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Journal Abstract Search

209 related items for PubMed ID: 22907907

  • 41. Design, synthesis, and biological activity of potent and selective inhibitors of blood coagulation factor Xa.
    Willardsen JA, Dudley DA, Cody WL, Chi L, McClanahan TB, Mertz TE, Potoczak RE, Narasimhan LS, Holland DR, Rapundalo ST, Edmunds JJ.
    J Med Chem; 2004 Jul 29; 47(16):4089-99. PubMed ID: 15267248
    [Abstract] [Full Text] [Related]

  • 42. Synthesis, characterization and in vitro activity of thrombin-binding DNA aptamers with triazole internucleotide linkages.
    Varizhuk AM, Tsvetkov VB, Tatarinova ON, Kaluzhny DN, Florentiev VL, Timofeev EN, Shchyolkina AK, Borisova OF, Smirnov IP, Grokhovsky SL, Aseychev AV, Pozmogova GE.
    Eur J Med Chem; 2013 Sep 29; 67():90-7. PubMed ID: 23850569
    [Abstract] [Full Text] [Related]

  • 43. Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template.
    Jhoti H, Cleasby A, Reid S, Thomas PJ, Weir M, Wonacott A.
    Biochemistry; 1999 Jun 22; 38(25):7969-77. PubMed ID: 10387040
    [Abstract] [Full Text] [Related]

  • 44. Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors.
    Platte S, Korff M, Imberg L, Balicioglu I, Erbacher C, Will JM, Daniliuc CG, Karst U, Kalinin DV.
    ChemMedChem; 2021 Dec 14; 16(24):3672-3690. PubMed ID: 34278727
    [Abstract] [Full Text] [Related]

  • 45. New substrate analogue inhibitors of factor Xa containing 4-amidinobenzylamide as P1 residue: part 1.
    Schweinitz A, Stürzebecher A, Stürzebecher U, Schuster O, Stürzebecher J, Steinmetzer T.
    Med Chem; 2006 Jul 14; 2(4):349-61. PubMed ID: 16848746
    [Abstract] [Full Text] [Related]

  • 46. Rational design and synthesis of novel, potent bis-phenylamidine carboxylate factor Xa inhibitors.
    Maduskuie TP, McNamara KJ, Ru Y, Knabb RM, Stouten PF.
    J Med Chem; 1998 Jan 01; 41(1):53-62. PubMed ID: 9438022
    [Abstract] [Full Text] [Related]

  • 47. Novel non-covalent thrombin inhibitors incorporating P(1) 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics.
    Marinko P, Krbavcic A, Mlinsek G, Solmajer T, Bakija AT, Stegnar M, Stojan J, Kikelj D.
    Eur J Med Chem; 2004 Mar 01; 39(3):257-65. PubMed ID: 15051174
    [Abstract] [Full Text] [Related]

  • 48. Generation of ligand conformations in continuum solvent consistent with protein active site topology: application to thrombin.
    Greenidge PA, Mérette SA, Beck R, Dodson G, Goodwin CA, Scully MF, Spencer J, Weiser J, Deadman JJ.
    J Med Chem; 2003 Apr 10; 46(8):1293-305. PubMed ID: 12672230
    [Abstract] [Full Text] [Related]

  • 49. Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.
    Weir MP, Bethell SS, Cleasby A, Campbell CJ, Dennis RJ, Dix CJ, Finch H, Jhoti H, Mooney CJ, Patel S, Tang CM, Ward M, Wonacott AJ, Wharton CW.
    Biochemistry; 1998 May 12; 37(19):6645-57. PubMed ID: 9578548
    [Abstract] [Full Text] [Related]

  • 50. Development of Trypsin-Like Serine Protease Inhibitors as Therapeutic Agents: Opportunities, Challenges, and their Unique Structure-Based Rationales.
    Liang G, Bowen JP.
    Curr Top Med Chem; 2016 May 12; 16(13):1506-29. PubMed ID: 26369819
    [Abstract] [Full Text] [Related]

  • 51. Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs.
    Hanessian S, Simard D, Bayrakdarian M, Therrien E, Nilsson I, Fjellström O.
    Bioorg Med Chem Lett; 2008 Mar 15; 18(6):1972-6. PubMed ID: 18289852
    [Abstract] [Full Text] [Related]

  • 52. Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors.
    Zbinden KG, Obst-Sander U, Hilpert K, Kühne H, Banner DW, Böhm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lavé T.
    Bioorg Med Chem Lett; 2005 Dec 01; 15(23):5344-52. PubMed ID: 16213138
    [Abstract] [Full Text] [Related]

  • 53. Tetrahydro-isoquinoline-based factor Xa inhibitors.
    Kucznierz R, Grams F, Leinert H, Marzenell K, Engh RA, von der Saal W.
    J Med Chem; 1998 Dec 03; 41(25):4983-94. PubMed ID: 9836616
    [Abstract] [Full Text] [Related]

  • 54. In vitro and in vivo activities of oligodeoxynucleotide-based thrombin inhibitors containing neutral formacetal linkages.
    He GX, Williams JP, Postich MJ, Swaminathan S, Shea RG, Terhorst T, Law VS, Mao CT, Sueoka C, Coutré S, Bischofberger N.
    J Med Chem; 1998 Oct 22; 41(22):4224-31. PubMed ID: 9784097
    [Abstract] [Full Text] [Related]

  • 55. Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV.
    Karle M, Knecht W, Xue Y.
    Bioorg Med Chem Lett; 2012 Jul 15; 22(14):4839-43. PubMed ID: 22726924
    [Abstract] [Full Text] [Related]

  • 56. Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores.
    Kotian PL, Krishnan R, Rowland S, El-Kattan Y, Saini SK, Upshaw R, Bantia S, Arnold S, Babu YS, Chand P.
    Bioorg Med Chem; 2009 Jun 01; 17(11):3934-58. PubMed ID: 19409795
    [Abstract] [Full Text] [Related]

  • 57. A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions.
    Olsen JA, Banner DW, Seiler P, Obst Sander U, D'Arcy A, Stihle M, Müller K, Diederich F.
    Angew Chem Int Ed Engl; 2003 Jun 06; 42(22):2507-11. PubMed ID: 12800172
    [No Abstract] [Full Text] [Related]

  • 58. Inhibitors of serine proteinases from blood coagulation cascade - view on current developments.
    Danalev D.
    Mini Rev Med Chem; 2012 Jul 06; 12(8):721-30. PubMed ID: 22512557
    [Abstract] [Full Text] [Related]

  • 59. Prediction of enzyme binding: human thrombin inhibition study by quantum chemical and artificial intelligence methods based on X-ray structures.
    Mlinsek G, Novic M, Hodoscek M, Solmajer T.
    J Chem Inf Comput Sci; 2001 Jul 06; 41(5):1286-94. PubMed ID: 11604028
    [Abstract] [Full Text] [Related]

  • 60. How a β-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties.
    Belviso BD, Caliandro R, de Candia M, Zaetta G, Lopopolo G, Incampo F, Colucci M, Altomare CD.
    J Med Chem; 2014 Oct 23; 57(20):8563-75. PubMed ID: 25268757
    [Abstract] [Full Text] [Related]

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