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131 related items for PubMed ID: 22889611

  • 1. The trypanothione system and its implications in the therapy of trypanosomatid diseases.
    Flohé L.
    Int J Med Microbiol; 2012 Oct; 302(4-5):216-20. PubMed ID: 22889611
    [Abstract] [Full Text] [Related]

  • 2. Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity.
    González-Chávez Z, Vázquez C, Mejia-Tlachi M, Márquez-Dueñas C, Manning-Cela R, Encalada R, Rodríguez-Enríquez S, Michels PAM, Moreno-Sánchez R, Saavedra E.
    Redox Biol; 2019 Sep; 26():101231. PubMed ID: 31203195
    [Abstract] [Full Text] [Related]

  • 3. Targeting trypanothione metabolism in trypanosomatid human parasites.
    Olin-Sandoval V, Moreno-Sánchez R, Saavedra E.
    Curr Drug Targets; 2010 Dec; 11(12):1614-30. PubMed ID: 20735352
    [Abstract] [Full Text] [Related]

  • 4. The trypanothione system and the opportunities it offers to create drugs for the neglected kinetoplast diseases.
    Flohé L.
    Biotechnol Adv; 2012 Dec; 30(1):294-301. PubMed ID: 21620942
    [Abstract] [Full Text] [Related]

  • 5. Targeting Trypanothione Metabolism in Trypanosomatids.
    González-Montero MC, Andrés-Rodríguez J, García-Fernández N, Pérez-Pertejo Y, Reguera RM, Balaña-Fouce R, García-Estrada C.
    Molecules; 2024 May 09; 29(10):. PubMed ID: 38792079
    [Abstract] [Full Text] [Related]

  • 6. Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development.
    Schmidt A, Krauth-Siegel RL.
    Curr Top Med Chem; 2002 Nov 09; 2(11):1239-59. PubMed ID: 12171583
    [Abstract] [Full Text] [Related]

  • 7. The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
    Krauth-Siegel RL, Meiering SK, Schmidt H.
    Biol Chem; 2003 Apr 09; 384(4):539-49. PubMed ID: 12751784
    [Abstract] [Full Text] [Related]

  • 8. Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.
    Colotti G, Baiocco P, Fiorillo A, Boffi A, Poser E, Chiaro FD, Ilari A.
    Future Med Chem; 2013 Oct 09; 5(15):1861-75. PubMed ID: 24144416
    [Abstract] [Full Text] [Related]

  • 9. The Achilles' heel of trypanosomatids: trypanothione-mediated hydroperoxide metabolism.
    Flohé L.
    Biofactors; 1998 Oct 09; 8(1-2):87-91. PubMed ID: 9699014
    [No Abstract] [Full Text] [Related]

  • 10. Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism.
    Saccoliti F, Di Santo R, Costi R.
    ChemMedChem; 2020 Dec 15; 15(24):2420-2435. PubMed ID: 32805075
    [Abstract] [Full Text] [Related]

  • 11. Thiol-based redox metabolism of protozoan parasites.
    Müller S, Liebau E, Walter RD, Krauth-Siegel RL.
    Trends Parasitol; 2003 Jul 15; 19(7):320-8. PubMed ID: 12855383
    [Abstract] [Full Text] [Related]

  • 12. Glutathione and trypanothione in parasitic hydroperoxide metabolism.
    Flohé L, Hecht HJ, Steinert P.
    Free Radic Biol Med; 1999 Nov 15; 27(9-10):966-84. PubMed ID: 10569629
    [Abstract] [Full Text] [Related]

  • 13. Preparative enzymatic synthesis of trypanothione and trypanothione analogues.
    Comini MA, Dirdjaja N, Kaschel M, Krauth-Siegel RL.
    Int J Parasitol; 2009 Aug 15; 39(10):1059-62. PubMed ID: 19477177
    [Abstract] [Full Text] [Related]

  • 14. Peroxidases of trypanosomatids.
    Castro H, Tomás AM.
    Antioxid Redox Signal; 2008 Sep 15; 10(9):1593-606. PubMed ID: 18498224
    [Abstract] [Full Text] [Related]

  • 15. Drug target validation of the trypanothione pathway enzymes through metabolic modelling.
    Olin-Sandoval V, González-Chávez Z, Berzunza-Cruz M, Martínez I, Jasso-Chávez R, Becker I, Espinoza B, Moreno-Sánchez R, Saavedra E.
    FEBS J; 2012 May 15; 279(10):1811-33. PubMed ID: 22394478
    [Abstract] [Full Text] [Related]

  • 16. Trypanothione biosynthesis in Leishmania major.
    Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
    Mol Biochem Parasitol; 2005 Jan 15; 139(1):107-16. PubMed ID: 15610825
    [Abstract] [Full Text] [Related]

  • 17. Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei.
    Zimmermann S, Oufir M, Leroux A, Krauth-Siegel RL, Becker K, Kaiser M, Brun R, Hamburger M, Adams M.
    Bioorg Med Chem; 2013 Nov 15; 21(22):7202-9. PubMed ID: 24080104
    [Abstract] [Full Text] [Related]

  • 18. Thiol redox biology of trypanosomatids and potential targets for chemotherapy.
    Leroux AE, Krauth-Siegel RL.
    Mol Biochem Parasitol; 2016 Nov 15; 206(1-2):67-74. PubMed ID: 26592324
    [Abstract] [Full Text] [Related]

  • 19. Phenotypic analysis of trypanothione synthetase knockdown in the African trypanosome.
    Ariyanayagam MR, Oza SL, Guther ML, Fairlamb AH.
    Biochem J; 2005 Oct 15; 391(Pt 2):425-32. PubMed ID: 16008527
    [Abstract] [Full Text] [Related]

  • 20. Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification.
    Irigoín F, Cibils L, Comini MA, Wilkinson SR, Flohé L, Radi R.
    Free Radic Biol Med; 2008 Sep 15; 45(6):733-42. PubMed ID: 18588970
    [Abstract] [Full Text] [Related]

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