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Journal Abstract Search

209 related items for PubMed ID: 22907907

  • 1. Beyond heparinization: design of highly potent thrombin inhibitors suitable for surface coupling.
    Steinmetzer T, Baum B, Biela A, Klebe G, Nowak G, Bucha E.
    ChemMedChem; 2012 Nov; 7(11):1965-73. PubMed ID: 22907907
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  • 4. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
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  • 9. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.
    Baum B, Muley L, Heine A, Smolinski M, Hangauer D, Klebe G.
    J Mol Biol; 2009 Aug 21; 391(3):552-64. PubMed ID: 19520086
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  • 10. Structure-based design of residue 1 analogs of the direct thrombin inhibitor pentapeptide FM 19.
    Girnys EA, Sobczyk-Kojiro K, Mosberg HI.
    Chem Biol Drug Des; 2010 Jan 21; 75(1):35-9. PubMed ID: 19954432
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  • 12. Compounds binding to the S2-S3 pockets of thrombin.
    Nilsson M, Hämäläinen M, Ivarsson M, Gottfries J, Xue Y, Hansson S, Isaksson R, Fex T.
    J Med Chem; 2009 May 14; 52(9):2708-15. PubMed ID: 19371038
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  • 14. Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles.
    Isaacs RC, Solinsky MG, Cutrona KJ, Newton CL, Naylor-Olsen AM, McMasters DR, Krueger JA, Lewis SD, Lucas BJ, Kuo LC, Yan Y, Lynch JJ, Lyle EA.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):2062-6. PubMed ID: 18291642
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  • 16. Nonpolar interactions of thrombin S' subsites with its bivalent inhibitor: methyl scan of the inhibitor linker.
    Slon-Usakiewicz JJ, Purisima E, Tsuda Y, Sulea T, Pedyczak A, Féthière J, Cygler M, Konishi Y.
    Biochemistry; 1997 Nov 04; 36(44):13494-502. PubMed ID: 9354617
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  • 17. Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis.
    Lu T, Markotan T, Coppo F, Tomczuk B, Crysler C, Eisennagel S, Spurlino J, Gremminger L, Soll RM, Giardino EC, Bone R.
    Bioorg Med Chem Lett; 2004 Jul 16; 14(14):3727-31. PubMed ID: 15203151
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  • 18. Highly potent and selective substrate analogue factor Xa inhibitors containing D-homophenylalanine analogues as P3 residue: part 2.
    Stürzebecher A, Dönnecke D, Schweinitz A, Schuster O, Steinmetzer P, Stürzebecher U, Kotthaus J, Clement B, Stürzebecher J, Steinmetzer T.
    ChemMedChem; 2007 Jul 16; 2(7):1043-53. PubMed ID: 17541992
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  • 19. Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa.
    Lazarova TI, Jin L, Rynkiewicz M, Gorga JC, Bibbins F, Meyers HV, Babine R, Strickler J.
    Bioorg Med Chem Lett; 2006 Oct 01; 16(19):5022-7. PubMed ID: 16876411
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