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342 related items for PubMed ID: 22687511
1. Understanding the molecular determinants of substrate and inhibitor specificities in the Carbapenemase KPC-2: exploring the roles of Arg220 and Glu276. Papp-Wallace KM, Taracila MA, Smith KM, Xu Y, Bonomo RA. Antimicrob Agents Chemother; 2012 Aug; 56(8):4428-38. PubMed ID: 22687511 [Abstract] [Full Text] [Related]
2. Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering. Barnes MD, Winkler ML, Taracila MA, Page MG, Desarbre E, Kreiswirth BN, Shields RK, Nguyen MH, Clancy C, Spellberg B, Papp-Wallace KM, Bonomo RA. mBio; 2017 Oct 31; 8(5):. PubMed ID: 29089425 [Abstract] [Full Text] [Related]
7. Nacubactam Enhances Meropenem Activity against Carbapenem-Resistant Klebsiella pneumoniae Producing KPC. Barnes MD, Taracila MA, Good CE, Bajaksouzian S, Rojas LJ, van Duin D, Kreiswirth BN, Jacobs MR, Haldimann A, Papp-Wallace KM, Bonomo RA. Antimicrob Agents Chemother; 2019 Aug 31; 63(8):. PubMed ID: 31182530 [Abstract] [Full Text] [Related]
8. Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase. Papp-Wallace KM, Bethel CR, Distler AM, Kasuboski C, Taracila M, Bonomo RA. Antimicrob Agents Chemother; 2010 Feb 31; 54(2):890-7. PubMed ID: 20008772 [Abstract] [Full Text] [Related]
9. Elucidating the role of Trp105 in the KPC-2 β-lactamase. Papp-Wallace KM, Taracila M, Wallace CJ, Hujer KM, Bethel CR, Hornick JM, Bonomo RA. Protein Sci; 2010 Sep 31; 19(9):1714-27. PubMed ID: 20662006 [Abstract] [Full Text] [Related]
15. Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 β-lactamase. Furey IM, Mehta SC, Sankaran B, Hu L, Prasad BVV, Palzkill T. J Biol Chem; 2021 Aug 08; 296():100799. PubMed ID: 34022225 [Abstract] [Full Text] [Related]
18. The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276. Drawz SM, Bethel CR, Hujer KM, Hurless KN, Distler AM, Caselli E, Prati F, Bonomo RA. Biochemistry; 2009 Jun 02; 48(21):4557-66. PubMed ID: 19351161 [Abstract] [Full Text] [Related]
19. Overcoming resistance to beta-lactamase inhibitors: comparing sulbactam to novel inhibitors against clavulanate resistant SHV enzymes with substitutions at Ambler position 244. Thomson JM, Distler AM, Bonomo RA. Biochemistry; 2007 Oct 09; 46(40):11361-8. PubMed ID: 17848099 [Abstract] [Full Text] [Related]
20. Crystal structure of KPC-2: insights into carbapenemase activity in class A beta-lactamases. Ke W, Bethel CR, Thomson JM, Bonomo RA, van den Akker F. Biochemistry; 2007 May 15; 46(19):5732-40. PubMed ID: 17441734 [Abstract] [Full Text] [Related] Page: [Next] [New Search]