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286 related items for PubMed ID: 22846914

  • 1. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
    Patel RA, Forinash KD, Pireddu R, Sun Y, Sun N, Martin MP, Schönbrunn E, Lawrence NJ, Sebti SM.
    Cancer Res; 2012 Oct 01; 72(19):5025-34. PubMed ID: 22846914
    [Abstract] [Full Text] [Related]

  • 2. Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities.
    Patel RA, Liu Y, Wang B, Li R, Sebti SM.
    Oncogene; 2014 Jan 30; 33(5):550-5. PubMed ID: 23396364
    [Abstract] [Full Text] [Related]

  • 3. RKI-1447 suppresses colorectal carcinoma cell growth via disrupting cellular bioenergetics and mitochondrial dynamics.
    Li L, Chen Q, Yu Y, Chen H, Lu M, Huang Y, Li P, Chang H.
    J Cell Physiol; 2020 Jan 30; 235(1):254-266. PubMed ID: 31237697
    [Abstract] [Full Text] [Related]

  • 4. A novel small-molecule MRCK inhibitor blocks cancer cell invasion.
    Unbekandt M, Croft DR, Crighton D, Mezna M, McArthur D, McConnell P, Schüttelkopf AW, Belshaw S, Pannifer A, Sime M, Bower J, Drysdale M, Olson MF.
    Cell Commun Signal; 2014 Oct 05; 12():54. PubMed ID: 25288205
    [Abstract] [Full Text] [Related]

  • 5. Discovery of novel pyrazolo[1,5-a]pyrimidine derivatives as selective ROCK2 inhibitors with anti-breast cancer migration and invasion activities.
    Cao Z, Wei X, Xing S, Zhang J, Wang S, Yue L, Zhang J, Jiang N, Zhai X.
    Bioorg Chem; 2024 Oct 05; 151():107675. PubMed ID: 39126868
    [Abstract] [Full Text] [Related]

  • 6. Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth.
    Rath N, Munro J, Cutiongco MF, Jagiełło A, Gadegaard N, McGarry L, Unbekandt M, Michalopoulou E, Kamphorst JJ, Sumpton D, Mackay G, Vennin C, Pajic M, Timpson P, Olson MF.
    Cancer Res; 2018 Jun 15; 78(12):3321-3336. PubMed ID: 29669760
    [Abstract] [Full Text] [Related]

  • 7. RKI-1447, a Rho kinase inhibitor, causes ocular hypotension, actin stress fiber disruption, and increased phagocytosis.
    Dang Y, Wang C, Shah P, Waxman S, Loewen RT, Loewen NA.
    Graefes Arch Clin Exp Ophthalmol; 2019 Jan 15; 257(1):101-109. PubMed ID: 30456419
    [Abstract] [Full Text] [Related]

  • 8. Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening.
    Chong CM, Kou MT, Pan P, Zhou H, Ai N, Li C, Zhong HJ, Leung CH, Hou T, Lee SM.
    Mol Biosyst; 2016 Aug 16; 12(9):2713-21. PubMed ID: 27354305
    [Abstract] [Full Text] [Related]

  • 9. 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration.
    Tsai CC, Liu HF, Hsu KC, Yang JM, Chen C, Liu KK, Hsu TS, Chao JI.
    Biochem Pharmacol; 2011 Apr 01; 81(7):856-65. PubMed ID: 21276421
    [Abstract] [Full Text] [Related]

  • 10. Discovery of Rho-kinase inhibitors by docking-based virtual screening.
    Shen M, Yu H, Li Y, Li P, Pan P, Zhou S, Zhang L, Li S, Lee SM, Hou T.
    Mol Biosyst; 2013 Jun 01; 9(6):1511-21. PubMed ID: 23549429
    [Abstract] [Full Text] [Related]

  • 11. Curcumin inhibits LPA-induced invasion by attenuating RhoA/ROCK/MMPs pathway in MCF7 breast cancer cells.
    Sun K, Duan X, Cai H, Liu X, Yang Y, Li M, Zhang X, Wang J.
    Clin Exp Med; 2016 Feb 01; 16(1):37-47. PubMed ID: 25596714
    [Abstract] [Full Text] [Related]

  • 12. Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors.
    Dayal N, Mikek CG, Hernandez D, Naclerio GA, Yin Chu EF, Carter-Cooper BA, Lapidus RG, Sintim HO.
    Eur J Med Chem; 2019 Oct 15; 180():449-456. PubMed ID: 31330446
    [Abstract] [Full Text] [Related]

  • 13. Design and development of novel fasudil derivatives as potent antibreast cancer agent that improves intestinal flora and intestinal barrier function in rats.
    Liang J, Tang M, Wang L, Huang R, Fu A, Zhou J.
    Chem Biol Drug Des; 2021 Dec 15; 98(6):1065-1078. PubMed ID: 34587363
    [Abstract] [Full Text] [Related]

  • 14. Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context.
    Matsubara M, Bissell MJ.
    Oncotarget; 2016 May 31; 7(22):31602-22. PubMed ID: 27203208
    [Abstract] [Full Text] [Related]

  • 15. Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway.
    Kidera Y, Tsubaki M, Yamazoe Y, Shoji K, Nakamura H, Ogaki M, Satou T, Itoh T, Isozaki M, Kaneko J, Tanimori Y, Yanae M, Nishida S.
    J Exp Clin Cancer Res; 2010 Sep 16; 29(1):127. PubMed ID: 20843370
    [Abstract] [Full Text] [Related]

  • 16. The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid.
    Wang J, Jiang W.
    Med Sci Monit; 2020 Feb 06; 26():e919220. PubMed ID: 32026851
    [Abstract] [Full Text] [Related]

  • 17. ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration.
    Ortíz-López L, Morales-Mulia S, Ramírez-Rodríguez G, Benítez-King G.
    J Pineal Res; 2009 Jan 06; 46(1):15-21. PubMed ID: 18482340
    [Abstract] [Full Text] [Related]

  • 18. ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion.
    Vigil D, Kim TY, Plachco A, Garton AJ, Castaldo L, Pachter JA, Dong H, Chen X, Tokar B, Campbell SL, Der CJ.
    Cancer Res; 2012 Oct 15; 72(20):5338-47. PubMed ID: 22942252
    [Abstract] [Full Text] [Related]

  • 19. Plumbagin reduces osteopontin-induced invasion through inhibiting the Rho-associated kinase signaling pathway in A549 cells and suppresses osteopontin-induced lung metastasis in BalB/c mice.
    Kang CG, Im E, Lee HJ, Lee EO.
    Bioorg Med Chem Lett; 2017 May 01; 27(9):1914-1918. PubMed ID: 28359791
    [Abstract] [Full Text] [Related]

  • 20. Fragment-based and structure-guided discovery and optimization of Rho kinase inhibitors.
    Li R, Martin MP, Liu Y, Wang B, Patel RA, Zhu JY, Sun N, Pireddu R, Lawrence NJ, Li J, Haura EB, Sung SS, Guida WC, Schonbrunn E, Sebti SM.
    J Med Chem; 2012 Mar 08; 55(5):2474-8. PubMed ID: 22272748
    [Abstract] [Full Text] [Related]

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