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246 related items for PubMed ID: 22869680

  • 1. Mutant human APP exacerbates pathology in a mouse model of NPC and its reversal by a β-cyclodextrin.
    Maulik M, Ghoshal B, Kim J, Wang Y, Yang J, Westaway D, Kar S.
    Hum Mol Genet; 2012 Nov 15; 21(22):4857-75. PubMed ID: 22869680
    [Abstract] [Full Text] [Related]

  • 2. Alterations in gene expression in mutant amyloid precursor protein transgenic mice lacking Niemann-Pick type C1 protein.
    Maulik M, Thinakaran G, Kar S.
    PLoS One; 2013 Nov 15; 8(1):e54605. PubMed ID: 23382922
    [Abstract] [Full Text] [Related]

  • 3. Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis.
    Nunes A, Pressey SN, Cooper JD, Soriano S.
    Neurobiol Dis; 2011 Jun 15; 42(3):349-59. PubMed ID: 21303697
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  • 4. APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.
    Maulik M, Peake K, Chung J, Wang Y, Vance JE, Kar S.
    Hum Mol Genet; 2015 Dec 15; 24(24):7132-50. PubMed ID: 26433932
    [Abstract] [Full Text] [Related]

  • 5. Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice.
    Umeda T, Tomiyama T, Kitajima E, Idomoto T, Nomura S, Lambert MP, Klein WL, Mori H.
    Life Sci; 2012 Dec 10; 91(23-24):1169-76. PubMed ID: 22273754
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  • 8. Spatial and temporal distribution of intracellular free cholesterol in brains of a Niemann-Pick type C mouse model showing hyperphosphorylated tau protein. Implications for Alzheimer's disease.
    Treiber-Held S, Distl R, Meske V, Albert F, Ohm TG.
    J Pathol; 2003 May 10; 200(1):95-103. PubMed ID: 12692847
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  • 9. A Potential Role for the Amyloid Precursor Protein in the Regulation of Interferon Signaling, Cholesterol Homeostasis, and Tau Phosphorylation in Niemann-Pick Disease Type C.
    Sanchez KL, Shin SD, Rajagopal NP, White JB, Currais A, Soriano-Castell D, Maher P, Soriano S.
    Genes (Basel); 2024 Aug 13; 15(8):. PubMed ID: 39202426
    [Abstract] [Full Text] [Related]

  • 10. Alpha1-antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons.
    Padmanabhan J, Levy M, Dickson DW, Potter H.
    Brain; 2006 Nov 13; 129(Pt 11):3020-34. PubMed ID: 16987932
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  • 11. Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice.
    Leroy K, Ando K, Laporte V, Dedecker R, Suain V, Authelet M, Héraud C, Pierrot N, Yilmaz Z, Octave JN, Brion JP.
    Am J Pathol; 2012 Dec 13; 181(6):1928-40. PubMed ID: 23026200
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  • 12. Amyloid-β metabolism in Niemann-Pick C disease models and patients.
    Mattsson N, Olsson M, Gustavsson MK, Kosicek M, Malnar M, Månsson JE, Blomqvist M, Gobom J, Andreasson U, Brinkmalm G, Vite C, Hecimovic S, Hastings C, Blennow K, Zetterberg H, Portelius E.
    Metab Brain Dis; 2012 Dec 13; 27(4):573-85. PubMed ID: 22935999
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  • 13. Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease.
    Saul A, Sprenger F, Bayer TA, Wirths O.
    Neurobiol Aging; 2013 Nov 13; 34(11):2564-73. PubMed ID: 23747045
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  • 14. Altered apolipoprotein E glycosylation is associated with Abeta(42) accumulation in an animal model of Niemann-Pick Type C disease.
    Chua CC, Lim ML, Wong BS.
    J Neurochem; 2010 Mar 13; 112(6):1619-26. PubMed ID: 20070866
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  • 15. Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice.
    Ribé EM, Pérez M, Puig B, Gich I, Lim F, Cuadrado M, Sesma T, Catena S, Sánchez B, Nieto M, Gómez-Ramos P, Morán MA, Cabodevilla F, Samaranch L, Ortiz L, Pérez A, Ferrer I, Avila J, Gómez-Isla T.
    Neurobiol Dis; 2005 Dec 13; 20(3):814-22. PubMed ID: 16125396
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  • 16. Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.
    Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K.
    Eur J Neurosci; 2004 May 13; 19(10):2826-38. PubMed ID: 15147316
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  • 17. Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C.
    Shin SD, Shin A, Mayagoitia K, Siebold L, Rubini M, Wilson CG, Bellinger DL, Soriano S.
    J Neuroinflammation; 2019 Dec 17; 16(1):269. PubMed ID: 31847862
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  • 18. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
    Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E.
    Science; 2001 Aug 24; 293(5534):1487-91. PubMed ID: 11520987
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  • 19. GGA1 overexpression attenuates amyloidogenic processing of the amyloid precursor protein in Niemann-Pick type C cells.
    Kosicek M, Wunderlich P, Walter J, Hecimovic S.
    Biochem Biophys Res Commun; 2014 Jul 18; 450(1):160-5. PubMed ID: 24866237
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