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Journal Abstract Search

94 related items for PubMed ID: 22962271

  • 1. Genetic screening for synthetic lethal partners of polynucleotide kinase/phosphatase: potential for targeting SHP-1-depleted cancers.
    Mereniuk TR, Maranchuk RA, Schindler A, Penner-Chea J, Freschauf GK, Hegazy S, Lai R, Foley E, Weinfeld M.
    Cancer Res; 2012 Nov 15; 72(22):5934-44. PubMed ID: 22962271
    [Abstract] [Full Text] [Related]

  • 2. Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase.
    Mereniuk TR, El Gendy MA, Mendes-Pereira AM, Lord CJ, Ghosh S, Foley E, Ashworth A, Weinfeld M.
    Mol Cancer Ther; 2013 Oct 15; 12(10):2135-44. PubMed ID: 23883586
    [Abstract] [Full Text] [Related]

  • 3. Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase.
    Freschauf GK, Karimi-Busheri F, Ulaczyk-Lesanko A, Mereniuk TR, Ahrens A, Koshy JM, Rasouli-Nia A, Pasarj P, Holmes CF, Rininsland F, Hall DG, Weinfeld M.
    Cancer Res; 2009 Oct 01; 69(19):7739-46. PubMed ID: 19773431
    [Abstract] [Full Text] [Related]

  • 4. Linker region is required for efficient nuclear localization of polynucleotide kinase phosphatase.
    Tsukada K, Matsumoto Y, Shimada M.
    PLoS One; 2020 Oct 01; 15(9):e0239404. PubMed ID: 32970693
    [Abstract] [Full Text] [Related]

  • 5. Persistent 3'-phosphate termini and increased cytotoxicity of radiomimetic DNA double-strand breaks in cells lacking polynucleotide kinase/phosphatase despite presence of an alternative 3'-phosphatase.
    Chalasani SL, Kawale AS, Akopiants K, Yu Y, Fanta M, Weinfeld M, Povirk LF.
    DNA Repair (Amst); 2018 Aug 01; 68():12-24. PubMed ID: 29807321
    [Abstract] [Full Text] [Related]

  • 6. Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.
    Freschauf GK, Mani RS, Mereniuk TR, Fanta M, Virgen CA, Dianov GL, Grassot JM, Hall DG, Weinfeld M.
    J Biol Chem; 2010 Jan 22; 285(4):2351-60. PubMed ID: 19940137
    [Abstract] [Full Text] [Related]

  • 7. The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair.
    Breslin C, Mani RS, Fanta M, Hoch N, Weinfeld M, Caldecott KW.
    J Biol Chem; 2017 Sep 29; 292(39):16024-16031. PubMed ID: 28821613
    [Abstract] [Full Text] [Related]

  • 8. Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome.
    Mandal SM, Hegde ML, Chatterjee A, Hegde PM, Szczesny B, Banerjee D, Boldogh I, Gao R, Falkenberg M, Gustafsson CM, Sarkar PS, Hazra TK.
    J Biol Chem; 2012 Jan 20; 287(4):2819-29. PubMed ID: 22130663
    [Abstract] [Full Text] [Related]

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  • 10. Nanoencapsulation of Novel Inhibitors of PNKP for Selective Sensitization to Ionizing Radiation and Irinotecan and Induction of Synthetic Lethality.
    Shire Z, Vakili MR, Morgan TDR, Hall DG, Lavasanifar A, Weinfeld M.
    Mol Pharm; 2018 Jun 04; 15(6):2316-2326. PubMed ID: 29688721
    [Abstract] [Full Text] [Related]

  • 11. Loss of the DNA repair protein, polynucleotide kinase/phosphatase, activates the type 1 interferon response independent of ionizing radiation.
    Kate WD, Fanta M, Weinfeld M.
    Nucleic Acids Res; 2024 Sep 09; 52(16):9630-9653. PubMed ID: 39087523
    [Abstract] [Full Text] [Related]

  • 12. The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy.
    Yang B, Zhang B, Cao Z, Xu X, Huo Z, Zhang P, Xiang S, Zhao Z, Lv C, Meng M, Zhang G, Dong L, Shi S, Yang L, Zhou Q.
    Cell Death Differ; 2020 Aug 09; 27(8):2433-2450. PubMed ID: 32144382
    [Abstract] [Full Text] [Related]

  • 13. Polynucleotide kinase-phosphatase (PNKP) mutations and neurologic disease.
    Dumitrache LC, McKinnon PJ.
    Mech Ageing Dev; 2017 Jan 09; 161(Pt A):121-129. PubMed ID: 27125728
    [Abstract] [Full Text] [Related]

  • 14. The FHA domain of PNKP is essential for its recruitment to DNA damage sites and maintenance of genome stability.
    Tsukada K, Shimada M, Imamura R, Saikawa K, Ishiai M, Matsumoto Y.
    Mutat Res; 2021 Jan 09; 822():111727. PubMed ID: 33220551
    [Abstract] [Full Text] [Related]

  • 15. Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair.
    Kalasova I, Hailstone R, Bublitz J, Bogantes J, Hofmann W, Leal A, Hanzlikova H, Caldecott KW.
    Nucleic Acids Res; 2020 Jul 09; 48(12):6672-6684. PubMed ID: 32504494
    [Abstract] [Full Text] [Related]

  • 16. Knockdown of protein tyrosine phosphatase SHP-1 inhibits G1/S progression in prostate cancer cells through the regulation of components of the cell-cycle machinery.
    Rodríguez-Ubreva FJ, Cariaga-Martinez AE, Cortés MA, Romero-De Pablos M, Ropero S, López-Ruiz P, Colás B.
    Oncogene; 2010 Jan 21; 29(3):345-55. PubMed ID: 19838216
    [Abstract] [Full Text] [Related]

  • 17. Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair.
    Reynolds JJ, Walker AK, Gilmore EC, Walsh CA, Caldecott KW.
    Nucleic Acids Res; 2012 Aug 21; 40(14):6608-19. PubMed ID: 22508754
    [Abstract] [Full Text] [Related]

  • 18. Novel PNKP mutations associated with reduced DNA single-strand break repair and severe microcephaly, seizures, and developmental delay.
    Thuresson AC, Brazina J, Akram T, Albrecht J, Dahl N, Soussi Zander C, Caldecott KW.
    Mol Genet Genomic Med; 2024 Jan 21; 12(1):e2295. PubMed ID: 37916443
    [Abstract] [Full Text] [Related]

  • 19. Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability.
    Shimada M, Dumitrache LC, Russell HR, McKinnon PJ.
    EMBO J; 2015 Oct 01; 34(19):2465-80. PubMed ID: 26290337
    [Abstract] [Full Text] [Related]

  • 20. Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.
    Weinfeld M, Mani RS, Abdou I, Aceytuno RD, Glover JN.
    Trends Biochem Sci; 2011 May 01; 36(5):262-71. PubMed ID: 21353781
    [Abstract] [Full Text] [Related]

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