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Journal Abstract Search

340 related items for PubMed ID: 22929232

  • 1. Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.
    Jiao X, Kopecky DJ, Liu J, Liu J, Jaen JC, Cardozo MG, Sharma R, Walker N, Wesche H, Li S, Farrelly E, Xiao SH, Wang Z, Kayser F.
    Bioorg Med Chem Lett; 2012 Oct 01; 22(19):6212-7. PubMed ID: 22929232
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines.
    Kaspersen SJ, Sørum C, Willassen V, Fuglseth E, Kjøbli E, Bjørkøy G, Sundby E, Hoff BH.
    Eur J Med Chem; 2011 Dec 01; 46(12):6002-14. PubMed ID: 22018877
    [Abstract] [Full Text] [Related]

  • 3. Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.
    He L, Pei H, Zhang C, Shao M, Li D, Tang M, Wang T, Chen X, Xiang M, Chen L.
    Eur J Med Chem; 2018 Feb 10; 145():96-112. PubMed ID: 29324347
    [Abstract] [Full Text] [Related]

  • 4. Synthesis, biological evaluation and docking studies of new pyrrolo[2,3-d] pyrimidine derivatives as Src family-selective tyrosine kinase inhibitors.
    Dincer S, Cetin KT, Onay-Besikci A, Ölgen S.
    J Enzyme Inhib Med Chem; 2013 Oct 10; 28(5):1080-7. PubMed ID: 22957720
    [Abstract] [Full Text] [Related]

  • 5. Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase.
    Kurup S, McAllister B, Liskova P, Mistry T, Fanizza A, Stanford D, Slawska J, Keller U, Hoellein A.
    J Enzyme Inhib Med Chem; 2018 Dec 10; 33(1):74-84. PubMed ID: 29115879
    [Abstract] [Full Text] [Related]

  • 6. Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors.
    Le Brazidec JY, Pasis A, Tam B, Boykin C, Wang D, Marcotte DJ, Claassen G, Chong JH, Chao J, Fan J, Nguyen K, Silvian L, Ling L, Zhang L, Choi M, Teng M, Pathan N, Zhao S, Li T, Taveras A.
    Bioorg Med Chem Lett; 2012 Jun 15; 22(12):4033-7. PubMed ID: 22607669
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases.
    Loidreau Y, Marchand P, Dubouilh-Benard C, Nourrisson MR, Duflos M, Loaëc N, Meijer L, Besson T.
    Eur J Med Chem; 2013 Jan 15; 59():283-95. PubMed ID: 23237976
    [Abstract] [Full Text] [Related]

  • 8. Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.
    Addie M, Ballard P, Buttar D, Crafter C, Currie G, Davies BR, Debreczeni J, Dry H, Dudley P, Greenwood R, Johnson PD, Kettle JG, Lane C, Lamont G, Leach A, Luke RW, Morris J, Ogilvie D, Page K, Pass M, Pearson S, Ruston L.
    J Med Chem; 2013 Mar 14; 56(5):2059-73. PubMed ID: 23394218
    [Abstract] [Full Text] [Related]

  • 9. Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.
    Chamberlain SD, Redman AM, Wilson JW, Deanda F, Shotwell JB, Gerding R, Lei H, Yang B, Stevens KL, Hassell AM, Shewchuk LM, Leesnitzer MA, Smith JL, Sabbatini P, Atkins C, Groy A, Rowand JL, Kumar R, Mook RA, Moorthy G, Patnaik S.
    Bioorg Med Chem Lett; 2009 Jan 15; 19(2):360-4. PubMed ID: 19071018
    [Abstract] [Full Text] [Related]

  • 10. Identification and synthesis of substituted pyrrolo[2,3-d]pyrimidines as novel firefly luciferase inhibitors.
    Liu Y, Fang J, Cai H, Xiao F, Ding K, Hu Y.
    Bioorg Med Chem; 2012 Sep 15; 20(18):5473-82. PubMed ID: 22898255
    [Abstract] [Full Text] [Related]

