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Journal Abstract Search

349 related items for PubMed ID: 22738316

  • 1. Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
    Lacivita E, Patarnello D, Stroth N, Caroli A, Niso M, Contino M, De Giorgio P, Di Pilato P, Colabufo NA, Berardi F, Perrone R, Svenningsson P, Hedlund PB, Leopoldo M.
    J Med Chem; 2012 Jul 26; 55(14):6375-80. PubMed ID: 22738316
    [Abstract] [Full Text] [Related]

  • 2. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
    Leopoldo M, Berardi F, Colabufo NA, Contino M, Lacivita E, Niso M, Perrone R, Tortorella V.
    J Med Chem; 2004 Dec 16; 47(26):6616-24. PubMed ID: 15588097
    [Abstract] [Full Text] [Related]

  • 3. 1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics.
    Bojarski AJ, Paluchowska MH, Duszyńska B, Kłodzińska A, Tatarczyńska E, Chojnacka-Wójcik E.
    Bioorg Med Chem; 2005 Mar 15; 13(6):2293-303. PubMed ID: 15727878
    [Abstract] [Full Text] [Related]

  • 4. Effect of several 5-hydroxytryptamine(1A) receptor ligands on the micturition reflex in rats: comparison with WAY 100635.
    Testa R, Guarneri L, Poggesi E, Angelico P, Velasco C, Ibba M, Cilia A, Motta G, Riva C, Leonardi A.
    J Pharmacol Exp Ther; 1999 Sep 15; 290(3):1258-69. PubMed ID: 10454502
    [Abstract] [Full Text] [Related]

  • 5. Synthesis by microwave irradiation and binding properties of novel 5-HT(1A) receptor ligands.
    Caliendo G, Fiorino F, Perissutti E, Severino B, Gessi S, Cattabriga E, Borea PA, Santagada V.
    Eur J Med Chem; 2001 Sep 15; 36(11-12):873-86. PubMed ID: 11755230
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635.
    Mensonides-Harsema MM, Liao Y, Böttcher H, Bartoszyk GD, Greiner HE, Harting J, de Boer P, Wikström HV.
    J Med Chem; 2000 Feb 10; 43(3):432-9. PubMed ID: 10669570
    [Abstract] [Full Text] [Related]

  • 7. Improvement in the selectivity and metabolic stability of the serotonin 5-HT(1A) ligand, S 15535: a series of cis- and trans-2-(arylcycloalkylamine) 1-indanols.
    Peglion JL, Goument B, Despaux N, Charlot V, Giraud H, Nisole C, Newman-Tancredi A, Dekeyne A, Bertrand M, Genissel P, Millan MJ.
    J Med Chem; 2002 Jan 03; 45(1):165-76. PubMed ID: 11754589
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and structure-activity relationships of a new model of arylpiperazines. Study of the 5-HT(1a)/alpha(1)-adrenergic receptor affinity by classical hansch analysis, artificial neural networks, and computational simulation of ligand recognition.
    López-Rodríguez ML, Morcillo MJ, Fernández E, Rosado ML, Pardo L, Schaper K.
    J Med Chem; 2001 Jan 18; 44(2):198-207. PubMed ID: 11170629
    [Abstract] [Full Text] [Related]

  • 9. WB 4101-related compounds. 2. Role of the ethylene chain separating amine and phenoxy units on the affinity for alpha(1)-adrenoreceptor subtypes and 5-HT(1A) receptors.
    Bolognesi ML, Budriesi R, Cavalli A, Chiarini A, Gotti R, Leonardi A, Minarini A, Poggesi E, Recanatini M, Rosini M, Tumiatti V, Melchiorre C.
    J Med Chem; 1999 Oct 07; 42(20):4214-24. PubMed ID: 10514291
    [Abstract] [Full Text] [Related]

  • 10. 2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxamides with selective affinity for the 5-HT(4) receptor: synthesis and structure-affinity and structure-activity relationships of a new series of partial agonist and antagonist derivatives.
    Tapia I, Alonso-Cires L, López-Tudanca PL, Mosquera R, Labeaga L, Innerárity A, Orjales A.
    J Med Chem; 1999 Jul 29; 42(15):2870-80. PubMed ID: 10425096
    [Abstract] [Full Text] [Related]

