van der Meer T, Sijm M, Poulie CB, de Esch IJ, Leurs R, Smits RA.
    Bioorg Med Chem Lett; 2013 May 01; 23(9):2663-70. PubMed ID: 23558237
    [Abstract] [Full Text] [Related]

  • 10. Synthesis of 7-(2-dimethylaminovinyl) derivatives of pyrazolo[1,5-a] pyrimidines, as precursors of new tricyclic series. Binding studies of BDZ receptor.
    Bruni F, Costanzo A, Selleri S, Guerrini G, Giusti L, Martini C, Lucacchini A.
    Farmaco; 1993 Feb 01; 48(2):309-19. PubMed ID: 8388217
    [Abstract] [Full Text] [Related]

  • 11. 1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile.
    Hunt HJ, Belanoff JK, Golding E, Gourdet B, Phillips T, Swift D, Thomas J, Unitt JF, Walters I.
    Bioorg Med Chem Lett; 2015 Dec 15; 25(24):5720-5. PubMed ID: 26546213
    [Abstract] [Full Text] [Related]

  • 12. Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines.
    Alberti MJ, Auten EP, Lackey KE, McDonald OB, Wood ER, Preugschat F, Cutler GJ, Kane-Carson L, Liu W, Jung DK.
    Bioorg Med Chem Lett; 2005 Aug 15; 15(16):3778-81. PubMed ID: 15993060
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  • 18. Novel brain penetrant benzofuropiperidine 5-HT₆ receptor antagonists.
    Sundar BG, Bailey TR, Dunn DD, Bacon ER, Salvino JM, Morton GC, Aimone LD, Zeqi H, Mathiasen JR, Dicamillo A, Huffman MJ, McKenna BA, Kopec K, Lu LD, Brown R, Qian J, Angeles T, Connors T, Spais C, Holskin B, Galinis D, Duzic E, Schaffhauser H, Rosse GC.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):120-3. PubMed ID: 22153937
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  • 19. Synthesis and biological evaluation of 7-(aminoalkyl)pyrazolo[1,5-a]pyrimidine derivatives as cathepsin K inhibitors.
    Petek N, Štefane B, Novinec M, Svete J.
    Bioorg Chem; 2019 Mar 01; 84():226-238. PubMed ID: 30502634
    [Abstract] [Full Text] [Related]

  • 20. Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists.
    Wustrow DJ, Capiris T, Rubin R, Knobelsdorf JA, Akunne H, Davis MD, MacKenzie R, Pugsley TA, Zoski KT, Heffner TG, Wise LD.
    Bioorg Med Chem Lett; 1998 Aug 18; 8(16):2067-70. PubMed ID: 9873487
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