  • 11. Discovery of novel Bruton's tyrosine kinase (BTK) inhibitors bearing a pyrrolo[2,3-d]pyrimidine scaffold.
    Zhao X, Huang W, Wang Y, Xin M, Jin Q, Cai J, Tang F, Zhao Y, Xiang H.
    Bioorg Med Chem; 2015 Feb 15; 23(4):891-901. PubMed ID: 25596757
    [Abstract] [Full Text] [Related]

  • 12. Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
    Cheng H, Nair SK, Murray BW, Almaden C, Bailey S, Baxi S, Behenna D, Cho-Schultz S, Dalvie D, Dinh DM, Edwards MP, Feng JL, Ferre RA, Gajiwala KS, Hemkens MD, Jackson-Fisher A, Jalaie M, Johnson TO, Kania RS, Kephart S, Lafontaine J, Lunney B, Liu KK, Liu Z, Matthews J, Nagata A, Niessen S, Ornelas MA, Orr ST, Pairish M, Planken S, Ren S, Richter D, Ryan K, Sach N, Shen H, Smeal T, Solowiej J, Sutton S, Tran K, Tseng E, Vernier W, Walls M, Wang S, Weinrich SL, Xin S, Xu H, Yin MJ, Zientek M, Zhou R, Kath JC.
    J Med Chem; 2016 Mar 10; 59(5):2005-24. PubMed ID: 26756222
    [Abstract] [Full Text] [Related]

  • 13. Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena.
    Kaspersen SJ, Sundby E, Charnock C, Hoff BH.
    Bioorg Chem; 2012 Oct 10; 44():35-41. PubMed ID: 22832269
    [Abstract] [Full Text] [Related]

  • 14. Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents.
    Gangjee A, Namjoshi OA, Yu J, Ihnat MA, Thorpe JE, Warnke LA.
    Bioorg Med Chem; 2008 May 15; 16(10):5514-28. PubMed ID: 18467105
    [Abstract] [Full Text] [Related]

  • 15. (1)H,(13)C and (19)F NMR data of N-substituted 6-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amines in DMSO-d(6).
    Sørum C, Simić N, Sundby E, Hoff BH.
    Magn Reson Chem; 2010 Mar 15; 48(3):244-8. PubMed ID: 20041453
    [Abstract] [Full Text] [Related]

  • 16. Design, synthesis and evaluation of novel 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as potent, selective and reversible Bruton's tyrosine kinase (BTK) inhibitors for the treatment of rheumatoid arthritis.
    Zhang C, Pei H, He J, Zhu J, Li W, Niu T, Xiang M, Chen L.
    Eur J Med Chem; 2019 May 01; 169():121-143. PubMed ID: 30875504
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors.
    Loidreau Y, Deau E, Marchand P, Nourrisson MR, Logé C, Coadou G, Loaëc N, Meijer L, Besson T.
    Eur J Med Chem; 2015 Mar 06; 92():124-34. PubMed ID: 25549552
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2.
    Golub AG, Bdzhola VG, Briukhovetska NV, Balanda AO, Kukharenko OP, Kotey IM, Ostrynska OV, Yarmoluk SM.
    Eur J Med Chem; 2011 Mar 06; 46(3):870-6. PubMed ID: 21276643
    [Abstract] [Full Text] [Related]

  • 19. Synthesis, biological evaluation and docking studies of 4-amino substituted 1H-pyrazolo[3,4-d]pyrimidines.
    Schenone S, Brullo C, Bruno O, Bondavalli F, Mosti L, Maga G, Crespan E, Carraro F, Manetti F, Tintori C, Botta M.
    Eur J Med Chem; 2008 Dec 06; 43(12):2665-76. PubMed ID: 18342402
    [Abstract] [Full Text] [Related]

  • 20. Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases.
    McClellan WJ, Dai Y, Abad-Zapatero C, Albert DH, Bouska JJ, Glaser KB, Magoc TJ, Marcotte PA, Osterling DJ, Stewart KD, Davidsen SK, Michaelides MR.
    Bioorg Med Chem Lett; 2011 Sep 15; 21(18):5620-4. PubMed ID: 21778056
    [Abstract] [Full Text] [Related]

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