  • 11. Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor.
    Kim Y, Kim J, Tae J, Roth BL, Rhim H, Keum G, Nam G, Choo H.
    Bioorg Med Chem; 2013 May 01; 21(9):2568-76. PubMed ID: 23541835
    [Abstract] [Full Text] [Related]

  • 12. The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.
    Gaster LM, Blaney FE, Davies S, Duckworth DM, Ham P, Jenkins S, Jennings AJ, Joiner GF, King FD, Mulholland KR, Wyman PA, Hagan JJ, Hatcher J, Jones BJ, Middlemiss DN, Price GW, Riley G, Roberts C, Routledge C, Selkirk J, Slade PD.
    J Med Chem; 1998 Apr 09; 41(8):1218-35. PubMed ID: 9548813
    [Abstract] [Full Text] [Related]

  • 13. New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.
    Jurczyk S, Kołaczkowski M, Maryniak E, Zajdel P, Pawłowski M, Tatarczyńska E, Kłodzińska A, Chojnacka-Wójcik E, Bojarski AJ, Charakchieva-Minol S, Duszyńska B, Nowak G, Maciag D.
    J Med Chem; 2004 May 06; 47(10):2659-66. PubMed ID: 15115407
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT(1a)/alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed 5-HT(1a)/d(2) antagonist properties.
    López-Rodríguez ML, Morcillo MJ, Fernández E, Porras E, Orensanz L, Beneytez ME, Manzanares J, Fuentes JA.
    J Med Chem; 2001 Jan 18; 44(2):186-97. PubMed ID: 11170628
    [Abstract] [Full Text] [Related]

  • 15. New 5-hydroxytryptamine(1A) receptor ligands containing a norbornene nucleus: synthesis and in vitro pharmacological evaluation.
    Fiorino F, Perissutti E, Severino B, Santagada V, Cirillo D, Terracciano S, Massarelli P, Bruni G, Collavoli E, Renner C, Caliendo G.
    J Med Chem; 2005 Aug 25; 48(17):5495-503. PubMed ID: 16107148
    [Abstract] [Full Text] [Related]

  • 16. trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines.
    Perrone R, Berardi F, Colabufo NA, Leopoldo M, Lacivita E, Tortorella V, Leonardi A, Poggesi E, Testa R.
    J Med Chem; 2001 Dec 06; 44(25):4431-42. PubMed ID: 11728188
    [Abstract] [Full Text] [Related]

  • 17. Active conformation of some arylpiperazine postsynaptic 5-HT(1A) receptor antagonists.
    Paluchowska MH, Bojarski AJ, Charakchieva-Minol S, Wesołowska A.
    Eur J Med Chem; 2002 Apr 06; 37(4):273-83. PubMed ID: 11960662
    [Abstract] [Full Text] [Related]

  • 18. Optimization of (arylpiperazinylbutyl)oxindoles exhibiting selective 5-HT₇ receptor antagonist activity.
    Volk B, Gacsályi I, Pallagi K, Poszávácz L, Gyönös I, Szabó E, Bakó T, Spedding M, Simig G, Szénási G.
    J Med Chem; 2011 Oct 13; 54(19):6657-69. PubMed ID: 21859099
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.
    Perrone R, Berardi F, Colabufo NA, Lacivita E, Leopoldo M, Tortorella V.
    J Med Chem; 2003 Feb 13; 46(4):646-9. PubMed ID: 12570387
    [Abstract] [Full Text] [Related]

  • 20. A synthetic overview of new molecules with 5-HT1A binding affinities.
    Pessoa-Mahana H, Araya-Maturana R, Saitz CB, Pessoa-Mahana DC.
    Mini Rev Med Chem; 2003 Mar 13; 3(2):77-93. PubMed ID: 12570842
    [Abstract] [Full Text] [Related]

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