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262 related items for PubMed ID: 22942075

  • 1. Novel chimeras of botulinum and tetanus neurotoxins yield insights into their distinct sites of neuroparalysis.
    Wang J, Zurawski TH, Meng J, Lawrence GW, Aoki KR, Wheeler L, Dolly JO.
    FASEB J; 2012 Dec; 26(12):5035-48. PubMed ID: 22942075
    [Abstract] [Full Text] [Related]

  • 2. Targeted delivery into motor nerve terminals of inhibitors for SNARE-cleaving proteases via liposomes coupled to an atoxic botulinum neurotoxin.
    Edupuganti OP, Ovsepian SV, Wang J, Zurawski TH, Schmidt JJ, Smith L, Lawrence GW, Dolly JO.
    FEBS J; 2012 Jul; 279(14):2555-67. PubMed ID: 22607388
    [Abstract] [Full Text] [Related]

  • 3. Internalization and retrograde axonal trafficking of tetanus toxin in motor neurons and trans-synaptic propagation at central synapses exceed those of its C-terminal-binding fragments.
    Ovsepian SV, Bodeker M, O'Leary VB, Lawrence GW, Oliver Dolly J.
    Brain Struct Funct; 2015 Jul; 220(3):1825-38. PubMed ID: 25665801
    [Abstract] [Full Text] [Related]

  • 4. Botulinum neurotoxins A and E undergo retrograde axonal transport in primary motor neurons.
    Restani L, Giribaldi F, Manich M, Bercsenyi K, Menendez G, Rossetto O, Caleo M, Schiavo G.
    PLoS Pathog; 2012 Dec; 8(12):e1003087. PubMed ID: 23300443
    [Abstract] [Full Text] [Related]

  • 5. Longer-acting and highly potent chimaeric inhibitors of excessive exocytosis created with domains from botulinum neurotoxin A and B.
    Wang J, Zurawski TH, Bodeker MO, Meng J, Boddul S, Aoki KR, Dolly JO.
    Biochem J; 2012 May 15; 444(1):59-67. PubMed ID: 22360156
    [Abstract] [Full Text] [Related]

  • 6. Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons.
    Höltje M, Schulze S, Strotmeier J, Mahrhold S, Richter K, Binz T, Bigalke H, Ahnert-Hilger G, Rummel A.
    Toxicon; 2013 Dec 01; 75():108-21. PubMed ID: 23817019
    [Abstract] [Full Text] [Related]

  • 7. Novel therapeutics based on recombinant botulinum neurotoxins to normalize the release of transmitters and pain mediators.
    Dolly JO, Wang J, Zurawski TH, Meng J.
    FEBS J; 2011 Dec 01; 278(23):4454-66. PubMed ID: 21645262
    [Abstract] [Full Text] [Related]

  • 8. Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics.
    Wang J, Meng J, Lawrence GW, Zurawski TH, Sasse A, Bodeker MO, Gilmore MA, Fernández-Salas E, Francis J, Steward LE, Aoki KR, Dolly JO.
    J Biol Chem; 2008 Jun 20; 283(25):16993-7002. PubMed ID: 18400760
    [Abstract] [Full Text] [Related]

  • 9. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25.
    Blasi J, Chapman ER, Link E, Binz T, Yamasaki S, De Camilli P, Südhof TC, Niemann H, Jahn R.
    Nature; 1993 Sep 09; 365(6442):160-3. PubMed ID: 8103915
    [Abstract] [Full Text] [Related]

  • 10. A dileucine in the protease of botulinum toxin A underlies its long-lived neuroparalysis: transfer of longevity to a novel potential therapeutic.
    Wang J, Zurawski TH, Meng J, Lawrence G, Olango WM, Finn DP, Wheeler L, Dolly JO.
    J Biol Chem; 2011 Feb 25; 286(8):6375-85. PubMed ID: 21138836
    [Abstract] [Full Text] [Related]

  • 11. Is the light chain subcellular localization an important factor in botulinum toxin duration of action?
    Fernández-Salas E, Ho H, Garay P, Steward LE, Aoki KR.
    Mov Disord; 2004 Mar 25; 19 Suppl 8():S23-34. PubMed ID: 15027051
    [Abstract] [Full Text] [Related]

  • 12. Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.
    Pirazzini M, Henke T, Rossetto O, Mahrhold S, Krez N, Rummel A, Montecucco C, Binz T.
    FEBS Lett; 2013 Nov 29; 587(23):3831-6. PubMed ID: 24157364
    [Abstract] [Full Text] [Related]

  • 13. The travel diaries of tetanus and botulinum neurotoxins.
    Surana S, Tosolini AP, Meyer IFG, Fellows AD, Novoselov SS, Schiavo G.
    Toxicon; 2018 Jun 01; 147():58-67. PubMed ID: 29031941
    [Abstract] [Full Text] [Related]

  • 14. Translocation of botulinum neurotoxin light chain protease through the heavy chain channel.
    Koriazova LK, Montal M.
    Nat Struct Biol; 2003 Jan 01; 10(1):13-8. PubMed ID: 12459720
    [Abstract] [Full Text] [Related]

  • 15. Clostridial neurotoxins and substrate proteolysis in intact neurons: botulinum neurotoxin C acts on synaptosomal-associated protein of 25 kDa.
    Williamson LC, Halpern JL, Montecucco C, Brown JE, Neale EA.
    J Biol Chem; 1996 Mar 29; 271(13):7694-9. PubMed ID: 8631808
    [Abstract] [Full Text] [Related]

  • 16. Functional characterisation of tetanus and botulinum neurotoxins binding domains.
    Lalli G, Herreros J, Osborne SL, Montecucco C, Rossetto O, Schiavo G.
    J Cell Sci; 1999 Aug 29; 112 ( Pt 16)():2715-24. PubMed ID: 10413679
    [Abstract] [Full Text] [Related]

  • 17. Tetanus and botulinum neurotoxins: mechanism of action and therapeutic uses.
    Pellizzari R, Rossetto O, Schiavo G, Montecucco C.
    Philos Trans R Soc Lond B Biol Sci; 1999 Feb 28; 354(1381):259-68. PubMed ID: 10212474
    [Abstract] [Full Text] [Related]

  • 18. Fusion of Golgi-derived vesicles mediated by SNAP-25 is essential for sympathetic neuron outgrowth but relatively insensitive to botulinum neurotoxins in vitro.
    Lawrence GW, Wang J, Brin MF, Aoki KR, Wheeler L, Dolly JO.
    FEBS J; 2014 Jul 28; 281(14):3243-60. PubMed ID: 24863955
    [Abstract] [Full Text] [Related]

  • 19. Tetanus and botulinum neurotoxins: turning bad guys into good by research.
    Rossetto O, Seveso M, Caccin P, Schiavo G, Montecucco C.
    Toxicon; 2001 Jan 28; 39(1):27-41. PubMed ID: 10936621
    [Abstract] [Full Text] [Related]

  • 20. Inhibition of neurotransmitter release by botulinum neurotoxins and tetanus toxin at Aplysia synapses: role of the constituent chains.
    Poulain B, Mochida S, Wadsworth JD, Weller U, Habermann E, Dolly JO, Tauc L.
    J Physiol (Paris); 1990 Jan 28; 84(4):247-61. PubMed ID: 1981913
    [Abstract] [Full Text] [Related]

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