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Journal Abstract Search

117 related items for PubMed ID: 22959244

  • 1. Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT(4) receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation.
    Long DD, Armstrong SR, Beattie DT, Choi SK, Fatheree PR, Gendron RA, Genov D, Goldblum AA, Humphrey PP, Jiang L, Marquess DG, Shaw JP, Smith JA, Turner SD, Vickery RG.
    Bioorg Med Chem Lett; 2012 Oct 01; 22(19):6048-52. PubMed ID: 22959244
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  • 2. Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: clinical compound TD-2749.
    Long DD, Armstrong SR, Beattie DT, Choi SK, Fatheree PR, Gendron RA, Goldblum AA, Humphrey PP, Marquess DG, Shaw JP, Smith JA, Derek Turner S, Vickery RG.
    Bioorg Med Chem Lett; 2012 Jul 15; 22(14):4849-53. PubMed ID: 22683222
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  • 3. Clinical trial: the efficacy and tolerability of velusetrag, a selective 5-HT4 agonist with high intrinsic activity, in chronic idiopathic constipation - a 4-week, randomized, double-blind, placebo-controlled, dose-response study.
    Goldberg M, Li YP, Johanson JF, Mangel AW, Kitt M, Beattie DT, Kersey K, Daniels O.
    Aliment Pharmacol Ther; 2010 Nov 15; 32(9):1102-12. PubMed ID: 21039672
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  • 4. 5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment.
    Shen F, Smith JA, Chang R, Bourdet DL, Tsuruda PR, Obedencio GP, Beattie DT.
    Neuropharmacology; 2011 Nov 15; 61(1-2):69-79. PubMed ID: 21392515
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  • 6. Discovery of TD-8954, a clinical stage 5-HT(4) receptor agonist with gastrointestinal prokinetic properties.
    McKinnell RM, Armstrong SR, Beattie DT, Fatheree PR, Long DD, Marquess DG, Shaw JP, Vickery RG.
    Bioorg Med Chem Lett; 2013 Jul 15; 23(14):4210-5. PubMed ID: 23756062
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  • 7. A multivalent approach to the design and discovery of orally efficacious 5-HT4 receptor agonists.
    McKinnell RM, Armstrong SR, Beattie DT, Choi SK, Fatheree PR, Gendron RA, Goldblum A, Humphrey PP, Long DD, Marquess DG, Shaw JP, Smith JA, Turner SD, Vickery RG.
    J Med Chem; 2009 Sep 10; 52(17):5330-43. PubMed ID: 19663444
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  • 11. The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity.
    Smith JA, Beattie DT, Marquess D, Shaw JP, Vickery RG, Humphrey PP.
    Naunyn Schmiedebergs Arch Pharmacol; 2008 Jul 10; 378(1):125-37. PubMed ID: 18415081
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  • 12. Effects of Velusetrag (TD-5108) on gastrointestinal transit and bowel function in health and pharmacokinetics in health and constipation.
    Manini ML, Camilleri M, Goldberg M, Sweetser S, McKinzie S, Burton D, Wong S, Kitt MM, Li YP, Zinsmeister AR.
    Neurogastroenterol Motil; 2010 Jan 10; 22(1):42-9, e7-8. PubMed ID: 19691492
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  • 13. Luminal 5-HT4 receptors-A successful target for prokinetic actions.
    Gwynne RM, Bornstein JC.
    Neurogastroenterol Motil; 2019 Oct 10; 31(10):e13708. PubMed ID: 31524331
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  • 15. Synergistic effect between 5-HT4 receptor agonist and phosphodiesterase 4-inhibitor in releasing acetylcholine in pig gastric circular muscle in vitro.
    Lefebvre RA, Van Colen I, Pauwelyn V, De Maeyer JH.
    Eur J Pharmacol; 2016 Jun 15; 781():76-82. PubMed ID: 27060014
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  • 17. Synthesis and structure-activity relationship studies in serotonin 5-HT4 receptor ligands based on a benzo[de][2,6]naphthridine scaffold.
    Castriconi F, Paolino M, Giuliani G, Anzini M, Campiani G, Mennuni L, Sabatini C, Lanza M, Caselli G, De Rienzo F, Menziani MC, Sbraccia M, Molinari P, Costa T, Cappelli A.
    Eur J Med Chem; 2014 Jul 23; 82():36-46. PubMed ID: 24871995
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  • 20. The in vitro pharmacology and non-clinical cardiovascular safety studies of a novel 5-HT4 receptor agonist, DSP-6952.
    Tsubouchi T, Kunimatsu T, Tsujimoto S, Kiyoshi A, Katsura Y, Oku S, Chihara K, Mine Y, Yamada T, Shimizu I, Bando K.
    Eur J Pharmacol; 2018 May 05; 826():96-105. PubMed ID: 29501863
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