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Journal Abstract Search

135 related items for PubMed ID: 22971011

  • 1. Design, synthesis, and structure-activity relationships of novel pyrazolo[5,1-b]thiazole derivatives as potent and orally active corticotropin-releasing factor 1 receptor antagonists.
    Takahashi Y, Hashizume M, Shin K, Terauchi T, Takeda K, Hibi S, Murata-Tai K, Fujisawa M, Shikata K, Taguchi R, Ino M, Shibata H, Yonaga M.
    J Med Chem; 2012 Oct 11; 55(19):8450-63. PubMed ID: 22971011
    [Abstract] [Full Text] [Related]

  • 2. Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists.
    Chen C, Wilcoxen KM, Huang CQ, Xie YF, McCarthy JR, Webb TR, Zhu YF, Saunders J, Liu XJ, Chen TK, Bozigian H, Grigoriadis DE.
    J Med Chem; 2004 Sep 09; 47(19):4787-98. PubMed ID: 15341493
    [Abstract] [Full Text] [Related]

  • 3. Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists.
    Gross RS, Guo Z, Dyck B, Coon T, Huang CQ, Lowe RF, Marinkovic D, Moorjani M, Nelson J, Zamani-Kord S, Grigoriadis DE, Hoare SR, Crowe PD, Bu JH, Haddach M, McCarthy J, Saunders J, Sullivan R, Chen T, Williams JP.
    J Med Chem; 2005 Sep 08; 48(18):5780-93. PubMed ID: 16134945
    [Abstract] [Full Text] [Related]

  • 4. Optimization of 3-phenylpyrazolo[1,5-a]pyrimidines as potent corticotropin-releasing factor-1 antagonists with adequate lipophilicity and water solubility.
    Chen C, Wilcoxen KM, Huang CQ, McCarthy JR, Chen T, Grigoriadis DE.
    Bioorg Med Chem Lett; 2004 Jul 16; 14(14):3669-73. PubMed ID: 15203140
    [Abstract] [Full Text] [Related]

  • 5. Potent, orally active corticotropin-releasing factor receptor-1 antagonists containing a tricyclic pyrrolopyridine or pyrazolopyridine core.
    Dyck B, Grigoriadis DE, Gross RS, Guo Z, Haddach M, Marinkovic D, McCarthy JR, Moorjani M, Regan CF, Saunders J, Schwaebe MK, Szabo T, Williams JP, Zhang X, Bozigian H, Chen TK.
    J Med Chem; 2005 Jun 16; 48(12):4100-10. PubMed ID: 15943483
    [Abstract] [Full Text] [Related]

  • 6. Rational design, synthesis, and structure-activity relationships of aryltriazoles as novel corticotropin-releasing factor-1 receptor antagonists.
    Lowe RF, Nelson J, Dang TN, Crowe PD, Pahuja A, McCarthy JR, Grigoriadis DE, Conlon P, Saunders J, Chen C, Szabo T, Chen TK, Bozigian H.
    J Med Chem; 2005 Mar 10; 48(5):1540-9. PubMed ID: 15743196
    [Abstract] [Full Text] [Related]

  • 7. 8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.
    Gilligan PJ, He L, Clarke T, Tivitmahaisoon P, Lelas S, Li YW, Heman K, Fitzgerald L, Miller K, Zhang G, Marshall A, Krause C, McElroy J, Ward K, Shen H, Wong H, Grossman S, Nemeth G, Zaczek R, Arneric SP, Hartig P, Robertson DW, Trainor G.
    J Med Chem; 2009 May 14; 52(9):3073-83. PubMed ID: 19361210
    [Abstract] [Full Text] [Related]

  • 8. Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor.
    Takahashi Y, Hibi S, Hoshino Y, Kikuchi K, Shin K, Murata-Tai K, Fujisawa M, Ino M, Shibata H, Yonaga M.
    J Med Chem; 2012 Jun 14; 55(11):5255-69. PubMed ID: 22587443
    [Abstract] [Full Text] [Related]

