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Journal Abstract Search

306 related items for PubMed ID: 22778836

  • 21. Predicting efflux ratios and blood-brain barrier penetration from chemical structure: combining passive permeability with active efflux by P-glycoprotein.
    Dolghih E, Jacobson MP.
    ACS Chem Neurosci; 2013 Feb 20; 4(2):361-7. PubMed ID: 23421687
    [Abstract] [Full Text] [Related]

  • 22. CNS drug design: balancing physicochemical properties for optimal brain exposure.
    Rankovic Z.
    J Med Chem; 2015 Mar 26; 58(6):2584-608. PubMed ID: 25494650
    [Abstract] [Full Text] [Related]

  • 23. Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy.
    Miller DS, Bauer B, Hartz AM.
    Pharmacol Rev; 2008 Jun 26; 60(2):196-209. PubMed ID: 18560012
    [Abstract] [Full Text] [Related]

  • 24. Successful Prediction of Human Steady-State Unbound Brain-to-Plasma Concentration Ratio of P-gp Substrates Using the Proteomics-Informed Relative Expression Factor Approach.
    Storelli F, Anoshchenko O, Unadkat JD.
    Clin Pharmacol Ther; 2021 Aug 26; 110(2):432-442. PubMed ID: 33675056
    [Abstract] [Full Text] [Related]

  • 25. Evaluating the Utility of Canine Mdr1 Knockout Madin-Darby Canine Kidney I Cells in Permeability Screening and Efflux Substrate Determination.
    Chen EC, Broccatelli F, Plise E, Chen B, Liu L, Cheong J, Zhang S, Jorski J, Gaffney K, Umemoto KK, Salphati L.
    Mol Pharm; 2018 Nov 05; 15(11):5103-5113. PubMed ID: 30222362
    [Abstract] [Full Text] [Related]

  • 26. Occurrence of Morpholine in Central Nervous System Drug Discovery.
    Lenci E, Calugi L, Trabocchi A.
    ACS Chem Neurosci; 2021 Feb 03; 12(3):378-390. PubMed ID: 33459557
    [Abstract] [Full Text] [Related]

  • 27. Development of Simplified in Vitro P-Glycoprotein Substrate Assay and in Silico Prediction Models To Evaluate Transport Potential of P-Glycoprotein.
    Ohashi R, Watanabe R, Esaki T, Taniguchi T, Torimoto-Katori N, Watanabe T, Ogasawara Y, Takahashi T, Tsukimoto M, Mizuguchi K.
    Mol Pharm; 2019 May 06; 16(5):1851-1863. PubMed ID: 30933526
    [Abstract] [Full Text] [Related]

  • 28. The Blood-Brain Barrier (BBB) Score.
    Gupta M, Lee HJ, Barden CJ, Weaver DF.
    J Med Chem; 2019 Nov 14; 62(21):9824-9836. PubMed ID: 31603678
    [Abstract] [Full Text] [Related]

  • 29. Assessment of the classification abilities of the CNS multi-parametric optimization approach by the method of logistic regression.
    Raevsky OA, Polianczyk DE, Mukhametov A, Grigorev VY.
    SAR QSAR Environ Res; 2016 Aug 14; 27(8):629-35. PubMed ID: 27477321
    [Abstract] [Full Text] [Related]

  • 30. Exclusion of unsuitable CNS drug candidates based on their physicochemical properties and unbound fractions in biomatrices for brain microdialysis investigations.
    Wang Q, Ren T, Zhao J, Wong CH, Chan HYE, Zuo Z.
    J Pharm Biomed Anal; 2020 Jan 30; 178():112946. PubMed ID: 31727358
    [Abstract] [Full Text] [Related]

  • 31. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model.
    Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E, Chen C, Chen X, Choo E, Cianfrogna J, Cox LM, Gibbs JP, Gibbs MA, Hatch H, Hop CE, Kasman IN, Laperle J, Liu J, Liu X, Logman M, Maclin D, Nedza FM, Nelson F, Olson E, Rahematpura S, Raunig D, Rogers S, Schmidt K, Spracklin DK, Szewc M, Troutman M, Tseng E, Tu M, Van Deusen JW, Venkatakrishnan K, Walens G, Wang EQ, Wong D, Yasgar AS, Zhang C.
    Drug Metab Dispos; 2005 Jan 30; 33(1):165-74. PubMed ID: 15502009
    [Abstract] [Full Text] [Related]

  • 32. High-throughput hydrogen bond strength calculation and its applications in optimizing drug ADME properties.
    Shen J, Yang Y, Broughton H, Watson IA, Desai PV.
    Future Med Chem; 2019 Mar 30; 11(6):511-524. PubMed ID: 30892942
    [Abstract] [Full Text] [Related]

  • 33. Practical approaches to evaluating and optimizing brain exposure in early drug discovery.
    Freeman BB, Yang L, Rankovic Z.
    Eur J Med Chem; 2019 Nov 15; 182():111643. PubMed ID: 31514017
    [Abstract] [Full Text] [Related]

  • 34. Challenges in the search for drugs to treat central nervous system disorders.
    Enna SJ, Williams M.
    J Pharmacol Exp Ther; 2009 May 15; 329(2):404-11. PubMed ID: 19182069
    [Abstract] [Full Text] [Related]

  • 35.
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  • 36. Methods to optimize CNS exposure of drug candidates.
    Patel NC.
    Bioorg Med Chem Lett; 2020 Dec 01; 30(23):127503. PubMed ID: 32853684
    [Abstract] [Full Text] [Related]

  • 37. [Lead compound optimization strategy (4)--improving blood-brain barrier permeability through structural modification].
    Hong Y, Zhou Y, Wang J, Liu H.
    Yao Xue Xue Bao; 2014 Jun 01; 49(6):789-99. PubMed ID: 25212022
    [Abstract] [Full Text] [Related]

  • 38. Hydrophobicity and central nervous system agents: on the principle of minimal hydrophobicity in drug design.
    Hansch C, Björkroth JP, Leo A.
    J Pharm Sci; 1987 Sep 01; 76(9):663-87. PubMed ID: 11002801
    [Abstract] [Full Text] [Related]

  • 39. Essentials and Perspectives of Computational Modelling Assistance for CNS-oriented Nanoparticle-based Drug Delivery Systems.
    Kisała J, Hęclik KI, Pogocki K, Pogocki D.
    Curr Med Chem; 2018 Sep 01; 25(42):5894-5913. PubMed ID: 29768999
    [Abstract] [Full Text] [Related]

  • 40. Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.
    Storer RI, Brennan PE, Brown AD, Bungay PJ, Conlon KM, Corbett MS, DePianta RP, Fish PV, Heifetz A, Ho DK, Jessiman AS, McMurray G, de Oliveira CA, Roberts LR, Root JA, Shanmugasundaram V, Shapiro MJ, Skerten M, Westbrook D, Wheeler S, Whitlock GA, Wright J.
    J Med Chem; 2014 Jun 26; 57(12):5258-69. PubMed ID: 24878222
    [Abstract] [Full Text] [Related]

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