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Journal Abstract Search

94 related items for PubMed ID: 22721384

  • 1. The therapeutical potential of a novel pterocarpanquinone LQB-118 to target inhibitor of apoptosis proteins in acute myeloid leukemia cells.
    de Souza Reis FR, de Faria FC, Castro CP, de Souza PS, da Cunha Vasconcelos F, Bello RD, da Silva AJ, Costa PR, Maia RC.
    Anticancer Agents Med Chem; 2013 Feb; 13(2):341-51. PubMed ID: 22721384
    [Abstract] [Full Text] [Related]

  • 2. The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors.
    Nestal de Moraes G, Castro CP, Salustiano EJ, Dumas ML, Costas F, Lam EW, Costa PR, Maia RC.
    Int J Oncol; 2014 Nov; 45(5):1949-58. PubMed ID: 25174716
    [Abstract] [Full Text] [Related]

  • 3. LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells.
    Maia RC, Vasconcelos FC, de Sá Bacelar T, Salustiano EJ, da Silva LF, Pereira DL, Moellman-Coelho A, Netto CD, da Silva AJ, Rumjanek VM, Costa PR.
    Invest New Drugs; 2011 Dec; 29(6):1143-55. PubMed ID: 20499132
    [Abstract] [Full Text] [Related]

  • 4. Insights into the Biological Evaluation of Pterocarpanquinones and Carbapterocarpans with Anti-tumor Activity against MDR Leukemias.
    Rumjanek VM, Maia RC, Salustiano EJ, Costa PRR.
    Anticancer Agents Med Chem; 2019 Dec; 19(1):29-37. PubMed ID: 29692266
    [Abstract] [Full Text] [Related]

  • 5. The LQB-223 Compound Modulates Antiapoptotic Proteins and Impairs Breast Cancer Cell Growth and Migration.
    Lemos LGT, Longo GMDC, Mendonça BDS, Robaina MC, Brum MCM, Cirilo CA, Gimba ERP, Costa PRR, Buarque CD, Nestal de Moraes G, Maia RC.
    Int J Mol Sci; 2019 Oct 12; 20(20):. PubMed ID: 31614718
    [Abstract] [Full Text] [Related]

  • 6. The pterocarpanquinone LQB‑118 compound induces apoptosis of cytarabine‑resistant acute myeloid leukemia cells.
    Hancio T, Mazzoccoli L, Guimarães G, Robaina M, Mendonça BDS, Nestal De Moraes G, Monte-Mor BDCR, Mayumi Gutiyama L, De Carvalho LO, Netto CD, Costa PRR, De Faria FCC, Maia RC.
    Int J Oncol; 2021 Jun 12; 58(6):. PubMed ID: 33786613
    [Abstract] [Full Text] [Related]

  • 7. The pterocarpanquinone LQB 118 induces apoptosis in tumor cells through the intrinsic pathway and the endoplasmic reticulum stress pathway.
    de Sá Bacelar T, da Silva AJ, Costa PR, Rumjanek VM.
    Anticancer Drugs; 2013 Jan 12; 24(1):73-83. PubMed ID: 22960938
    [Abstract] [Full Text] [Related]

  • 8. The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression.
    Martino T, Magalhães FC, Justo GA, Coelho MG, Netto CD, Costa PR, Sabino KC.
    Bioorg Med Chem; 2014 Jun 15; 22(12):3115-22. PubMed ID: 24794748
    [Abstract] [Full Text] [Related]

  • 9. Influence of survivin-targeted therapy on chemosensitivity in the treatment of acute myeloid leukemia.
    Huang J, Lyu H, Wang J, Liu B.
    Cancer Lett; 2015 Oct 01; 366(2):160-72. PubMed ID: 26123662
    [Abstract] [Full Text] [Related]

  • 10. The orally active pterocarpanquinone LQB-118 exhibits cytotoxicity in prostate cancer cell and tumor models through cellular redox stress.
    Martino T, Kudrolli TA, Kumar B, Salviano I, Mencalha A, Coelho MGP, Justo G, Costa PRR, Sabino KCC, Lupold SE.
    Prostate; 2018 Feb 01; 78(2):140-151. PubMed ID: 29105806
    [Abstract] [Full Text] [Related]

