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Journal Abstract Search


342 related items for PubMed ID: 22687511

  • 1. Understanding the molecular determinants of substrate and inhibitor specificities in the Carbapenemase KPC-2: exploring the roles of Arg220 and Glu276.
    Papp-Wallace KM, Taracila MA, Smith KM, Xu Y, Bonomo RA.
    Antimicrob Agents Chemother; 2012 Aug; 56(8):4428-38. PubMed ID: 22687511
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  • 2. Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering.
    Barnes MD, Winkler ML, Taracila MA, Page MG, Desarbre E, Kreiswirth BN, Shields RK, Nguyen MH, Clancy C, Spellberg B, Papp-Wallace KM, Bonomo RA.
    mBio; 2017 Oct 31; 8(5):. PubMed ID: 29089425
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  • 7. Nacubactam Enhances Meropenem Activity against Carbapenem-Resistant Klebsiella pneumoniae Producing KPC.
    Barnes MD, Taracila MA, Good CE, Bajaksouzian S, Rojas LJ, van Duin D, Kreiswirth BN, Jacobs MR, Haldimann A, Papp-Wallace KM, Bonomo RA.
    Antimicrob Agents Chemother; 2019 Aug 31; 63(8):. PubMed ID: 31182530
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  • 8. Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase.
    Papp-Wallace KM, Bethel CR, Distler AM, Kasuboski C, Taracila M, Bonomo RA.
    Antimicrob Agents Chemother; 2010 Feb 31; 54(2):890-7. PubMed ID: 20008772
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  • 9. Elucidating the role of Trp105 in the KPC-2 β-lactamase.
    Papp-Wallace KM, Taracila M, Wallace CJ, Hujer KM, Bethel CR, Hornick JM, Bonomo RA.
    Protein Sci; 2010 Sep 31; 19(9):1714-27. PubMed ID: 20662006
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  • 11. Characterization of GQA as a novel β-lactamase inhibitor of CTX-M-15 and KPC-2 enzymes.
    Al-Madboly LA, El-Salam MAA, Bastos JK, Aboukhatwa S, El-Morsi RM.
    Microb Cell Fact; 2024 Aug 08; 23(1):221. PubMed ID: 39118086
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  • 15. Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 β-lactamase.
    Furey IM, Mehta SC, Sankaran B, Hu L, Prasad BVV, Palzkill T.
    J Biol Chem; 2021 Aug 08; 296():100799. PubMed ID: 34022225
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  • 17. Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance.
    Tooke CL, Hinchliffe P, Bonomo RA, Schofield CJ, Mulholland AJ, Spencer J.
    J Biol Chem; 2021 Aug 08; 296():100126. PubMed ID: 33257320
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  • 18. The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.
    Drawz SM, Bethel CR, Hujer KM, Hurless KN, Distler AM, Caselli E, Prati F, Bonomo RA.
    Biochemistry; 2009 Jun 02; 48(21):4557-66. PubMed ID: 19351161
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  • 19. Overcoming resistance to beta-lactamase inhibitors: comparing sulbactam to novel inhibitors against clavulanate resistant SHV enzymes with substitutions at Ambler position 244.
    Thomson JM, Distler AM, Bonomo RA.
    Biochemistry; 2007 Oct 09; 46(40):11361-8. PubMed ID: 17848099
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  • 20. Crystal structure of KPC-2: insights into carbapenemase activity in class A beta-lactamases.
    Ke W, Bethel CR, Thomson JM, Bonomo RA, van den Akker F.
    Biochemistry; 2007 May 15; 46(19):5732-40. PubMed ID: 17441734
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