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Journal Abstract Search

196 related items for PubMed ID: 22711749

  • 1. The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.
    Morrison RD, Blobaum AL, Byers FW, Santomango TS, Bridges TM, Stec D, Brewer KA, Sanchez-Ponce R, Corlew MM, Rush R, Felts AS, Manka J, Bates BS, Venable DF, Rodriguez AL, Jones CK, Niswender CM, Conn PJ, Lindsley CW, Emmitte KA, Daniels JS.
    Drug Metab Dispos; 2012 Sep; 40(9):1834-45. PubMed ID: 22711749
    [Abstract] [Full Text] [Related]

  • 2. Species-Specific Involvement of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of the Pyrimidine-Containing mGlu5-Negative Allosteric Modulator VU0424238 (Auglurant).
    Crouch RD, Blobaum AL, Felts AS, Conn PJ, Lindsley CW.
    Drug Metab Dispos; 2017 Dec; 45(12):1245-1259. PubMed ID: 28939686
    [Abstract] [Full Text] [Related]

  • 3. A novel ring oxidation of 4- or 5-substituted 2H-oxazole to corresponding 2-oxazolone catalyzed by cytosolic aldehyde oxidase.
    Arora VK, Philip T, Huang S, Shu YZ.
    Drug Metab Dispos; 2012 Sep; 40(9):1668-76. PubMed ID: 22621803
    [Abstract] [Full Text] [Related]

  • 4. Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach.
    Adusumalli S, Jamwal R, Obach RS, Ryder TF, Leggio L, Akhlaghi F.
    Drug Metab Dispos; 2019 Aug; 47(8):874-882. PubMed ID: 31182423
    [Abstract] [Full Text] [Related]

  • 5. Evaluating the Disposition of a Mixed Aldehyde Oxidase/Cytochrome P450 Substrate in Rats with Attenuated P450 Activity.
    Crouch RD, Morrison RD, Byers FW, Lindsley CW, Emmitte KA, Daniels JS.
    Drug Metab Dispos; 2016 Aug; 44(8):1296-303. PubMed ID: 26936972
    [Abstract] [Full Text] [Related]

  • 6. In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver.
    Rashidi MR, Smith JA, Clarke SE, Beedham C.
    Drug Metab Dispos; 1997 Jul; 25(7):805-13. PubMed ID: 9224775
    [Abstract] [Full Text] [Related]

  • 7. In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401.
    Zhang JW, Deng HB, Zhang CY, Dai JQ, Li Q, Zheng QG, Wan HX, Yu HP, He F, Xu YC, Zhao S, Zhang JYJ.
    Eur J Drug Metab Pharmacokinet; 2019 Oct; 44(5):669-680. PubMed ID: 31030415
    [Abstract] [Full Text] [Related]

  • 8. Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.
    Felts AS, Rodriguez AL, Morrison RD, Venable DF, Manka JT, Bates BS, Blobaum AL, Byers FW, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Emmitte KA.
    Bioorg Med Chem Lett; 2013 Nov 01; 23(21):5779-85. PubMed ID: 24074843
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of xanthine oxidase by the aldehyde oxidase inhibitor raloxifene: implications for identifying molybdopterin nitrite reductases.
    Weidert ER, Schoenborn SO, Cantu-Medellin N, Choughule KV, Jones JP, Kelley EE.
    Nitric Oxide; 2014 Feb 15; 37():41-5. PubMed ID: 24406683
    [Abstract] [Full Text] [Related]

  • 10. In vitro studies on the oxidative metabolism of 20(s)-ginsenoside Rh2 in human, monkey, dog, rat, and mouse liver microsomes, and human liver s9.
    Li L, Chen X, Zhou J, Zhong D.
    Drug Metab Dispos; 2012 Oct 15; 40(10):2041-53. PubMed ID: 22829543
    [Abstract] [Full Text] [Related]

  • 11. In vitro metabolism of tirilazad mesylate in male and female rats. Contribution of cytochrome P4502C11 and delta 4-5 alpha-reductase.
    Wienkers LC, Steenwyk RC, Mizsak SA, Pearson PG.
    Drug Metab Dispos; 1995 Mar 15; 23(3):383-92. PubMed ID: 7628305
    [Abstract] [Full Text] [Related]

  • 12. Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite.
    Glaenzel U, Jin Y, Hansen R, Schroer K, Rahmanzadeh G, Pfaar U, Jaap van Lier J, Borell H, Meissner A, Camenisch G, Zhao S.
    Drug Metab Dispos; 2020 Oct 15; 48(10):873-885. PubMed ID: 32665418
    [Abstract] [Full Text] [Related]

  • 13. In vitro metabolism of the analgesic bicifadine in the mouse, rat, monkey, and human.
    Erickson DA, Hollfelder S, Tenge J, Gohdes M, Burkhardt JJ, Krieter PA.
    Drug Metab Dispos; 2007 Dec 15; 35(12):2232-41. PubMed ID: 17881661
    [Abstract] [Full Text] [Related]

  • 14. Aldehyde oxidase-dependent species difference in hepatic metabolism of fasudil to hydroxyfasudil.
    Mao Z, Wu Y, Li Q, Wang X, Liu Y, Di X.
    Xenobiotica; 2018 Feb 15; 48(2):170-177. PubMed ID: 28166443
    [Abstract] [Full Text] [Related]

  • 15. Oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase.
    Inoue K, Mizuo H, Kawaguchi S, Fukuda K, Kusano K, Yoshimura T.
    Drug Metab Dispos; 2014 Aug 15; 42(8):1326-33. PubMed ID: 24914245
    [Abstract] [Full Text] [Related]

  • 16. In vitro study of 6-mercaptopurine oxidation catalysed by aldehyde oxidase and xanthine oxidase.
    Rashidi MR, Beedham C, Smith JS, Davaran S.
    Drug Metab Pharmacokinet; 2007 Aug 15; 22(4):299-306. PubMed ID: 17827784
    [Abstract] [Full Text] [Related]

  • 17. Why do most human liver cytosol preparations lack xanthine oxidase activity?
    Barr JT, Choughule KV, Nepal S, Wong T, Chaudhry AS, Joswig-Jones CA, Zientek M, Strom SC, Schuetz EG, Thummel KE, Jones JP.
    Drug Metab Dispos; 2014 Apr 15; 42(4):695-9. PubMed ID: 24430612
    [Abstract] [Full Text] [Related]

  • 18. Metabolism of 2-phenylethylamine to phenylacetic acid, via the intermediate phenylacetaldehyde, by freshly prepared and cryopreserved guinea pig liver slices.
    Panoutsopoulos GI.
    In Vivo; 2004 Apr 15; 18(6):779-86. PubMed ID: 15646820
    [Abstract] [Full Text] [Related]

  • 19. Human Aldehyde Oxidase 1-Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes.
    Uehara S, Yoneda N, Higuchi Y, Yamazaki H, Suemizu H.
    Drug Metab Dispos; 2020 Jul 15; 48(7):580-586. PubMed ID: 32357972
    [Abstract] [Full Text] [Related]

  • 20. In vitro binding of a radio-labeled positive allosteric modulator for metabotropic glutamate receptor subtype 5.
    Zysk JR, Spear N, Fieles W, Stein MM, Sygowski LS, King MM, Hoesch V, Hastings R, Brockel B, Do M, Ström P, Gadient R, Chhajlani V, Elmore CS, Maier DL.
    Synapse; 2013 Mar 15; 67(3):135-44. PubMed ID: 23150216
    [Abstract] [Full Text] [Related]

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