  • 11. NFκB pathway and microRNA-9 and -21 are involved in sensitivity to the pterocarpanquinone LQB-118 in different CML cell lines.
    de Faria FC, Leal ME, Bernardo PS, Costa PR, Maia RC.
    Anticancer Agents Med Chem; 2015 Feb 01; 15(3):345-52. PubMed ID: 25964959
    [Abstract] [Full Text] [Related]

  • 12. Targeting survivin with YM155 (Sepantronium Bromide): a novel therapeutic strategy for paediatric acute myeloid leukaemia.
    Smith AM, Little EB, Zivanovic A, Hong P, Liu AK, Burow R, Stinson C, Hallahan AR, Moore AS.
    Leuk Res; 2015 Apr 01; 39(4):435-44. PubMed ID: 25659731
    [Abstract] [Full Text] [Related]

  • 13. siRNA-mediated silencing of survivin inhibits proliferation and enhances etoposide chemosensitivity in acute myeloid leukemia cells.
    Karami H, Baradaran B, Esfahani A, Estiar MA, Naghavi-Behzad M, Sakhinia M, Sakhinia E.
    Asian Pac J Cancer Prev; 2013 Apr 01; 14(12):7719-24. PubMed ID: 24460358
    [Abstract] [Full Text] [Related]

  • 14. LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis.
    Ribeiro GA, Cunha-Júnior EF, Pinheiro RO, da-Silva SA, Canto-Cavalheiro MM, da Silva AJ, Costa PR, Netto CD, Melo RC, Almeida-Amaral EE, Torres-Santos EC.
    J Antimicrob Chemother; 2013 Apr 01; 68(4):789-99. PubMed ID: 23288404
    [Abstract] [Full Text] [Related]

  • 15. siRNA-mediated inhibition of survivin gene enhances the anti-cancer effect of etoposide in U-937 acute myeloid leukemia cells.
    Jafarlou M, Baradaran B, Shanehbandi D, Saedi TA, Jafarlou V, Ismail P, Othman F.
    Cell Mol Biol (Noisy-le-grand); 2016 May 30; 62(6):44-9. PubMed ID: 27262801
    [Abstract] [Full Text] [Related]

  • 16. Anti-inflammatory properties of pterocarpanquinone LQB-118 in mice.
    Riça IG, Netto CD, Rennó MN, Abreu PA, Costa PRR, da Silva AJM, Cavalcante MCM.
    Bioorg Med Chem; 2016 Sep 15; 24(18):4415-4423. PubMed ID: 27492193
    [Abstract] [Full Text] [Related]

  • 17. [Expression of survivin and its location in bone marrow cells of childhood acute leukemia: relationship to therapeutic efficacy].
    Hou Y, Hu Q, Liu AG, Zhang LQ, Liu SY.
    Zhongguo Dang Dai Er Ke Za Zhi; 2006 Apr 15; 8(2):101-4. PubMed ID: 16613699
    [Abstract] [Full Text] [Related]

  • 18. Targeting of X-linked inhibitor of apoptosis protein or survivin by short interfering RNAs sensitize hepatoma cells to TNF-related apoptosis-inducing ligand- and chemotherapeutic agent-induced cell death.
    Yamaguchi Y, Shiraki K, Fuke H, Inoue T, Miyashita K, Yamanaka Y, Saitou Y, Sugimoto K, Nakano T.
    Oncol Rep; 2005 Nov 15; 14(5):1311-6. PubMed ID: 16211302
    [Abstract] [Full Text] [Related]

  • 19. Inhibitors of apoptosis proteins (IAPs) as potential molecular targets for therapy of hematological malignancies.
    Smolewski P, Robak T.
    Curr Mol Med; 2011 Nov 15; 11(8):633-49. PubMed ID: 21902653
    [Abstract] [Full Text] [Related]

  • 20. Preclinical Studies Evaluating Subacute Toxicity and Therapeutic Efficacy of LQB-118 in Experimental Visceral Leishmaniasis.
    Cunha-Júnior EF, Martins TM, Canto-Cavalheiro MM, Marques PR, Portari EA, Coelho MG, Netto CD, Costa PR, Sabino KC, Torres-Santos EC.
    Antimicrob Agents Chemother; 2016 Jun 15; 60(6):3794-801. PubMed ID: 27067332
    [Abstract] [Full Text] [Related]

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