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Journal Abstract Search

209 related items for PubMed ID: 22907907

  • 21.
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  • 22.
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  • 23. The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage.
    Friedrich R, Steinmetzer T, Huber R, Stürzebecher J, Bode W.
    J Mol Biol; 2002 Mar 01; 316(4):869-74. PubMed ID: 11884127
    [Abstract] [Full Text] [Related]

  • 24. Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.
    De Simone G, Menchise V, Omaggio S, Pedone C, Scozzafava A, Supuran CT.
    Biochemistry; 2003 Aug 05; 42(30):9013-21. PubMed ID: 12885234
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  • 26. Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 5. Potency, efficacy, and pharmacokinetic properties of modified C-3 side chain derivatives.
    Sall DJ, Bailey DL, Bastian JA, Buben JA, Chirgadze NY, Clemens-Smith AC, Denney ML, Fisher MJ, Giera DD, Gifford-Moore DS, Harper RW, Johnson LM, Klimkowski VJ, Kohn TJ, Lin HS, McCowan JR, Palkowitz AD, Richett ME, Smith GF, Snyder DW, Takeuchi K, Toth JE, Zhang M.
    J Med Chem; 2000 Feb 24; 43(4):649-63. PubMed ID: 10691691
    [Abstract] [Full Text] [Related]

  • 27. Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
    Nardini M, Pesce A, Rizzi M, Casale E, Ferraccioli R, Balliano G, Milla P, Ascenzi P, Bolognesi M.
    J Mol Biol; 1996 May 24; 258(5):851-9. PubMed ID: 8637015
    [Abstract] [Full Text] [Related]

  • 28.
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  • 29. Dibasic benzo[b]thiophene derivatives as a novel class of active site-directed thrombin inhibitors. 1. Determination of the serine protease selectivity, structure-activity relationships, and binding orientation.
    Sall DJ, Bastian JA, Briggs SL, Buben JA, Chirgadze NY, Clawson DK, Denney ML, Giera DD, Gifford-Moore DS, Harper RW, Hauser KL, Klimkowski VJ, Kohn TJ, Lin HS, McCowan JR, Palkowitz AD, Smith GF, Takeuchi K, Thrasher KJ, Tinsley JM, Utterback BG, Yan SC, Zhang M.
    J Med Chem; 1997 Oct 24; 40(22):3489-93. PubMed ID: 9357512
    [No Abstract] [Full Text] [Related]

  • 30. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
    Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK.
    Biochemistry; 1998 Sep 01; 37(35):12094-103. PubMed ID: 9724521
    [Abstract] [Full Text] [Related]

  • 31. Design, synthesis and biological evaluation of selective boron-containing thrombin inhibitors.
    Wienand A, Ehrhardt C, Metternich R, Tapparelli C.
    Bioorg Med Chem; 1999 Jul 01; 7(7):1295-307. PubMed ID: 10465405
    [Abstract] [Full Text] [Related]

  • 32. Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure.
    Hanessian S, Therrien E, van Otterlo WA, Bayrakdarian M, Nilsson I, Fjellström O, Xue Y.
    Bioorg Med Chem Lett; 2006 Feb 15; 16(4):1032-6. PubMed ID: 16290930
    [Abstract] [Full Text] [Related]

  • 33. Selection of S18326 as a new potent and selective boronic acid direct thrombin inhibitor.
    Rupin A, Mennecier P, Lila C, de Nanteuil G, Verbeuren TJ.
    Thromb Haemost; 1997 Oct 15; 78(4):1221-7. PubMed ID: 9364988
    [Abstract] [Full Text] [Related]

  • 34. Synthesis of potential thrombin inhibitors. Incorporation of tartaric acid templates as P2 proline mimetics.
    Dahlgren A, Brånalt J, Kvarnström I, Nilsson I, Musil D, Samuelsson B.
    Bioorg Med Chem; 2002 May 15; 10(5):1567-80. PubMed ID: 11886818
    [Abstract] [Full Text] [Related]

  • 35. Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases.
    Katz BA, Luong C.
    J Mol Biol; 1999 Sep 24; 292(3):669-84. PubMed ID: 10497030
    [Abstract] [Full Text] [Related]

  • 36. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
    Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W.
    J Mol Biol; 2001 Apr 13; 307(5):1451-86. PubMed ID: 11292354
    [Abstract] [Full Text] [Related]

  • 37. Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
    Phillips GB, Buckman BO, Davey DD, Eagen KA, Guilford WJ, Hinchman J, Ho E, Koovakkat S, Liang A, Light DR, Mohan R, Ng HP, Post JM, Shaw KJ, Smith D, Subramanyam B, Sullivan ME, Trinh L, Vergona R, Walters J, White K, Whitlow M, Wu S, Xu W, Morrissey MM.
    J Med Chem; 1998 Sep 10; 41(19):3557-62. PubMed ID: 9733480
    [No Abstract] [Full Text] [Related]

  • 38. Iterative optimization of high-affinity protease inhibitors using phage display. 2. Plasma kallikrein and thrombin.
    Markland W, Ley AC, Ladner RC.
    Biochemistry; 1996 Jun 18; 35(24):8058-67. PubMed ID: 8672510
    [Abstract] [Full Text] [Related]

  • 39. Secondary structure peptide mimetics: design, synthesis, and evaluation of beta-strand mimetic thrombin inhibitors.
    Boatman PD, Ogbu CO, Eguchi M, Kim HO, Nakanishi H, Cao B, Shea JP, Kahn M.
    J Med Chem; 1999 Apr 22; 42(8):1367-75. PubMed ID: 10212122
    [Abstract] [Full Text] [Related]

  • 40. Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors.
    Wagner J, Kallen J, Ehrhardt C, Evenou JP, Wagner D.
    J Med Chem; 1998 Sep 10; 41(19):3664-74. PubMed ID: 9733491
    [Abstract] [Full Text] [Related]

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