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Journal Abstract Search

202 related items for PubMed ID: 22830422

  • 1. Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model.
    Tsunoda T, Ota T, Fujimoto T, Doi K, Tanaka Y, Yoshida Y, Ogawa M, Matsuzaki H, Hamabashiri M, Tyson DR, Kuroki M, Miyamoto S, Shirasawa S.
    Mol Cancer; 2012 Jul 25; 11():46. PubMed ID: 22830422
    [Abstract] [Full Text] [Related]

  • 2. Phosphodiesterase 4B is an effective therapeutic target in colorectal cancer.
    Kim DU, Kwak B, Kim SW.
    Biochem Biophys Res Commun; 2019 Jan 15; 508(3):825-831. PubMed ID: 30528730
    [Abstract] [Full Text] [Related]

  • 3. Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant KRAS.
    Nishi K, Luo H, Ishikura S, Doi K, Iwaihara Y, Wills L, Baillie GS, Sakata T, Shirasawa S, Tsunoda T.
    Anticancer Res; 2017 Jul 15; 37(7):3833-3839. PubMed ID: 28668883
    [Abstract] [Full Text] [Related]

  • 4. ALPK2 is crucial for luminal apoptosis and DNA repair-related gene expression in a three-dimensional colonic-crypt model.
    Yoshida Y, Tsunoda T, Doi K, Fujimoto T, Tanaka Y, Ota T, Ogawa M, Matsuzaki H, Kuroki M, Iwasaki A, Shirasawa S.
    Anticancer Res; 2012 Jun 15; 32(6):2301-8. PubMed ID: 22641666
    [Abstract] [Full Text] [Related]

  • 5. Inhibition of PDE4/PDE4B improves renal function and ameliorates inflammation in cisplatin-induced acute kidney injury.
    Xu M, Yu X, Meng X, Huang S, Zhang Y, Zhang A, Jia Z.
    Am J Physiol Renal Physiol; 2020 Mar 01; 318(3):F576-F588. PubMed ID: 31961716
    [Abstract] [Full Text] [Related]

  • 6. Phosphodiesterase-4 inhibition confers a neuroprotective efficacy against early brain injury following experimental subarachnoid hemorrhage in rats by attenuating neuronal apoptosis through the SIRT1/Akt pathway.
    Li Q, Peng Y, Fan L, Xu H, He P, Cao S, Li J, Chen T, Ruan W, Chen G.
    Biomed Pharmacother; 2018 Mar 01; 99():947-955. PubMed ID: 29710495
    [Abstract] [Full Text] [Related]

  • 7. The unrecognized effects of phosphodiesterase 4 on epithelial cells in pulmonary inflammation.
    Konrad FM, Bury A, Schick MA, Ngamsri KC, Reutershan J.
    PLoS One; 2015 Mar 01; 10(4):e0121725. PubMed ID: 25909327
    [Abstract] [Full Text] [Related]

  • 8. Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.
    Yang JX, Hsieh KC, Chen YL, Lee CK, Conti M, Chuang TH, Wu CP, Jin SC.
    Sci Rep; 2017 Apr 06; 7():46165. PubMed ID: 28383060
    [Abstract] [Full Text] [Related]

  • 9. Resveratrol induces luminal apoptosis of human colorectal cancer HCT116 cells in three-dimensional culture.
    Tsunoda T, Ishikura S, Doi K, Matsuzaki H, Iwaihara Y, Shirasawa S.
    Anticancer Res; 2014 Aug 06; 34(8):4551-5. PubMed ID: 25075098
    [Abstract] [Full Text] [Related]

  • 10. Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation.
    Avila DV, Myers SA, Zhang J, Kharebava G, McClain CJ, Kim HY, Whittemore SR, Gobejishvili L, Barve S.
    Neuropharmacology; 2017 Oct 06; 125():376-385. PubMed ID: 28807677
    [Abstract] [Full Text] [Related]

