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Journal Abstract Search

192 related items for PubMed ID: 22908166

  • 1. Substitutions at position 105 in SHV family β-lactamases decrease catalytic efficiency and cause inhibitor resistance.
    Li M, Conklin BC, Taracila MA, Hutton RA, Skalweit MJ.
    Antimicrob Agents Chemother; 2012 Nov; 56(11):5678-86. PubMed ID: 22908166
    [Abstract] [Full Text] [Related]

  • 2. Overcoming resistance to beta-lactamase inhibitors: comparing sulbactam to novel inhibitors against clavulanate resistant SHV enzymes with substitutions at Ambler position 244.
    Thomson JM, Distler AM, Bonomo RA.
    Biochemistry; 2007 Oct 09; 46(40):11361-8. PubMed ID: 17848099
    [Abstract] [Full Text] [Related]

  • 3. Variants of β-lactamase KPC-2 that are resistant to inhibition by avibactam.
    Papp-Wallace KM, Winkler ML, Taracila MA, Bonomo RA.
    Antimicrob Agents Chemother; 2015 Jul 09; 59(7):3710-7. PubMed ID: 25666153
    [Abstract] [Full Text] [Related]

  • 4. Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.
    Papp-Wallace KM, Taracila M, Hornick JM, Hujer AM, Hujer KM, Distler AM, Endimiani A, Bonomo RA.
    Antimicrob Agents Chemother; 2010 Jul 09; 54(7):2867-77. PubMed ID: 20421396
    [Abstract] [Full Text] [Related]

  • 5. Aspartic acid for asparagine substitution at position 276 reduces susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 beta-lactamases.
    Giakkoupi P, Tzelepi E, Legakis NJ, Tzouvelekis LS.
    J Antimicrob Chemother; 1999 Jan 09; 43(1):23-9. PubMed ID: 10381097
    [Abstract] [Full Text] [Related]

  • 6. Elucidating the role of Trp105 in the KPC-2 β-lactamase.
    Papp-Wallace KM, Taracila M, Wallace CJ, Hujer KM, Bethel CR, Hornick JM, Bonomo RA.
    Protein Sci; 2010 Sep 09; 19(9):1714-27. PubMed ID: 20662006
    [Abstract] [Full Text] [Related]

  • 7. Understanding the molecular determinants of substrate and inhibitor specificities in the Carbapenemase KPC-2: exploring the roles of Arg220 and Glu276.
    Papp-Wallace KM, Taracila MA, Smith KM, Xu Y, Bonomo RA.
    Antimicrob Agents Chemother; 2012 Aug 09; 56(8):4428-38. PubMed ID: 22687511
    [Abstract] [Full Text] [Related]

  • 8. The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.
    Drawz SM, Bethel CR, Hujer KM, Hurless KN, Distler AM, Caselli E, Prati F, Bonomo RA.
    Biochemistry; 2009 Jun 02; 48(21):4557-66. PubMed ID: 19351161
    [Abstract] [Full Text] [Related]

  • 9. Characterization of the inhibitor-resistant SHV β-lactamase SHV-107 in a clinical Klebsiella pneumoniae strain coproducing GES-7 enzyme.
    Manageiro V, Ferreira E, Cougnoux A, Albuquerque L, Caniça M, Bonnet R.
    Antimicrob Agents Chemother; 2012 Feb 02; 56(2):1042-6. PubMed ID: 22083476
    [Abstract] [Full Text] [Related]

  • 10. Inhibitor resistance in the KPC-2 beta-lactamase, a preeminent property of this class A beta-lactamase.
    Papp-Wallace KM, Bethel CR, Distler AM, Kasuboski C, Taracila M, Bonomo RA.
    Antimicrob Agents Chemother; 2010 Feb 02; 54(2):890-7. PubMed ID: 20008772
    [Abstract] [Full Text] [Related]

  • 11. Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition.
    Sulton D, Pagan-Rodriguez D, Zhou X, Liu Y, Hujer AM, Bethel CR, Helfand MS, Thomson JM, Anderson VE, Buynak JD, Ng LM, Bonomo RA.
    J Biol Chem; 2005 Oct 21; 280(42):35528-36. PubMed ID: 15987690
    [Abstract] [Full Text] [Related]

  • 12. Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene.
    Vakulenko SB, Geryk B, Kotra LP, Mobashery S, Lerner SA.
    Antimicrob Agents Chemother; 1998 Jul 21; 42(7):1542-8. PubMed ID: 9660980
    [Abstract] [Full Text] [Related]

  • 13. Substitution of Arg-244 by Cys or Ser in SHV-1 and SHV-5 beta-lactamases confers resistance to mechanism-based inhibitors and reduces catalytic efficiency of the enzymes.
    Giakkoupi P, Tzelepi E, Legakis NJ, Tzouvelekis LS.
    FEMS Microbiol Lett; 1998 Mar 01; 160(1):49-54. PubMed ID: 9495011
    [Abstract] [Full Text] [Related]

  • 14. Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.
    Helfand MS, Bethel CR, Hujer AM, Hujer KM, Anderson VE, Bonomo RA.
    J Biol Chem; 2003 Dec 26; 278(52):52724-9. PubMed ID: 14534312
    [Abstract] [Full Text] [Related]

  • 15. Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis β-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of β-lactam-β-lactamase inhibitor combinations.
    Kurz SG, Wolff KA, Hazra S, Bethel CR, Hujer AM, Smith KM, Xu Y, Tremblay LW, Blanchard JS, Nguyen L, Bonomo RA.
    Antimicrob Agents Chemother; 2013 Dec 26; 57(12):6085-96. PubMed ID: 24060876
    [Abstract] [Full Text] [Related]

  • 16. Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems.
    Bethel CR, Taracila M, Shyr T, Thomson JM, Distler AM, Hujer KM, Hujer AM, Endimiani A, Papp-Wallace K, Bonnet R, Bonomo RA.
    Antimicrob Agents Chemother; 2011 Jul 26; 55(7):3465-75. PubMed ID: 21555770
    [Abstract] [Full Text] [Related]

  • 17. Substitution of Met-69 by Ala or Gly in TEM-1 beta-lactamase confer an increased susceptibility to clavulanic acid and other inhibitors.
    Madec S, Blin C, Krishnamoorthy R, Picard B, Chaibi el B, Fouchereau-Péron M, Labia R.
    FEMS Microbiol Lett; 2002 May 21; 211(1):13-6. PubMed ID: 12052544
    [Abstract] [Full Text] [Related]

  • 18. Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV β-lactamases with single amino acid substitutions in the Ω-loop.
    Winkler ML, Papp-Wallace KM, Bonomo RA.
    J Antimicrob Chemother; 2015 Aug 21; 70(8):2279-86. PubMed ID: 25957381
    [Abstract] [Full Text] [Related]

  • 19. Structure-function studies of arginine at position 276 in CTX-M beta-lactamases.
    Pérez-Llarena FJ, Cartelle M, Mallo S, Beceiro A, Pérez A, Villanueva R, Romero A, Bonnet R, Bou G.
    J Antimicrob Chemother; 2008 Apr 21; 61(4):792-7. PubMed ID: 18281307
    [Abstract] [Full Text] [Related]

  • 20. Properties of mutant SHV-5 beta-lactamases constructed by substitution of isoleucine or valine for methionine at position 69.
    Giakkoupi P, Miriagou V, Gazouli M, Tzelepi E, Legakis NJ, Tzouvelekis LS.
    Antimicrob Agents Chemother; 1998 May 21; 42(5):1281-3. PubMed ID: 9593168
    [Abstract] [Full Text] [Related]

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