  • 9. Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists.
    Guo Z, Tellew JE, Gross RS, Dyck B, Grey J, Haddach M, Kiankarimi M, Lanier M, Li BF, Luo Z, McCarthy JR, Moorjani M, Saunders J, Sullivan R, Zhang X, Zamani-Kord S, Grigoriadis DE, Crowe PD, Chen TK, Williams JP.
    J Med Chem; 2005 Aug 11; 48(16):5104-7. PubMed ID: 16078829
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and SAR of 2-aryloxy-4-alkoxy-pyridines as potent orally active corticotropin-releasing factor 1 receptor antagonists.
    Chen YL, Braselton J, Forman J, Gallaschun RJ, Mansbach R, Schmidt AW, Seeger TF, Sprouse JS, Tingley FD, Winston E, Schulz DW.
    J Med Chem; 2008 Mar 13; 51(5):1377-84. PubMed ID: 18260619
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists.
    Gilligan PJ, Clarke T, He L, Lelas S, Li YW, Heman K, Fitzgerald L, Miller K, Zhang G, Marshall A, Krause C, McElroy JF, Ward K, Zeller K, Wong H, Bai S, Saye J, Grossman S, Zaczek R, Arneric SP, Hartig P, Robertson D, Trainor G.
    J Med Chem; 2009 May 14; 52(9):3084-92. PubMed ID: 19361209
    [Abstract] [Full Text] [Related]

  • 12. Design, synthesis, and biological evaluation of 1,2,3,7-tetrahydro-6h-purin-6-one and 3,7-dihydro-1h-purine-2,6-dione derivatives as corticotropin-releasing factor(1) receptor antagonists.
    Hartz RA, Nanda KK, Ingalls CL, Ahuja VT, Molski TF, Zhang G, Wong H, Peng Y, Kelley M, Lodge NJ, Zaczek R, Gilligan PJ, Trainor GL.
    J Med Chem; 2004 Sep 09; 47(19):4741-54. PubMed ID: 15341489
    [Abstract] [Full Text] [Related]

  • 13. 6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists.
    Saito T, Obitsu T, Kondo T, Matsui T, Nagao Y, Kusumi K, Matsumura N, Ueno S, Kishi A, Katsumata S, Kagamiishi Y, Nakai H, Toda M.
    Bioorg Med Chem; 2011 Sep 15; 19(18):5432-45. PubMed ID: 21865047
    [Abstract] [Full Text] [Related]

  • 14. Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.
    Hodgetts KJ, Ge P, Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Kieltyka A, Horvath RF, Kehne JH, Krause JE, Maynard GD, Hoffman D, Lee Y, Fung L, Doller D.
    J Med Chem; 2011 Jun 23; 54(12):4187-206. PubMed ID: 21618986
    [Abstract] [Full Text] [Related]

  • 15. The CRF(1) receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats.
    McElroy JF, Ward KA, Zeller KL, Jones KW, Gilligan PJ, He L, Lelas S.
    Psychopharmacology (Berl); 2002 Dec 23; 165(1):86-92. PubMed ID: 12474122
    [Abstract] [Full Text] [Related]

  • 16. Synthesis, structure-activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists.
    Han X, Michne JA, Pin SS, Burris KD, Balanda LA, Fung LK, Fiedler T, Browman KE, Taber MT, Zhang J, Dubowchik GM.
    Bioorg Med Chem Lett; 2005 Sep 01; 15(17):3870-3. PubMed ID: 15990298
    [Abstract] [Full Text] [Related]

  • 17. Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists.
    Huang CQ, Wilcoxen KM, Grigoriadis DE, McCarthy JR, Chen C.
    Bioorg Med Chem Lett; 2004 Aug 02; 14(15):3943-7. PubMed ID: 15225703
    [Abstract] [Full Text] [Related]

  • 18. Selective corticotropin-releasing factor 1 receptor antagonist E2508 has potent antidepressant-like and anxiolytic-like properties in rodent models.
    Taguchi R, Shikata K, Furuya Y, Ino M, Shin K, Shibata H.
    Behav Brain Res; 2016 Oct 01; 312():138-47. PubMed ID: 27297028
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold.
    Cappelli A, Bini G, Valenti S, Giuliani G, Paolino M, Anzini M, Vomero S, Giorgi G, Giordani A, Stasi LP, Makovec F, Ghelardini C, Di Cesare Mannelli L, Concas A, Porcu P, Biggio G.
    J Med Chem; 2011 Oct 27; 54(20):7165-75. PubMed ID: 21916402
    [Abstract] [Full Text] [Related]

  • 20. Pyrrolo[1,2-b]pyridazines, pyrrolo[2,1-f]triazin-4(3H)-ones, and related compounds as novel corticotropin-releasing factor 1 (CRF₁) receptor antagonists.
    Saito T, Obitsu T, Kohno H, Sugimoto I, Matsushita T, Nishiyama T, Hirota T, Takeda H, Matsumura N, Ueno S, Kishi A, Kagamiishi Y, Nakai H, Takaoka Y.
    Bioorg Med Chem; 2012 Jan 15; 20(2):1122-38. PubMed ID: 22196514
    [Abstract] [Full Text] [Related]

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