  • 11. Three-dimensionally specific inhibition of DNA repair-related genes by activated KRAS in colon crypt model.
    Tsunoda T, Takashima Y, Fujimoto T, Koyanagi M, Yoshida Y, Doi K, Tanaka Y, Kuroki M, Sasazuki T, Shirasawa S.
    Neoplasia; 2010 May 06; 12(5):397-404. PubMed ID: 20454511
    [Abstract] [Full Text] [Related]

  • 12. Oncogenic KRAS regulates miR-200c and miR-221/222 in a 3D-specific manner in colorectal cancer cells.
    Tsunoda T, Takashima Y, Yoshida Y, Doi K, Tanaka Y, Fujimoto T, Machida T, Ota T, Koyanagi M, Kuroki M, Sasazuki T, Shirasawa S.
    Anticancer Res; 2011 Jul 06; 31(7):2453-9. PubMed ID: 21873159
    [Abstract] [Full Text] [Related]

  • 13. PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas.
    Klein CH, Truxius DC, Vogel HA, Harizanova J, Murarka S, Martín-Gago P, Bastiaens PIH.
    Int J Cancer; 2019 Feb 15; 144(4):767-776. PubMed ID: 30194764
    [Abstract] [Full Text] [Related]

  • 14. Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis.
    Avila DV, Barker DF, Zhang J, McClain CJ, Barve S, Gobejishvili L.
    J Pathol; 2016 Sep 15; 240(1):96-107. PubMed ID: 27287961
    [Abstract] [Full Text] [Related]

  • 15. A phosphodiesterase 4B-dependent interplay between tumor cells and the microenvironment regulates angiogenesis in B-cell lymphoma.
    Suhasini AN, Wang L, Holder KN, Lin AP, Bhatnagar H, Kim SW, Moritz AW, Aguiar RCT.
    Leukemia; 2016 Mar 15; 30(3):617-626. PubMed ID: 26503641
    [Abstract] [Full Text] [Related]

  • 16. Gene set enrichment analysis unveils the mechanism for the phosphodiesterase 4B control of glucocorticoid response in B-cell lymphoma.
    Kim SW, Rai D, Aguiar RC.
    Clin Cancer Res; 2011 Nov 01; 17(21):6723-32. PubMed ID: 21742807
    [Abstract] [Full Text] [Related]

  • 17. The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma.
    Smith PG, Wang F, Wilkinson KN, Savage KJ, Klein U, Neuberg DS, Bollag G, Shipp MA, Aguiar RC.
    Blood; 2005 Jan 01; 105(1):308-16. PubMed ID: 15331441
    [Abstract] [Full Text] [Related]

  • 18. 4-Acetyl-Antroquinonol B Improves the Sensitization of Cetuximab on Both Kras Mutant and Wild Type Colorectal Cancer by Modulating the Expression of Ras/Raf/miR-193a-3p Signaling Axis.
    Chu YC, Tsai TY, Yadav VK, Deng L, Huang CC, Tzeng YM, Yeh CT, Chen MY.
    Int J Mol Sci; 2021 Jul 14; 22(14):. PubMed ID: 34299137
    [Abstract] [Full Text] [Related]

  • 19. Long noncoding RNA SNHG14 accelerates cell proliferation, migration, invasion and suppresses apoptosis in colorectal cancer cells by targeting miR-944/KRAS axis through PI3K/AKT pathway.
    Pei Q, Liu GS, Li HP, Zhang Y, Xu XC, Gao H, Zhang W, Li T.
    Eur Rev Med Pharmacol Sci; 2019 Nov 14; 23(22):9871-9881. PubMed ID: 31799655
    [Abstract] [Full Text] [Related]

  • 20. miR-450b-5p induced by oncogenic KRAS is required for colorectal cancer progression.
    Ye YP, Wu P, Gu CC, Deng DL, Jiao HL, Li TT, Wang SY, Wang YX, Xiao ZY, Wei WT, Chen YR, Qiu JF, Yang RW, Lin J, Liang L, Liao WT, Ding YQ.
    Oncotarget; 2016 Sep 20; 7(38):61312-61324. PubMed ID: 27494869
    [Abstract] [Full Text] [Related]

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