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166 related items for PubMed ID: 22960938

  • 1. The pterocarpanquinone LQB 118 induces apoptosis in tumor cells through the intrinsic pathway and the endoplasmic reticulum stress pathway.
    de Sá Bacelar T, da Silva AJ, Costa PR, Rumjanek VM.
    Anticancer Drugs; 2013 Jan; 24(1):73-83. PubMed ID: 22960938
    [Abstract] [Full Text] [Related]

  • 2. LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells.
    Maia RC, Vasconcelos FC, de Sá Bacelar T, Salustiano EJ, da Silva LF, Pereira DL, Moellman-Coelho A, Netto CD, da Silva AJ, Rumjanek VM, Costa PR.
    Invest New Drugs; 2011 Dec; 29(6):1143-55. PubMed ID: 20499132
    [Abstract] [Full Text] [Related]

  • 3. Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia cells.
    Cheong JW, Chong SY, Kim JY, Eom JI, Jeung HK, Maeng HY, Lee ST, Min YH.
    Clin Cancer Res; 2003 Oct 15; 9(13):5018-27. PubMed ID: 14581377
    [Abstract] [Full Text] [Related]

  • 4. The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression.
    Martino T, Magalhães FC, Justo GA, Coelho MG, Netto CD, Costa PR, Sabino KC.
    Bioorg Med Chem; 2014 Jun 15; 22(12):3115-22. PubMed ID: 24794748
    [Abstract] [Full Text] [Related]

  • 5. LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis.
    Ribeiro GA, Cunha-Júnior EF, Pinheiro RO, da-Silva SA, Canto-Cavalheiro MM, da Silva AJ, Costa PR, Netto CD, Melo RC, Almeida-Amaral EE, Torres-Santos EC.
    J Antimicrob Chemother; 2013 Apr 15; 68(4):789-99. PubMed ID: 23288404
    [Abstract] [Full Text] [Related]

  • 6. Sorbitol-induced apoptosis of human leukemia is mediated by caspase activation and cytochrome c release.
    Marfè G, Morgante E, Di Stefano C, Di Renzo L, De Martino L, Iovane G, Russo MA, Sinibaldi-Salimei P.
    Arch Toxicol; 2008 Jun 15; 82(6):371-7. PubMed ID: 18046541
    [Abstract] [Full Text] [Related]

  • 7. NFκB pathway and microRNA-9 and -21 are involved in sensitivity to the pterocarpanquinone LQB-118 in different CML cell lines.
    de Faria FC, Leal ME, Bernardo PS, Costa PR, Maia RC.
    Anticancer Agents Med Chem; 2015 Jun 15; 15(3):345-52. PubMed ID: 25964959
    [Abstract] [Full Text] [Related]

  • 8. N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells.
    Kim BM, Choi YJ, Han Y, Yun YS, Hong SH.
    Toxicol Appl Pharmacol; 2009 Aug 15; 239(1):87-97. PubMed ID: 19481559
    [Abstract] [Full Text] [Related]

  • 9. Insights into the Biological Evaluation of Pterocarpanquinones and Carbapterocarpans with Anti-tumor Activity against MDR Leukemias.
    Rumjanek VM, Maia RC, Salustiano EJ, Costa PRR.
    Anticancer Agents Med Chem; 2019 Aug 15; 19(1):29-37. PubMed ID: 29692266
    [Abstract] [Full Text] [Related]

  • 10. Bee venom induces apoptosis through intracellular Ca2+ -modulated intrinsic death pathway in human bladder cancer cells.
    Ip SW, Chu YL, Yu CS, Chen PY, Ho HC, Yang JS, Huang HY, Chueh FS, Lai TY, Chung JG.
    Int J Urol; 2012 Jan 15; 19(1):61-70. PubMed ID: 22151644
    [Abstract] [Full Text] [Related]

  • 11. A novel kind of nitrogen heterocycle compound induces apoptosis of human chronic myelogenous leukemia K562 cells.
    Ding G, Liu F, Yang T, Jiang Y, Fu H, Zhao Y.
    Bioorg Med Chem; 2006 Jun 01; 14(11):3766-74. PubMed ID: 16466924
    [Abstract] [Full Text] [Related]

  • 12. Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis.
    Liu MJ, Wang Z, Ju Y, Wong RN, Wu QY.
    Cancer Chemother Pharmacol; 2005 Jan 01; 55(1):79-90. PubMed ID: 15372201
    [Abstract] [Full Text] [Related]

  • 13. Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo.
    Chun-Guang W, Jun-Qing Y, Bei-Zhong L, Dan-Ting J, Chong W, Liang Z, Dan Z, Yan W.
    Eur J Pharmacol; 2010 Feb 10; 627(1-3):33-41. PubMed ID: 19857484
    [Abstract] [Full Text] [Related]

  • 14. Methyl angolensate, a natural tetranortriterpenoid induces intrinsic apoptotic pathway in leukemic cells.
    Chiruvella KK, Kari V, Choudhary B, Nambiar M, Ghanta RG, Raghavan SC.
    FEBS Lett; 2008 Dec 10; 582(29):4066-76. PubMed ID: 19022252
    [Abstract] [Full Text] [Related]

  • 15. Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation.
    Shi X, Jin Y, Cheng C, Zhang H, Zou W, Zheng Q, Lu Z, Chen Q, Lai Y, Pan J.
    Clin Cancer Res; 2009 Mar 01; 15(5):1686-97. PubMed ID: 19240172
    [Abstract] [Full Text] [Related]

  • 16. Pterocarpanquinone LQB-118 induces apoptosis in Leishmania (Viannia) braziliensis and controls lesions in infected hamsters.
    Costa L, Pinheiro RO, Dutra PM, Santos RF, Cunha-Júnior EF, Torres-Santos EC, da Silva AJ, Costa PR, Da-Silva SA.
    PLoS One; 2014 Mar 01; 9(10):e109672. PubMed ID: 25340550
    [Abstract] [Full Text] [Related]

  • 17. 2-Methoxyestradiol blocks cell-cycle progression at the G2/M phase and induces apoptosis in human acute T lymphoblastic leukemia CEM cells.
    Zhang X, Huang H, Xu Z, Zhan R.
    Acta Biochim Biophys Sin (Shanghai); 2010 Sep 01; 42(9):615-22. PubMed ID: 20732853
    [Abstract] [Full Text] [Related]

  • 18. The therapeutical potential of a novel pterocarpanquinone LQB-118 to target inhibitor of apoptosis proteins in acute myeloid leukemia cells.
    de Souza Reis FR, de Faria FC, Castro CP, de Souza PS, da Cunha Vasconcelos F, Bello RD, da Silva AJ, Costa PR, Maia RC.
    Anticancer Agents Med Chem; 2013 Feb 01; 13(2):341-51. PubMed ID: 22721384
    [Abstract] [Full Text] [Related]

  • 19. Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells.
    Yu C, Krystal G, Dent P, Grant S.
    Clin Cancer Res; 2002 Sep 01; 8(9):2976-84. PubMed ID: 12231544
    [Abstract] [Full Text] [Related]

  • 20. Glycyrrhizic acid induces apoptosis in WEHI-3 mouse leukemia cells through the caspase- and mitochondria-dependent pathways.
    Chueh FS, Hsiao YT, Chang SJ, Wu PP, Yang JS, Lin JJ, Chung JG, Lai TY.
    Oncol Rep; 2012 Dec 01; 28(6):2069-76. PubMed ID: 22972479
    [Abstract] [Full Text] [Related]

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