These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
4. Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2). Min X, Ungureanu D, Maxwell S, Hammarén H, Thibault S, Hillert EK, Ayres M, Greenfield B, Eksterowicz J, Gabel C, Walker N, Silvennoinen O, Wang Z. J Biol Chem; 2015 Nov 06; 290(45):27261-27270. PubMed ID: 26359499 [Abstract] [Full Text] [Related]
5. Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells. Tai Z, Lin Y, He Y, Huang J, Guo J, Yang L, Zhang G, Wang F. Cell Signal; 2014 Mar 06; 26(3):619-28. PubMed ID: 24333668 [Abstract] [Full Text] [Related]
8. Tyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytes. Potla R, Koeck T, Wegrzyn J, Cherukuri S, Shimoda K, Baker DP, Wolfman J, Planchon SM, Esposito C, Hoit B, Dulak J, Wolfman A, Stuehr D, Larner AC. Mol Cell Biol; 2006 Nov 06; 26(22):8562-71. PubMed ID: 16982690 [Abstract] [Full Text] [Related]
9. Novel functions of tyrosine kinase 2 in the antiviral defense against murine cytomegalovirus. Strobl B, Bubic I, Bruns U, Steinborn R, Lajko R, Kolbe T, Karaghiosoff M, Kalinke U, Jonjic S, Müller M. J Immunol; 2005 Sep 15; 175(6):4000-8. PubMed ID: 16148148 [Abstract] [Full Text] [Related]
10. Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunity. Strobl B, Stoiber D, Sexl V, Mueller M. Front Biosci (Landmark Ed); 2011 Jun 01; 16(9):3214-32. PubMed ID: 21622231 [Abstract] [Full Text] [Related]
11. Myxoma virus selectively disrupts type I interferon signaling in primary human fibroblasts by blocking the activation of the Janus kinase Tyk2. Wang F, Barrett JW, Shao Q, Gao X, Dekaban GA, McFadden G. Virology; 2009 Apr 25; 387(1):136-46. PubMed ID: 19254804 [Abstract] [Full Text] [Related]
12. Synthetic Heterodimers of Type III Interferon Receptors Require TYK2 for STAT Activation. Mesev EV, Guare EG, Ploss A, Toettcher JE. J Interferon Cytokine Res; 2023 Sep 25; 43(9):414-426. PubMed ID: 37725008 [Abstract] [Full Text] [Related]
13. Clinical Implications of Targeting the JAK-STAT Pathway in Psoriatic Disease: Emphasis on the TYK2 Pathway. Loo WJ, Turchin I, Prajapati VH, Gooderham MJ, Grewal P, Hong CH, Sauder M, Vender RB, Maari C, Papp KA. J Cutan Med Surg; 2023 Sep 25; 27(1_suppl):3S-24S. PubMed ID: 36519621 [Abstract] [Full Text] [Related]
14. Requirement of catalytically active Tyk2 and accessory signals for the induction of TRAIL mRNA by IFN-beta. Rani MR, Pandalai S, Shrock J, Almasan A, Ransohoff RM. J Interferon Cytokine Res; 2007 Sep 25; 27(9):767-79. PubMed ID: 17892398 [Abstract] [Full Text] [Related]
15. Deucravacitinib is an allosteric TYK2 protein kinase inhibitor FDA-approved for the treatment of psoriasis. Roskoski R. Pharmacol Res; 2023 Mar 25; 189():106642. PubMed ID: 36754102 [Abstract] [Full Text] [Related]
16. Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction. Velazquez L, Mogensen KE, Barbieri G, Fellous M, Uzé G, Pellegrini S. J Biol Chem; 1995 Feb 17; 270(7):3327-34. PubMed ID: 7531704 [Abstract] [Full Text] [Related]
17. Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes. Vogl C, Flatt T, Fuhrmann B, Hofmann E, Wallner B, Stiefvater R, Kovarik P, Strobl B, Müller M. BMC Genomics; 2010 Mar 25; 11():199. PubMed ID: 20338026 [Abstract] [Full Text] [Related]
18. Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway. Stancato LF, Sakatsume M, David M, Dent P, Dong F, Petricoin EF, Krolewski JJ, Silvennoinen O, Saharinen P, Pierce J, Marshall CJ, Sturgill T, Finbloom DS, Larner AC. Mol Cell Biol; 1997 Jul 25; 17(7):3833-40. PubMed ID: 9199317 [Abstract] [Full Text] [Related]
19. Activation of the protein tyrosine kinase tyk2 by interferon alpha/beta. Barbieri G, Velazquez L, Scrobogna M, Fellous M, Pellegrini S. Eur J Biochem; 1994 Jul 15; 223(2):427-35. PubMed ID: 8055912 [Abstract] [Full Text] [Related]
20. A novel highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) can block inflammation- and autoimmune-related pathways. Chen CX, Zhang W, Qu S, Xia F, Zhu Y, Chen B. Cell Commun Signal; 2023 Oct 16; 21(1):287. PubMed ID: 37845748 [Abstract] [Full Text] [Related] Page: [Next] [New Search]