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291 related items for PubMed ID: 22761416

  • 21. Structure of the HIV-1 reverse transcriptase Q151M mutant: insights into the inhibitor resistance of HIV-1 reverse transcriptase and the structure of the nucleotide-binding pocket of Hepatitis B virus polymerase.
    Nakamura A, Tamura N, Yasutake Y.
    Acta Crystallogr F Struct Biol Commun; 2015 Nov; 71(Pt 11):1384-90. PubMed ID: 26527265
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  • 22. Molecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutations.
    Vijayan RS, Arnold E, Das K.
    Proteins; 2014 May; 82(5):815-29. PubMed ID: 24174331
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  • 23. Impact of unreported HIV-1 reverse transcriptase mutations on phenotypic resistance to nucleoside and non-nucleoside inhibitors.
    Saracino A, Monno L, Scudeller L, Cibelli DC, Tartaglia A, Punzi G, Torti C, Lo Caputo S, Mazzotta F, Scotto G, Carosi G, Angarano G.
    J Med Virol; 2006 Jan; 78(1):9-17. PubMed ID: 16299731
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  • 24. Effect of a bound non-nucleoside RT inhibitor on the dynamics of wild-type and mutant HIV-1 reverse transcriptase.
    Zhou Z, Madrid M, Evanseck JD, Madura JD.
    J Am Chem Soc; 2005 Dec 14; 127(49):17253-60. PubMed ID: 16332074
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  • 25. Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
    Ren J, Milton J, Weaver KL, Short SA, Stuart DI, Stammers DK.
    Structure; 2000 Oct 15; 8(10):1089-94. PubMed ID: 11080630
    [Abstract] [Full Text] [Related]

  • 26. Characterization and structural analysis of novel mutations in human immunodeficiency virus type 1 reverse transcriptase involved in the regulation of resistance to nonnucleoside inhibitors.
    Ceccherini-Silberstein F, Svicher V, Sing T, Artese A, Santoro MM, Forbici F, Bertoli A, Alcaro S, Palamara G, d'Arminio Monforte A, Balzarini J, Antinori A, Lengauer T, Perno CF.
    J Virol; 2007 Oct 15; 81(20):11507-19. PubMed ID: 17686836
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  • 27. Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision.
    Boyer PL, Imamichi T, Sarafianos SG, Arnold E, Hughes SH.
    J Virol; 2004 Sep 15; 78(18):9987-97. PubMed ID: 15331732
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  • 28. Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1.
    Balzarini J.
    Curr Top Med Chem; 2004 Sep 15; 4(9):921-44. PubMed ID: 15134549
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  • 29. N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation.
    Biondi MJ, Beilhartz GL, McCormick S, Götte M.
    J Biol Chem; 2010 Aug 27; 285(35):26966-26975. PubMed ID: 20530477
    [Abstract] [Full Text] [Related]

  • 30. Mutational patterns in the HIV genome and cross-resistance following nucleoside and nucleotide analogue drug exposure.
    Miller V, Larder BA.
    Antivir Ther; 2001 Aug 27; 6 Suppl 3():25-44. PubMed ID: 11678471
    [Abstract] [Full Text] [Related]

  • 31. Structural basis for drug resistance mechanisms for non-nucleoside inhibitors of HIV reverse transcriptase.
    Ren J, Stammers DK.
    Virus Res; 2008 Jun 27; 134(1-2):157-70. PubMed ID: 18313784
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  • 32. A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors.
    Nikolenko GN, Delviks-Frankenberry KA, Pathak VK.
    J Virol; 2010 May 27; 84(10):5238-49. PubMed ID: 20219933
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  • 33. Structural basis of HIV-1 resistance to AZT by excision.
    Tu X, Das K, Han Q, Bauman JD, Clark AD, Hou X, Frenkel YV, Gaffney BL, Jones RA, Boyer PL, Hughes SH, Sarafianos SG, Arnold E.
    Nat Struct Mol Biol; 2010 Oct 27; 17(10):1202-9. PubMed ID: 20852643
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  • 34. The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations.
    Miranda LR, Götte M, Liang F, Kuritzkes DR.
    Antimicrob Agents Chemother; 2005 Jul 27; 49(7):2648-56. PubMed ID: 15980332
    [Abstract] [Full Text] [Related]

  • 35. Novel nonnucleoside inhibitors that select nucleoside inhibitor resistance mutations in human immunodeficiency virus type 1 reverse transcriptase.
    Zhang Z, Walker M, Xu W, Shim JH, Girardet JL, Hamatake RK, Hong Z.
    Antimicrob Agents Chemother; 2006 Aug 27; 50(8):2772-81. PubMed ID: 16870771
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  • 36. Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant.
    Das K, Ding J, Hsiou Y, Clark AD, Moereels H, Koymans L, Andries K, Pauwels R, Janssen PA, Boyer PL, Clark P, Smith RH, Kroeger Smith MB, Michejda CJ, Hughes SH, Arnold E.
    J Mol Biol; 1996 Dec 20; 264(5):1085-100. PubMed ID: 9000632
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  • 37. HIV-1 reverse transcriptase and antiviral drug resistance. Part 1.
    Das K, Arnold E.
    Curr Opin Virol; 2013 Apr 20; 3(2):111-8. PubMed ID: 23602471
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  • 38. Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.
    Matamoros T, Nevot M, Martínez MA, Menéndez-Arias L.
    J Biol Chem; 2009 Nov 20; 284(47):32792-802. PubMed ID: 19801659
    [Abstract] [Full Text] [Related]

  • 39. Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 1.
    Hopkins AL, Ren J, Milton J, Hazen RJ, Chan JH, Stuart DI, Stammers DK.
    J Med Chem; 2004 Nov 18; 47(24):5912-22. PubMed ID: 15537346
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  • 40. Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities.
    Shaw-Reid CA, Feuston B, Munshi V, Getty K, Krueger J, Hazuda DJ, Parniak MA, Miller MD, Lewis D.
    Biochemistry; 2005 Feb 08; 44(5):1595-606. PubMed ID: 15683243
    [Abstract] [Full Text] [Related]

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