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Journal Abstract Search

196 related items for PubMed ID: 22940460

  • 1. Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes.
    Surendradoss J, Chang TK, Abbott FS.
    Toxicol Appl Pharmacol; 2012 Nov 01; 264(3):413-22. PubMed ID: 22940460
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  • 2. Role of oxidative metabolism in the effect of valproic acid on markers of cell viability, necrosis, and oxidative stress in sandwich-cultured rat hepatocytes.
    Kiang TK, Teng XW, Karagiozov S, Surendradoss J, Chang TK, Abbott FS.
    Toxicol Sci; 2010 Dec 01; 118(2):501-9. PubMed ID: 20861068
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  • 3. Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity.
    Kiang TK, Teng XW, Surendradoss J, Karagiozov S, Abbott FS, Chang TK.
    Toxicol Appl Pharmacol; 2011 May 01; 252(3):318-24. PubMed ID: 21397622
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  • 4. Evaluation of in situ generated valproyl 1-O-β-acyl glucuronide in valproic acid toxicity in sandwich-cultured rat hepatocytes.
    Surendradoss J, Chang TK, Abbott FS.
    Drug Metab Dispos; 2014 Nov 01; 42(11):1834-42. PubMed ID: 25147275
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  • 5. Cytotoxicity of unsaturated metabolites of valproic acid and protection by vitamins C and E in glutathione-depleted rat hepatocytes.
    Jurima-Romet M, Abbott FS, Tang W, Huang HS, Whitehouse LW.
    Toxicology; 1996 Aug 01; 112(1):69-85. PubMed ID: 8792850
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  • 8. Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates.
    Tang W, Abbott FS.
    Chem Res Toxicol; 1996 Mar 01; 9(2):517-26. PubMed ID: 8839057
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  • 10. Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats.
    Tong V, Teng XW, Chang TK, Abbott FS.
    Toxicol Sci; 2005 Aug 01; 86(2):427-35. PubMed ID: 15858223
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  • 11. Cytochrome P-450-mediated dehydrogenation of 2-n-propyl-2(E)-pentenoic acid, a pharmacologically-active metabolite of valproic acid, in rat liver microsomal preparations.
    Kassahun K, Baillie TA.
    Drug Metab Dispos; 1993 Aug 01; 21(2):242-8. PubMed ID: 8097692
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  • 12. P450-catalyzed in-chain desaturation of valproic acid: isoform selectivity and mechanism of formation of Delta 3-valproic acid generated by baculovirus-expressed CYP3A1.
    Fisher MB, Thompson SJ, Ribeiro V, Lechner MC, Rettie AE.
    Arch Biochem Biophys; 1998 Aug 01; 356(1):63-70. PubMed ID: 9681992
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  • 13. Valproic acid glucuronidation is associated with increases in 15-F2t-isoprostane in rats.
    Tong V, Teng XW, Karagiozov S, Chang TK, Abbott FS.
    Free Radic Biol Med; 2005 Jun 01; 38(11):1471-83. PubMed ID: 15890621
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  • 14. Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes.
    Tong V, Teng XW, Chang TK, Abbott FS.
    Toxicol Sci; 2005 Aug 01; 86(2):436-43. PubMed ID: 15858222
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  • 15. Identification and characterization of N-acetylcysteine conjugates of valproic acid in humans and animals.
    Gopaul SV, Farrell K, Abbott FS.
    Drug Metab Dispos; 2000 Jul 01; 28(7):823-32. PubMed ID: 10859157
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  • 17. Cytochrome P-450-catalyzed desaturation of valproic acid in vitro. Species differences, induction effects, and mechanistic studies.
    Rettie AE, Boberg M, Rettenmeier AW, Baillie TA.
    J Biol Chem; 1988 Sep 25; 263(27):13733-8. PubMed ID: 3138238
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  • 18. Characterization of thiol-conjugated metabolites of 2-propylpent-4-enoic acid (4-ene VPA), a toxic metabolite of valproic acid, by electrospray tandem mass spectrometry.
    Tang W, Abbott FS.
    J Mass Spectrom; 1996 Aug 25; 31(8):926-36. PubMed ID: 8799319
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  • 19. The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats.
    Tong V, Chang TK, Chen J, Abbott FS.
    Free Radic Biol Med; 2003 Jun 01; 34(11):1435-46. PubMed ID: 12757854
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