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Journal Abstract Search

293 related items for PubMed ID: 22721924

  • 1. Design, synthesis and antitumor activities of novel bis-aryl ureas derivatives as Raf kinase inhibitors.
    Zhan W, Li Y, Huang W, Zhao Y, Yao Z, Yu S, Yuan S, Jiang F, Yao S, Li S.
    Bioorg Med Chem; 2012 Jul 15; 20(14):4323-9. PubMed ID: 22721924
    [Abstract] [Full Text] [Related]

  • 2. Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells.
    Kim MH, Kim M, Yu H, Kim H, Yoo KH, Sim T, Hah JM.
    Bioorg Med Chem; 2011 Mar 15; 19(6):1915-23. PubMed ID: 21353571
    [Abstract] [Full Text] [Related]

  • 3. Design, synthesis and evaluation of novel diaryl urea derivatives as potential antitumor agents.
    Lu C, Tang K, Li Y, Li P, Lin Z, Yin D, Chen X, Huang H.
    Eur J Med Chem; 2014 Apr 22; 77():351-60. PubMed ID: 24675135
    [Abstract] [Full Text] [Related]

  • 4. Design, synthesis and biological evaluation of bis-aryl ureas and amides based on 2-amino-3-purinylpyridine scaffold as DFG-out B-Raf kinase inhibitors.
    Yang W, Chen Y, Zhou X, Gu Y, Qian W, Zhang F, Han W, Lu T, Tang W.
    Eur J Med Chem; 2015 Jan 07; 89():581-96. PubMed ID: 25462267
    [Abstract] [Full Text] [Related]

  • 5. Design and synthesis of new RAF kinase-inhibiting antiproliferative quinoline derivatives. Part 2: Diarylurea derivatives.
    El-Gamal MI, Khan MA, Tarazi H, Abdel-Maksoud MS, Gamal El-Din MM, Yoo KH, Oh CH.
    Eur J Med Chem; 2017 Feb 15; 127():413-423. PubMed ID: 28088086
    [Abstract] [Full Text] [Related]

  • 6. Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-Raf(V600E) and C-Raf kinase inhibitory activities.
    El-Damasy AK, Lee JH, Seo SH, Cho NC, Pae AN, Keum G.
    Eur J Med Chem; 2016 Jun 10; 115():201-16. PubMed ID: 27017549
    [Abstract] [Full Text] [Related]

  • 7. Design, synthesis, and in vitro antitumor evaluation of novel diaryl ureas derivatives.
    Sun M, Wu X, Chen J, Cai J, Cao M, Ji M.
    Eur J Med Chem; 2010 Jun 10; 45(6):2299-306. PubMed ID: 20181414
    [Abstract] [Full Text] [Related]

  • 8. Design, synthesis and biological activities of thiourea containing sorafenib analogs as antitumor agents.
    Yao J, Chen J, He Z, Sun W, Xu W.
    Bioorg Med Chem; 2012 May 01; 20(9):2923-9. PubMed ID: 22483592
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and antiproliferative activity of novel diaryl ureas possessing a 4H-pyrido[1,2-a]pyrimidin-4-one group.
    Yao P, Zhai X, Liu D, Qi BH, Tan HL, Jin YC, Gong P.
    Arch Pharm (Weinheim); 2010 Jan 01; 343(1):17-23. PubMed ID: 19927308
    [Abstract] [Full Text] [Related]

  • 10. Discovery and initial SAR of pyrimidin-4-yl-1H-imidazole derivatives with antiproliferative activity against melanoma cell lines.
    Lee J, Kim H, Yu H, Chung JY, Oh CH, Yoo KH, Sim T, Hah JM.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1573-7. PubMed ID: 20149658
    [Abstract] [Full Text] [Related]

  • 11. Design and synthesis of orally bioavailable benzimidazoles as Raf kinase inhibitors.
    Ramurthy S, Subramanian S, Aikawa M, Amiri P, Costales A, Dove J, Fong S, Jansen JM, Levine B, Ma S, McBride CM, Michaelian J, Pick T, Poon DJ, Girish S, Shafer CM, Stuart D, Sung L, Renhowe PA.
    J Med Chem; 2008 Nov 27; 51(22):7049-52. PubMed ID: 18942827
    [Abstract] [Full Text] [Related]

  • 12. 1,4-dihydropyrazolo[4,3-d]imidazole phenyl derivatives: a novel type II Raf kinase inhibitors.
    Yu H, Jung Y, Kim H, Lee J, Oh CH, Yoo KH, Sim T, Hah JM.
    Bioorg Med Chem Lett; 2010 Jun 15; 20(12):3805-8. PubMed ID: 20466542
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis and biological activities of sorafenib derivatives as antitumor agents.
    Yao J, He Z, Chen J, Sun W, Fang H, Xu W.
    Bioorg Med Chem Lett; 2012 Nov 01; 22(21):6549-53. PubMed ID: 23021967
    [Abstract] [Full Text] [Related]

  • 14. Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.
    Shallal HM, Russu WA.
    Eur J Med Chem; 2011 Jun 01; 46(6):2043-57. PubMed ID: 21429632
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and evaluation of novel 7-azaindazolyl-indolyl-maleimide derivatives as antitumor agents and protein kinase C inhibitors.
    Ye Q, Cao J, Zhou X, Lv D, He Q, Yang B, Hu Y.
    Bioorg Med Chem; 2009 Jul 01; 17(13):4763-72. PubMed ID: 19447039
    [Abstract] [Full Text] [Related]

  • 16. Design, synthesis, in vitro antiproliferative evaluation, and kinase inhibitory effects of a new series of imidazo[2,1-b]thiazole derivatives.
    Abdel-Maksoud MS, Kim MR, El-Gamal MI, Gamal El-Din MM, Tae J, Choi HS, Lee KT, Yoo KH, Oh CH.
    Eur J Med Chem; 2015 May 05; 95():453-63. PubMed ID: 25841200
    [Abstract] [Full Text] [Related]

  • 17. Design, synthesis and evaluation of novel rhodanine-containing sorafenib analogs as potential antitumor agents.
    Li W, Zhai X, Zhong Z, Li G, Pu Y, Gong P.
    Arch Pharm (Weinheim); 2011 Jun 05; 344(6):349-57. PubMed ID: 21433057
    [Abstract] [Full Text] [Related]

  • 18. Sorafenib derivatives induce apoptosis through inhibition of STAT3 independent of Raf.
    Chen KF, Tai WT, Huang JW, Hsu CY, Chen WL, Cheng AL, Chen PJ, Shiau CW.
    Eur J Med Chem; 2011 Jul 05; 46(7):2845-51. PubMed ID: 21531053
    [Abstract] [Full Text] [Related]

  • 19. Synthesis of amide and urea derivatives of benzothiazole as Raf-1 inhibitor.
    Song EY, Kaur N, Park MY, Jin Y, Lee K, Kim G, Lee KY, Yang JS, Shin JH, Nam KY, No KT, Han G.
    Eur J Med Chem; 2008 Jul 05; 43(7):1519-24. PubMed ID: 18023932
    [Abstract] [Full Text] [Related]

  • 20. Design, synthesis, and antiproliferative activity of 3,4-diarylpyrazole-1-carboxamide derivatives against melanoma cell line.
    El-Gamal MI, Choi HS, Cho HG, Hong JH, Yoo KH, Oh CH.
    Arch Pharm (Weinheim); 2011 Nov 05; 344(11):745-54. PubMed ID: 21954060
    [Abstract] [Full Text] [Related]

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