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Journal Abstract Search

349 related items for PubMed ID: 22738316

  • 21. Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.
    Cappelli A, Anzini M, Vomero S, Canullo L, Mennuni L, Makovec F, Doucet E, Hamon M, Menziani MC, De Benedetti PG, Bruni G, Romeo MR, Giorgi G, Donati A.
    J Med Chem; 1999 May 06; 42(9):1556-75. PubMed ID: 10229626
    [Abstract] [Full Text] [Related]

  • 22. 5-HT1B receptor antagonist properties of novel arylpiperazide derivatives of 1-naphthylpiperazine.
    Jorand-Lebrun C, Pauwels PJ, Palmier C, Moret C, Chopin P, Perez M, Marien M, Halazy S.
    J Med Chem; 1997 Nov 21; 40(24):3974-8. PubMed ID: 9397179
    [Abstract] [Full Text] [Related]

  • 23. Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.
    Campiani G, Morelli E, Gemma S, Nacci V, Butini S, Hamon M, Novellino E, Greco G, Cagnotto A, Goegan M, Cervo L, Dalla Valle F, Fracasso C, Caccia S, Mennini T.
    J Med Chem; 1999 Oct 21; 42(21):4362-79. PubMed ID: 10543880
    [Abstract] [Full Text] [Related]

  • 24. Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic α₁- and serotonine 5-HT1A receptors.
    Prandi A, Franchini S, Manasieva LI, Fossa P, Cichero E, Marucci G, Buccioni M, Cilia A, Pirona L, Brasili L.
    J Med Chem; 2012 Jan 12; 55(1):23-36. PubMed ID: 22145629
    [Abstract] [Full Text] [Related]

  • 25. Modification of the structure of 4, 6-disubstituted 2-(4-alkyl-1-piperazinyl)pyridines: synthesis and their 5-HT2A receptor activity.
    Paluchowska MH, Bojarski AJ, Bugno R, Charakchieva-Minol S, Wesołowska A.
    Arch Pharm (Weinheim); 2003 Apr 12; 336(2):104-10. PubMed ID: 12761763
    [Abstract] [Full Text] [Related]

  • 26. New selective and potent 5-HT(1B/1D) antagonists: chemistry and pharmacological evaluation of N-piperazinylphenyl biphenylcarboxamides and biphenylsulfonamides.
    Liao Y, Böttcher H, Harting J, Greiner H, van Amsterdam C, Cremers T, Sundell S, März J, Rautenberg W, Wikström H.
    J Med Chem; 2000 Feb 10; 43(3):517-25. PubMed ID: 10669578
    [Abstract] [Full Text] [Related]

  • 27. Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: synthesis and binding affinities for 5-HT(7) and 5-HT(1A) receptors.
    Leopoldo M, Lacivita E, Colabufo NA, Niso M, Berardi F, Perrone R.
    Bioorg Med Chem; 2007 Aug 01; 15(15):5316-21. PubMed ID: 17517509
    [Abstract] [Full Text] [Related]

  • 28. Aryl biphenyl-3-ylmethylpiperazines as 5-HT7 receptor antagonists.
    Kim J, Kim Y, Tae J, Yeom M, Moon B, Huang XP, Roth BL, Lee K, Rhim H, Choo IH, Chong Y, Keum G, Nam G, Choo H.
    ChemMedChem; 2013 Nov 01; 8(11):1855-64. PubMed ID: 24039134
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  • 31. 1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors.
    Sabb AL, Vogel RL, Kelly MG, Palmer Y, Smith DL, Andree TH, Schechter LE.
    Bioorg Med Chem Lett; 2001 Apr 23; 11(8):1069-71. PubMed ID: 11327592
    [Abstract] [Full Text] [Related]

  • 32. S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization.
    Millan MJ, Mannoury la Cour C, Chanrion B, Dupuis DS, Di Cara B, Audinot V, Cussac D, Newman-Tancredi A, Kamal M, Boutin JA, Jockers R, Marin P, Bockaert J, Muller O, Dekeyne A, Lavielle G.
    J Pharmacol Exp Ther; 2012 Mar 23; 340(3):750-64. PubMed ID: 22178752
    [Abstract] [Full Text] [Related]

  • 33. Arylpiperazine derivatives acting at 5-HT(1A) receptors.
    López-Rodríguez ML, Ayala D, Benhamú B, Morcillo MJ, Viso A.
    Curr Med Chem; 2002 Feb 23; 9(4):443-69. PubMed ID: 11945120
    [Abstract] [Full Text] [Related]

  • 34. Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.
    Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML.
    J Med Chem; 2009 Apr 23; 52(8):2384-92. PubMed ID: 19326916
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  • 36. Synthesis and evaluation of 1-[2-(4-[(11)C]methoxyphenyl)phenyl]piperazine for imaging of the serotonin 5-HT7 receptor in the rat brain.
    Shimoda Y, Yui J, Xie L, Fujinaga M, Yamasaki T, Ogawa M, Nengaki N, Kumata K, Hatori A, Kawamura K, Zhang MR.
    Bioorg Med Chem; 2013 Sep 01; 21(17):5316-22. PubMed ID: 23830697
    [Abstract] [Full Text] [Related]

  • 37. Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.
    Delgado M, Caicoya AG, Greciano V, Benhamú B, López-Rodríguez ML, Fernández-Alfonso MS, Pozo MA, Manzanares J, Fuentes JA.
    Eur J Pharmacol; 2005 Mar 21; 511(1):9-19. PubMed ID: 15777774
    [Abstract] [Full Text] [Related]

  • 38. Alpha1-adrenoceptor antagonists. 6. Structural optimization of pyridazinone-arylpiperazines. Study of the influence on affinity and selectivity of cyclic substituents at the pyridazinone ring and alkoxy groups at the arylpiperazine moiety.
    Betti L, Corelli F, Floridi M, Giannaccini G, Maccari L, Manetti F, Strappaghetti G, Botta M.
    J Med Chem; 2003 Jul 31; 46(16):3555-8. PubMed ID: 12877594
    [Abstract] [Full Text] [Related]

  • 39. [N-methyl-3H3]AZ10419369 binding to the 5-HT1B receptor: in vitro characterization and in vivo receptor occupancy.
    Maier DL, Sobotka-Briner C, Ding M, Powell ME, Jiang Q, Hill G, Heys JR, Elmore CS, Pierson ME, Mrzljak L.
    J Pharmacol Exp Ther; 2009 Jul 31; 330(1):342-51. PubMed ID: 19401496
    [Abstract] [Full Text] [Related]

  • 40. 1,3-Dioxolane-based ligands as rigid analogues of naftopidil: structure-affinity/activity relationships at alpha1 and 5-HT1A receptors.
    Sorbi C, Franchini S, Tait A, Prandi A, Gallesi R, Angeli P, Marucci G, Pirona L, Poggesi E, Brasili L.
    ChemMedChem; 2009 Mar 31; 4(3):393-9. PubMed ID: 19152363
    [Abstract] [Full Text] [Related]

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